The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology.
Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.
1. The Regulatory Genome in Adaptation, Evolution, Development, and Disease - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page v 7. Preface - p. Page vi 8. Acknowledgments - p. Page vii 9. Epigraph - p. Page viii 10. List of Illustrations - p. Page ix 11. List of Tables - p. Page x 12. Chapter 1 : Gene regulation in physiological processes - p. Page x 13. Chapter 2 : Epigenetics, the nonprotein coding genome, and human accelerated sequences - p. Page 21 14. Chapter 3 : Gene expression and regulation relative to specific tissues and functions - p. Page 36 15. Chapter 4 : Evo-Devo and morphological diversity - p. Page 62 16. Chapter 5 : Adaptation and evolution - p. Page 83 17. Chapter 6 : Adaptations metabolic and genomic to environmental changes - p. Page 134 18. Chapter 7 : Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders - p. Page 158 19. Chapter 8 : Altered gene expression associated with developmental defects and disease - p. Page 180 20. Chapter 9 : Metabolic, epigenetic functions and correlations with phenotype - p. Page 216 21. Chapter 10 : Aging, genomic mitochondrial, and regulatory changes - p. Page 239 22. Chapter 11 : The regulatory genome and defects in monogenic diseases - p. Page 268 23. Chapter 12 : Epigenetics and human disease - p. Page 298 24. Chapter 13 : Connecting developmental defects and evolutionary findings - p. Page 324 25. Chapter 14 : The regulatory genome and complex common diseases - p. Page 354 26. Index - p. Page 385
The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology.
Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.
1. The Regulatory Genome in Adaptation, Evolution, Development, and Disease - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page v 7. Preface - p. Page vi 8. Acknowledgments - p. Page vii 9. Epigraph - p. Page viii 10. List of Illustrations - p. Page ix 11. List of Tables - p. Page x 12. Chapter 1 : Gene regulation in physiological processes - p. Page x 13. Chapter 2 : Epigenetics, the nonprotein coding genome, and human accelerated sequences - p. Page 21 14. Chapter 3 : Gene expression and regulation relative to specific tissues and functions - p. Page 36 15. Chapter 4 : Evo-Devo and morphological diversity - p. Page 62 16. Chapter 5 : Adaptation and evolution - p. Page 83 17. Chapter 6 : Adaptations metabolic and genomic to environmental changes - p. Page 134 18. Chapter 7 : Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders - p. Page 158 19. Chapter 8 : Altered gene expression associated with developmental defects and disease - p. Page 180 20. Chapter 9 : Metabolic, epigenetic functions and correlations with phenotype - p. Page 216 21. Chapter 10 : Aging, genomic mitochondrial, and regulatory changes - p. Page 239 22. Chapter 11 : The regulatory genome and defects in monogenic diseases - p. Page 268 23. Chapter 12 : Epigenetics and human disease - p. Page 298 24. Chapter 13 : Connecting developmental defects and evolutionary findings - p. Page 324 25. Chapter 14 : The regulatory genome and complex common diseases - p. Page 354 26. Index - p. Page 385
