The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia.
The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors for Volume 1 - p. xix 7. Preface for Volume 1 - p. xxv 8. Copyright - p. xxvi 9. Contributors for Volume 2 - p. xxvi 10. Preface for Volume 2 - p. xxvii 11. Copyright - p. xxviii 12. Contributors for Volume 3 - p. xv 13. Preface for Volume 3 - p. xviii 14. Part I - p. xviii 15. Part I: Setting the scene: General aspects of anesthesia, analgesics and pain - p. xviii 16. Chapter 1. The concept of multimorphic cancer pain: A new approach from diagnosis to treatment - p. 3 17. Chapter 2. Recent advances in the linkage of attachment and pain: A new review - p. 15 18. Chapter 3. The management of pain in older people - p. 27 19. Chapter 4. Anesthesia and body mass: Epidural depth and beyond - p. 37 20. Chapter 5. Anesthetics and analgesic activities of herbal medicine: Review of the possible mechanism of action - p. 47 21. Chapter 6. Analgesia-first sedation and nonopioid multimodal analgesia in the intensive care unit - p. 60 22. Chapter 7. The multidisciplinary Acute Pain Service: Features and experiences - p. 69 23. Chapter 8. Monitoring anesthesia: Electroencephalography and beyond - p. 79 24. Part II: The syndromes of pain - p. 89 25. Chapter 9. Cluster headache and pain: Features and treatments - p. 96 26. Chapter 10. Migraine and pain: Features and treatments - p. 105 27. Chapter 11. Complex regional pain syndrome - p. 117 28. Chapter 12. Phantom limb pain - p. 125 29. Chapter 13. Painful diabetic neuropathy: The roles of microglia - p. 139 30. Chapter 14. Maternal deprivation and nociception - p. 154 31. Chapter 15. Giving birth and pain - p. 163 32. Chapter 16. Abdominal pain in gastroparesis - p. 173 33. Chapter 17. Appendicitis and related abdominal pain - p. 189 34. Chapter 18. Ovarian hormones, site-specific nociception, and hypertension - p. 201 35. Chapter 19. Linking the heart and pain: Physiological and psychophysiological mechanisms - p. 211 36. Chapter 20. Chronic pain in military veterans - p. 225 37. Chapter 21. Nociception during surgery - p. 235 38. Chapter 22. Breast cancer and nociceptione - p. 247 39. Chapter 23. Postoperative pain after rhinoplasty and rhinologic surgery - p. 257 40. Chapter 24. Pain response, neonates, and venipuncture - p. 265 41. Chapter 25. Carpal tunnel syndrome and pain - p. 275 42. Chapter 26. Pain and HIV - p. 285 43. Chapter 27. Pain mechanisms in computer and smartphone users - p. 291 44. Part III: Interlinking anesthesia, analgesics and pain - p. 301 45. Chapter 28. Health professionals’ and lay people’s positions regarding the use of analgesics in cancer cases - p. 305 46. Chapter 29. Manual compression at myofascial trigger points ameliorates musculoskeletal pain - p. 321 47. Chapter 30. Multimodal analgesia and postsurgical pain - p. 329 48. Chapter 31. Pain, ultrasound-guided Pecs II block, and general anesthesia - p. 343 49. Chapter 32. Pain control during prostate biopsy and evolution of local anesthesia techniques - p. 353 50. Chapter 33. Pain reduction in cosmetic injections: Fillers and beyond - p. 363 51. Chapter 34. Anesthesia and combat-related extremity injury - p. 373 52. Chapter 35. Spinal anesthesia: Applications to cesarean section and pain - p. 381 53. Chapter 36. Postoperative pain management: Truncal blocks in thoracic surgery - p. 391 54. Chapter 37. Postoperative pain management: Truncal blocks in general surgery - p. 405 55. Chapter 38. Linking analgesia, epidural oxycodone, pain, and laparoscopy - p. 421 56. Chapter 39. Levobupivacaine features and linking in infiltrating analgesia - p. 433 57. Part IV: Assessments, screening, and resources - p. 442 58. Chapter 40. The pain catastrophizing scale: Features and applications - p. 445 59. Chapter 41. Pain-related behavioral scales among a low back pain population: A narrative review - p. 451 60. Chapter 42. The analgesia nociception index: Features and application - p. 463 61. Chapter 43. Pain, anesthetics and analgesics/back pain evaluation questionnaires - p. 475 62. Chapter 44. The back pain functional scale: Features and applications - p. 487 63. Chapter 45. Cognitive impairment, pain, and analgesia - p. 503 64. Chapter 46. Biomarkers in endometriosis-associated pain - p. 512 65. Chapter 47. Biomarkers in bladder pain syndrome: A new narrative - p. 529 66. Chapter 48. Biomarkers of statin-induced musculoskeletal pain: Vitamin D and beyond - p. 539 67. Chapter 49. Performance-based and self-reported physical fitness in musculoskeletal pain - p. 553 68. Part I - p. 561 69. Part I: Drugs and agents used in anesthesia and analgesia - p. 561 70. Chapter 1. Anesthesia for malignant hyperthermia susceptible patients - p. 561 71. Chapter 2. Use of dextran in regional anesthesia - p. 14 72. Chapter 3. Intraperitoneal local anesthetic agents in the management of postoperative pain - p. 26 73. Chapter 4. Automatic control of anesthesia via different vital signs - p. 26 74. Chapter 5. Non-opioid based analgesia in otolaryngology - p. 36 75. Part II: Mechanisms of action of drugs - p. 46 76. Chapter 6. Buprenorphine: Mechanism and applications - p. 46 77. Chapter 7. Caffeine as analgesic adjuvant - p. 57 78. Chapter 8. Chloroprocaine: Features and applications - p. 56 79. Chapter 9. Clonidine: Features and applications - p. 56 80. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: σ1 receptor - p. 56 81. Chapter 11. Isoflurane: Mechanisms and applications - p. 93 82. Chapter 12. The lidocaine patch: Features and applications: Post-thoracotomy pain and beyond - p. 93 83. Chapter 13. Memantine: Features and application in the management of chronic pain - p. 110 84. Chapter 14. Midazolam: Mechanism and perioperative applications - p. 127 85. Chapter 15. Intravenous paracetamol: Features and applications - p. 127 86. Chapter 16. Prilocaine: Mechanisms and application - p. 149 87. Chapter 17. Sevoflurane: Features and uses in topical application for wound care - p. 162 88. Chapter 18. Tramadol as an analgesic - p. 176 89. Part III: Adverse effects, reactions, and outcomes - p. 176 90. Chapter 19. Long-term effects of anesthesia on the brain: an update on neurotoxicity - p. 176 91. Chapter 20. Breastfeeding and mother-baby dyad’s competence following neuraxial labor analgesia - p. 200 92. Chapter 21. Mechanistic overview of how opioid analgesics promote constipation - p. 224 93. Chapter 22. Cognitive behavioral therapy for chronic pain and opioid use disorder - p. 224 94. Chapter 23. Preoperative opioid and benzodiazepines: Impact on adverse outcomes - p. 246 95. Chapter 24. Malignant hyperthermia syndrome and hydrogen sulfide signaling: Role of Kv7 channels - p. 256 96. Chapter 25. Problems with epidural catheter - p. 226 97. Chapter 26. Headache after neuraxial blocks: A focus on combined spinal-epidural anesthesia - p. 274 98. Chapter 27. Liposomal bupivacaine, pain relief and adverse events - p. 302 99. Chapter 28. Adverse events associated with analgesics: A focus on paracetamol use - p. 304 100. Part IV: Novel and nonpharmacological aspects and treatments - p. 317 101. Acronychia pedunculata leaves and usage in pain - p. 317 102. Adansonia digitata and its use in neuropathic pain: Prostaglandins and beyond - p. 317 103. Andrographis paniculata standardized extract (ParActin) and pain - p. 342 104. Chapter 32. Capsaicin: Features usage in diabetic neuropathic pain - p. 362 105. Cola nitida and pain relief - p. 366 106. Chapter 34. Analgesic effects of Ephedra herb and ephedrine alkaloids-free Ephedra herb extract (EFE) - p. 380 107. Euphorbia bicolor (Euphorbiaceae) latex phytochemicals and applications to analgesia - p. 390 108. Analgesic properties and mechanisms of action of Muntingia calabura extracts: A review - p. 404 109. Chapter 37. Resolving neuroinflammation and pain with maresin 1, a specialized pro-resolving lipid mediator - p. 420 110. Chapter 38. Therapeutic role of naringenin to alleviate inflammatory pain - p. 443 111. Analgesic properties of plants from the genus Solanum L. (Solanaceae) - p. 444 112. Chapter 40. Dietary constituents act as local anesthetic agents: Neurophysiological mechanism of nociceptive pain - p. 462 113. Chapter 41. Pain response following prenatal stress and its modulation by antioxidants - p. 474 114. Chapter 42. Physical activity and exercise in the prevention of musculoskeletal pain in children and adolescents - p. 493 115. Chapter 43. Linking aerobic exercise and childhood pain alleviation: A narrative - p. 507 116. Chapter 44. Physical activity and exercise in the management of chronic widespread musculoskeletal pain: A focus on fibromyalgia - p. 515 117. Chapter 45. Spinal cord stimulation and limb pain - p. 527 118. Chapter 46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders - p. 551 119. Chapter 47. Virtual reality and applications to treating neck pain - p. 565 120. Chapter 48. Virtual reality induced analgesia and dental pain - p. 575 121. Chapter 49. Vibrotactile devices, DentalVibe, and local anesthesia - p. 583 122. Chapter 50. Cooled radiofrequency ablation as a treatment for knee osteoarthritis - p. 589 123. Chapter 51. Nonpharmacologic analgesic therapies: A focus on photobiomodulation, acustimulation, and cryoanalgesia (ice) therapy - p. 603 124. Chapter 52. New coping strategies and self-education for chronic pain management: E-health - p. 617 125. Chapter 53. Postoperative pain management: Truncal blocks in obstetric and gynecologic surgery - p. 629 126. Part I - p. 641 127. Part I: Molecular and cellular aspects - p. 641 128. Chapter 1. KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain - p. 641 129. A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis - p. i6 130. Chapter 3. Prdm12, a key transcriptional regulator of the nociceptive lineage - p. i6 131. Chapter 4. Genetics of chronic widespread musculoskeletal pain - p. i6 132. Chapter 5. Fentanyl: Polymorphisms, and adverse events - p. i6 133. Chapter 6. Propofol anesthesia and molecular changes in the brain - p. i6 134. Chapter 7. Protein kinase G is a molecular switch for pain - p. i6 135. Chapter 8. Adrenergic agonists and antagonists enhance opioid receptor activity - p. i6 136. Chapter 9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic system - p. i6 137. Clinacanthus nutans L., analgesia, and the L-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway - p. i6 138. The orally bioavailable imidazodiazepine, KRM-II-81, is a novel potentiator of α2/3-containing GABAA receptors with analgesic efficacy - p. i6 139. Extrasynaptic α5GABAA receptors and their role in nociception and pathological pain - p. i6 140. Chapter 13. ATP-sensitive potassium channels in pain and analgesia - p. i6 141. Chapter 14. Astrocyte-neuron lactate shuttle and pain - p. i6 142. Chapter 15. Nociception and sweet solutions: Applications to inflammatory pain - p. i6 143. Chapter 16. Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain - p. i6 144. Chapter 17. Neurons of the parabrachial nucleus, nociceptive input, and pain pathways - p. i6 145. Chapter 18. Anterior cingulate cortex, pain perception, and pathological neuronal plasticity during chronic pain - p. i6 146. Chapter 19. Sleep deprivation, headache, and Fos immunohistochemistry - p. i6 147. Chapter 20. Antinociceptive glucagon-like peptides - p. 206 148. Chapter 21. Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs) - p. 206 149. Chapter 22. TRPM8 receptor and menthol in pain management - p. 206 150. Part II: Physiology, imaging and physical recordings - p. 206 151. Chapter 23. Anesthetic and proconvulsant effects of ketamine on EEG - p. 206 152. Chapter 24. Electroencephalography and anesthetic doses of ketamine - p. 258 153. Chapter 25. Linking heart function and analgesia - p. 258 154. Chapter 26. Computed tomography-guided procedures for epidural injections - p. 277 155. Chapter 27. Chronic pain: Linking deep brain stimulation and sensory functional MRI - p. 277 156. Chapter 28. Neurocognition and placebo analgesia: Linking in functional magnetic resonance imaging - p. 277 157. Chapter 29. Linking the cortex, functional spectroscopy, and pain: Features and applications - p. 277 158. Chapter 30. Muscle origins of myofascial pain syndrome - p. 277 159. Part III: Psychology and behavior - p. 277 160. Chapter 31. Behavioral markers of pain: Understanding the cognitive, motor, and societal interactions in the pain experience - p. 277 161. Chapter 32. Adverse life events, sensitization of spinal nociception, and chronic pain risk - p. 277 162. Cognitive-affective modulation of pain: The placebo and nocebo phenomena and their impact on pain treatment - p. 277 163. Chapter 34. Nociception-related behavioral phenotypes in adult zebrafish - p. 277 164. Chapter 35. Pain, implantable pain devices, and psychosocial aspects of pain - p. 277 165. Chapter 36. Influence of psychological factors on myofascial pain - p. 277 166. Part IV: Resources - p. 411 167. Chapter 37. Recommended resources, sites, and research groups for the neuroscience of anesthetics and analgesics - p. 411 168. Index - p. 411 169. Index - p. 643 170. Index - p. 652
The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia.
The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors for Volume 1 - p. xix 7. Preface for Volume 1 - p. xxv 8. Copyright - p. xxvi 9. Contributors for Volume 2 - p. xxvi 10. Preface for Volume 2 - p. xxvii 11. Copyright - p. xxviii 12. Contributors for Volume 3 - p. xv 13. Preface for Volume 3 - p. xviii 14. Part I - p. xviii 15. Part I: Setting the scene: General aspects of anesthesia, analgesics and pain - p. xviii 16. Chapter 1. The concept of multimorphic cancer pain: A new approach from diagnosis to treatment - p. 3 17. Chapter 2. Recent advances in the linkage of attachment and pain: A new review - p. 15 18. Chapter 3. The management of pain in older people - p. 27 19. Chapter 4. Anesthesia and body mass: Epidural depth and beyond - p. 37 20. Chapter 5. Anesthetics and analgesic activities of herbal medicine: Review of the possible mechanism of action - p. 47 21. Chapter 6. Analgesia-first sedation and nonopioid multimodal analgesia in the intensive care unit - p. 60 22. Chapter 7. The multidisciplinary Acute Pain Service: Features and experiences - p. 69 23. Chapter 8. Monitoring anesthesia: Electroencephalography and beyond - p. 79 24. Part II: The syndromes of pain - p. 89 25. Chapter 9. Cluster headache and pain: Features and treatments - p. 96 26. Chapter 10. Migraine and pain: Features and treatments - p. 105 27. Chapter 11. Complex regional pain syndrome - p. 117 28. Chapter 12. Phantom limb pain - p. 125 29. Chapter 13. Painful diabetic neuropathy: The roles of microglia - p. 139 30. Chapter 14. Maternal deprivation and nociception - p. 154 31. Chapter 15. Giving birth and pain - p. 163 32. Chapter 16. Abdominal pain in gastroparesis - p. 173 33. Chapter 17. Appendicitis and related abdominal pain - p. 189 34. Chapter 18. Ovarian hormones, site-specific nociception, and hypertension - p. 201 35. Chapter 19. Linking the heart and pain: Physiological and psychophysiological mechanisms - p. 211 36. Chapter 20. Chronic pain in military veterans - p. 225 37. Chapter 21. Nociception during surgery - p. 235 38. Chapter 22. Breast cancer and nociceptione - p. 247 39. Chapter 23. Postoperative pain after rhinoplasty and rhinologic surgery - p. 257 40. Chapter 24. Pain response, neonates, and venipuncture - p. 265 41. Chapter 25. Carpal tunnel syndrome and pain - p. 275 42. Chapter 26. Pain and HIV - p. 285 43. Chapter 27. Pain mechanisms in computer and smartphone users - p. 291 44. Part III: Interlinking anesthesia, analgesics and pain - p. 301 45. Chapter 28. Health professionals’ and lay people’s positions regarding the use of analgesics in cancer cases - p. 305 46. Chapter 29. Manual compression at myofascial trigger points ameliorates musculoskeletal pain - p. 321 47. Chapter 30. Multimodal analgesia and postsurgical pain - p. 329 48. Chapter 31. Pain, ultrasound-guided Pecs II block, and general anesthesia - p. 343 49. Chapter 32. Pain control during prostate biopsy and evolution of local anesthesia techniques - p. 353 50. Chapter 33. Pain reduction in cosmetic injections: Fillers and beyond - p. 363 51. Chapter 34. Anesthesia and combat-related extremity injury - p. 373 52. Chapter 35. Spinal anesthesia: Applications to cesarean section and pain - p. 381 53. Chapter 36. Postoperative pain management: Truncal blocks in thoracic surgery - p. 391 54. Chapter 37. Postoperative pain management: Truncal blocks in general surgery - p. 405 55. Chapter 38. Linking analgesia, epidural oxycodone, pain, and laparoscopy - p. 421 56. Chapter 39. Levobupivacaine features and linking in infiltrating analgesia - p. 433 57. Part IV: Assessments, screening, and resources - p. 442 58. Chapter 40. The pain catastrophizing scale: Features and applications - p. 445 59. Chapter 41. Pain-related behavioral scales among a low back pain population: A narrative review - p. 451 60. Chapter 42. The analgesia nociception index: Features and application - p. 463 61. Chapter 43. Pain, anesthetics and analgesics/back pain evaluation questionnaires - p. 475 62. Chapter 44. The back pain functional scale: Features and applications - p. 487 63. Chapter 45. Cognitive impairment, pain, and analgesia - p. 503 64. Chapter 46. Biomarkers in endometriosis-associated pain - p. 512 65. Chapter 47. Biomarkers in bladder pain syndrome: A new narrative - p. 529 66. Chapter 48. Biomarkers of statin-induced musculoskeletal pain: Vitamin D and beyond - p. 539 67. Chapter 49. Performance-based and self-reported physical fitness in musculoskeletal pain - p. 553 68. Part I - p. 561 69. Part I: Drugs and agents used in anesthesia and analgesia - p. 561 70. Chapter 1. Anesthesia for malignant hyperthermia susceptible patients - p. 561 71. Chapter 2. Use of dextran in regional anesthesia - p. 14 72. Chapter 3. Intraperitoneal local anesthetic agents in the management of postoperative pain - p. 26 73. Chapter 4. Automatic control of anesthesia via different vital signs - p. 26 74. Chapter 5. Non-opioid based analgesia in otolaryngology - p. 36 75. Part II: Mechanisms of action of drugs - p. 46 76. Chapter 6. Buprenorphine: Mechanism and applications - p. 46 77. Chapter 7. Caffeine as analgesic adjuvant - p. 57 78. Chapter 8. Chloroprocaine: Features and applications - p. 56 79. Chapter 9. Clonidine: Features and applications - p. 56 80. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: σ1 receptor - p. 56 81. Chapter 11. Isoflurane: Mechanisms and applications - p. 93 82. Chapter 12. The lidocaine patch: Features and applications: Post-thoracotomy pain and beyond - p. 93 83. Chapter 13. Memantine: Features and application in the management of chronic pain - p. 110 84. Chapter 14. Midazolam: Mechanism and perioperative applications - p. 127 85. Chapter 15. Intravenous paracetamol: Features and applications - p. 127 86. Chapter 16. Prilocaine: Mechanisms and application - p. 149 87. Chapter 17. Sevoflurane: Features and uses in topical application for wound care - p. 162 88. Chapter 18. Tramadol as an analgesic - p. 176 89. Part III: Adverse effects, reactions, and outcomes - p. 176 90. Chapter 19. Long-term effects of anesthesia on the brain: an update on neurotoxicity - p. 176 91. Chapter 20. Breastfeeding and mother-baby dyad’s competence following neuraxial labor analgesia - p. 200 92. Chapter 21. Mechanistic overview of how opioid analgesics promote constipation - p. 224 93. Chapter 22. Cognitive behavioral therapy for chronic pain and opioid use disorder - p. 224 94. Chapter 23. Preoperative opioid and benzodiazepines: Impact on adverse outcomes - p. 246 95. Chapter 24. Malignant hyperthermia syndrome and hydrogen sulfide signaling: Role of Kv7 channels - p. 256 96. Chapter 25. Problems with epidural catheter - p. 226 97. Chapter 26. Headache after neuraxial blocks: A focus on combined spinal-epidural anesthesia - p. 274 98. Chapter 27. Liposomal bupivacaine, pain relief and adverse events - p. 302 99. Chapter 28. Adverse events associated with analgesics: A focus on paracetamol use - p. 304 100. Part IV: Novel and nonpharmacological aspects and treatments - p. 317 101. Acronychia pedunculata leaves and usage in pain - p. 317 102. Adansonia digitata and its use in neuropathic pain: Prostaglandins and beyond - p. 317 103. Andrographis paniculata standardized extract (ParActin) and pain - p. 342 104. Chapter 32. Capsaicin: Features usage in diabetic neuropathic pain - p. 362 105. Cola nitida and pain relief - p. 366 106. Chapter 34. Analgesic effects of Ephedra herb and ephedrine alkaloids-free Ephedra herb extract (EFE) - p. 380 107. Euphorbia bicolor (Euphorbiaceae) latex phytochemicals and applications to analgesia - p. 390 108. Analgesic properties and mechanisms of action of Muntingia calabura extracts: A review - p. 404 109. Chapter 37. Resolving neuroinflammation and pain with maresin 1, a specialized pro-resolving lipid mediator - p. 420 110. Chapter 38. Therapeutic role of naringenin to alleviate inflammatory pain - p. 443 111. Analgesic properties of plants from the genus Solanum L. (Solanaceae) - p. 444 112. Chapter 40. Dietary constituents act as local anesthetic agents: Neurophysiological mechanism of nociceptive pain - p. 462 113. Chapter 41. Pain response following prenatal stress and its modulation by antioxidants - p. 474 114. Chapter 42. Physical activity and exercise in the prevention of musculoskeletal pain in children and adolescents - p. 493 115. Chapter 43. Linking aerobic exercise and childhood pain alleviation: A narrative - p. 507 116. Chapter 44. Physical activity and exercise in the management of chronic widespread musculoskeletal pain: A focus on fibromyalgia - p. 515 117. Chapter 45. Spinal cord stimulation and limb pain - p. 527 118. Chapter 46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders - p. 551 119. Chapter 47. Virtual reality and applications to treating neck pain - p. 565 120. Chapter 48. Virtual reality induced analgesia and dental pain - p. 575 121. Chapter 49. Vibrotactile devices, DentalVibe, and local anesthesia - p. 583 122. Chapter 50. Cooled radiofrequency ablation as a treatment for knee osteoarthritis - p. 589 123. Chapter 51. Nonpharmacologic analgesic therapies: A focus on photobiomodulation, acustimulation, and cryoanalgesia (ice) therapy - p. 603 124. Chapter 52. New coping strategies and self-education for chronic pain management: E-health - p. 617 125. Chapter 53. Postoperative pain management: Truncal blocks in obstetric and gynecologic surgery - p. 629 126. Part I - p. 641 127. Part I: Molecular and cellular aspects - p. 641 128. Chapter 1. KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain - p. 641 129. A new mutation in NTRK1 gene is associated with congenital insensitivity to pain without anhidrosis - p. i6 130. Chapter 3. Prdm12, a key transcriptional regulator of the nociceptive lineage - p. i6 131. Chapter 4. Genetics of chronic widespread musculoskeletal pain - p. i6 132. Chapter 5. Fentanyl: Polymorphisms, and adverse events - p. i6 133. Chapter 6. Propofol anesthesia and molecular changes in the brain - p. i6 134. Chapter 7. Protein kinase G is a molecular switch for pain - p. i6 135. Chapter 8. Adrenergic agonists and antagonists enhance opioid receptor activity - p. i6 136. Chapter 9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic system - p. i6 137. Clinacanthus nutans L., analgesia, and the L-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway - p. i6 138. The orally bioavailable imidazodiazepine, KRM-II-81, is a novel potentiator of α2/3-containing GABAA receptors with analgesic efficacy - p. i6 139. Extrasynaptic α5GABAA receptors and their role in nociception and pathological pain - p. i6 140. Chapter 13. ATP-sensitive potassium channels in pain and analgesia - p. i6 141. Chapter 14. Astrocyte-neuron lactate shuttle and pain - p. i6 142. Chapter 15. Nociception and sweet solutions: Applications to inflammatory pain - p. i6 143. Chapter 16. Interlinking interleukin-33 (IL-33), neuroinflammation and neuropathic pain - p. i6 144. Chapter 17. Neurons of the parabrachial nucleus, nociceptive input, and pain pathways - p. i6 145. Chapter 18. Anterior cingulate cortex, pain perception, and pathological neuronal plasticity during chronic pain - p. i6 146. Chapter 19. Sleep deprivation, headache, and Fos immunohistochemistry - p. i6 147. Chapter 20. Antinociceptive glucagon-like peptides - p. 206 148. Chapter 21. Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs) - p. 206 149. Chapter 22. TRPM8 receptor and menthol in pain management - p. 206 150. Part II: Physiology, imaging and physical recordings - p. 206 151. Chapter 23. Anesthetic and proconvulsant effects of ketamine on EEG - p. 206 152. Chapter 24. Electroencephalography and anesthetic doses of ketamine - p. 258 153. Chapter 25. Linking heart function and analgesia - p. 258 154. Chapter 26. Computed tomography-guided procedures for epidural injections - p. 277 155. Chapter 27. Chronic pain: Linking deep brain stimulation and sensory functional MRI - p. 277 156. Chapter 28. Neurocognition and placebo analgesia: Linking in functional magnetic resonance imaging - p. 277 157. Chapter 29. Linking the cortex, functional spectroscopy, and pain: Features and applications - p. 277 158. Chapter 30. Muscle origins of myofascial pain syndrome - p. 277 159. Part III: Psychology and behavior - p. 277 160. Chapter 31. Behavioral markers of pain: Understanding the cognitive, motor, and societal interactions in the pain experience - p. 277 161. Chapter 32. Adverse life events, sensitization of spinal nociception, and chronic pain risk - p. 277 162. Cognitive-affective modulation of pain: The placebo and nocebo phenomena and their impact on pain treatment - p. 277 163. Chapter 34. Nociception-related behavioral phenotypes in adult zebrafish - p. 277 164. Chapter 35. Pain, implantable pain devices, and psychosocial aspects of pain - p. 277 165. Chapter 36. Influence of psychological factors on myofascial pain - p. 277 166. Part IV: Resources - p. 411 167. Chapter 37. Recommended resources, sites, and research groups for the neuroscience of anesthetics and analgesics - p. 411 168. Index - p. 411 169. Index - p. 643 170. Index - p. 652
