The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox and provides a framework for future research with evidence-based and forward-looking content. Content makes use of modeling systems and current experiences derived from case studies to provide material that is cross-disciplinary, bridging interdisciplinary divides. Furthermore, consideration is given to the behavioral response to monkeypox infection, including barriers to vaccination. Each chapter contains structured content, including policy and procedures, applications to new or emerging communicable diseases, a mini dictionary of terms, and summary points.
Chapter contributions are from leading national and international specialists, including those from world renowned institutions who provide a global perspective. The book is a perfect reference for specialists in infectious diseases, virologists, microbiologists, health scientists, public health workers, doctors, pharmacologists, and research scientists.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xix 7. Preface - p. xxvii 8. Section 1: Setting the scene and introductory chapters - p. 1 9. Chapter 1. A brief synopsis of mpox - p. 3 10. Chapter 2. Monkeypox unveiled: understanding its impact on public health - p. 21 11. Chapter 3. Human monkeypox virus and its evolution - p. 45 12. Chapter 4. Importance of emerging lineages of monkeypox virus: an updated narrative - p. 59 13. Chapter 5. Bridging borders: the collective fight against monkeypox outbreaks - p. 75 14. Chapter 6. Social media and the response to mpox - p. 101 15. Section 2: The biology and transmission of mpox (monkeypox) - p. 115 16. Chapter 7. Mpox (monkeypox) virus: fundamental features of its particle, replication cycle, cytopathic effects and research models - p. 117 17. Chapter 8. Biology of the mpox virus and the cysteine protease structures and basis of in silico studies - p. 135 18. Chapter 9. The serial interval distribution of the mpox virus infection - p. 149 19. Chapter 10. Investigating mpox (monkeypox): linking web tools and genomic analysis - p. 167 20. Chapter 11. Mathematical modeling of mpox: a review - p. 187 21. Section 3: Detection and confirmation - p. 209 22. Chapter 12. Development, validation, and use of monkeypox virus assays within the clinical diagnostic and emergency use authorization/food and drug administration contexts - p. 211 23. Chapter 13. Primers and probes for the diagnostics of mpox virus - p. 227 24. Chapter 14. Mpox and wastewater surveillance: tracing the spread of a viral outbreak through environmental monitoring - p. 245 25. Section 4: Effects on the body tissues and organ systems - p. 267 26. Chapter 15. Time-related change in mpox (monkeypox) skin lesions and their progression - p. 269 27. Chapter 16. Atypical skin manifestations of MPOX - p. 291 28. Chapter 17. Variations in clinical features and symptoms in mpox (monkeypox) infection: fever and beyond - p. 307 29. Chapter 18. Otolaryngological features of mpox: lymphadenopathy, pharyngeal, and airways - p. 323 30. Chapter 19. Cardiac involvement of monkeypox - p. 337 31. Section 5: Vaccinations, treatments and alleviation of symptomology - p. 347 32. Chapter 20. The psychological responses of monkeypox (mpox) virus vaccination among health care workers: international aspects - p. 349 33. Chapter 21. Immunoinformatics and monkeypox virus vaccines - p. 365 34. Chapter 22. Barriers to mass vaccination against mpox (monkeypox): an overview - p. 379 35. Chapter 23. Approved and experimental antivirals for mpox - p. 401 36. Chapter 24. Repurposing drugs for monkeypox using artificial intelligence - p. 421 37. Chapter 25. mpox (monkeypox) clinical management—a review - p. 441 38. Chapter 26. Treating pustular skin lesions in viral infection: monkeypox and beyond - p. 459 39. Chapter 27. Treating concomitant human immunodeficiency virus and monkeypox virus infection - p. 473 40. Section 6: Case studies - p. 493 41. Chapter 28. Monkeypox and a typical scenario of a clinical presentation, diagnosis and successful treatment - p. 495 42. Chapter 29. Case study: heterosexual transmission of monkeypox - p. 505 43. Chapter 30. Case report: simultaneous presentation of human monkeypox virus and sexually transmitted diseases: a diagnostic and management challenge - p. 517 44. Chapter 31. Case study: anatomopathological findings in different monkeypox cutaneous lesions - p. 523 45. Chapter 32. Scaring and quality of life in MPOX - p. 533 46. Section 7: Resources - p. 541 47. Chapter 33. Recommended resources for the scientific basis of monkeypox - p. 543 48. Index - p. 553
The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox and provides a framework for future research with evidence-based and forward-looking content. Content makes use of modeling systems and current experiences derived from case studies to provide material that is cross-disciplinary, bridging interdisciplinary divides. Furthermore, consideration is given to the behavioral response to monkeypox infection, including barriers to vaccination. Each chapter contains structured content, including policy and procedures, applications to new or emerging communicable diseases, a mini dictionary of terms, and summary points.
Chapter contributions are from leading national and international specialists, including those from world renowned institutions who provide a global perspective. The book is a perfect reference for specialists in infectious diseases, virologists, microbiologists, health scientists, public health workers, doctors, pharmacologists, and research scientists.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xix 7. Preface - p. xxvii 8. Section 1: Setting the scene and introductory chapters - p. 1 9. Chapter 1. A brief synopsis of mpox - p. 3 10. Chapter 2. Monkeypox unveiled: understanding its impact on public health - p. 21 11. Chapter 3. Human monkeypox virus and its evolution - p. 45 12. Chapter 4. Importance of emerging lineages of monkeypox virus: an updated narrative - p. 59 13. Chapter 5. Bridging borders: the collective fight against monkeypox outbreaks - p. 75 14. Chapter 6. Social media and the response to mpox - p. 101 15. Section 2: The biology and transmission of mpox (monkeypox) - p. 115 16. Chapter 7. Mpox (monkeypox) virus: fundamental features of its particle, replication cycle, cytopathic effects and research models - p. 117 17. Chapter 8. Biology of the mpox virus and the cysteine protease structures and basis of in silico studies - p. 135 18. Chapter 9. The serial interval distribution of the mpox virus infection - p. 149 19. Chapter 10. Investigating mpox (monkeypox): linking web tools and genomic analysis - p. 167 20. Chapter 11. Mathematical modeling of mpox: a review - p. 187 21. Section 3: Detection and confirmation - p. 209 22. Chapter 12. Development, validation, and use of monkeypox virus assays within the clinical diagnostic and emergency use authorization/food and drug administration contexts - p. 211 23. Chapter 13. Primers and probes for the diagnostics of mpox virus - p. 227 24. Chapter 14. Mpox and wastewater surveillance: tracing the spread of a viral outbreak through environmental monitoring - p. 245 25. Section 4: Effects on the body tissues and organ systems - p. 267 26. Chapter 15. Time-related change in mpox (monkeypox) skin lesions and their progression - p. 269 27. Chapter 16. Atypical skin manifestations of MPOX - p. 291 28. Chapter 17. Variations in clinical features and symptoms in mpox (monkeypox) infection: fever and beyond - p. 307 29. Chapter 18. Otolaryngological features of mpox: lymphadenopathy, pharyngeal, and airways - p. 323 30. Chapter 19. Cardiac involvement of monkeypox - p. 337 31. Section 5: Vaccinations, treatments and alleviation of symptomology - p. 347 32. Chapter 20. The psychological responses of monkeypox (mpox) virus vaccination among health care workers: international aspects - p. 349 33. Chapter 21. Immunoinformatics and monkeypox virus vaccines - p. 365 34. Chapter 22. Barriers to mass vaccination against mpox (monkeypox): an overview - p. 379 35. Chapter 23. Approved and experimental antivirals for mpox - p. 401 36. Chapter 24. Repurposing drugs for monkeypox using artificial intelligence - p. 421 37. Chapter 25. mpox (monkeypox) clinical management—a review - p. 441 38. Chapter 26. Treating pustular skin lesions in viral infection: monkeypox and beyond - p. 459 39. Chapter 27. Treating concomitant human immunodeficiency virus and monkeypox virus infection - p. 473 40. Section 6: Case studies - p. 493 41. Chapter 28. Monkeypox and a typical scenario of a clinical presentation, diagnosis and successful treatment - p. 495 42. Chapter 29. Case study: heterosexual transmission of monkeypox - p. 505 43. Chapter 30. Case report: simultaneous presentation of human monkeypox virus and sexually transmitted diseases: a diagnostic and management challenge - p. 517 44. Chapter 31. Case study: anatomopathological findings in different monkeypox cutaneous lesions - p. 523 45. Chapter 32. Scaring and quality of life in MPOX - p. 533 46. Section 7: Resources - p. 541 47. Chapter 33. Recommended resources for the scientific basis of monkeypox - p. 543 48. Index - p. 553
