Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A “one size fits all approach is not sufficient to meet individual patients’ needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area.
Covers pathophysiology, early detection, biomarkers and diagnosis, therapies, controversies, future research, the use of AI, professional organizations and public health in sepsis.
Includes chapters on sepsis in special populations such as in pregnant women, transplanted patients, and children.
Consolidates today's available information on this timely topic into a single, convenient resource.
1. Part I: Introduction - p. xii 2. Chapter 1. Sepsis: Past, Present, and Future—Lessons Learned from COVID-19 - p. 1 3. Chapter 2. Sepsis Definitions: A Historical Perspective - p. 7 4. Chapter 3. The Epidemiology of Sepsis - p. 11 5. Part II: Basic Concepts - p. 15 6. Chapter 4. Pathophysiology of Sepsis - p. 17 7. Chapter 5. Sepsis and Microcirculation - p. 29 8. Chapter 6. Genetics and Sepsis - p. 35 9. Part III: Diagnosis and Monitoring - p. 39 10. Chapter 7. Screening and early detection of sepsis - p. 41 11. Chapter 8. Diagnosis and Monitoring of Sepsis - p. 55 12. Chapter 9. Sepsis: Molecular Diagnostics and Biomarkers - p. 65 13. Chapter 10. Hemodynamic Monitoring: Current Practice and New Perspectives - p. 75 14. Chapter 11. Point of Care Ultrasound in the Management of Sepsis - p. 89 15. Chapter 12. New Approaches and Understanding of Sepsis - p. 99 16. Chapter 13. Sepsis Quality Indicators in the Emergency Department - p. 105 17. Part IV: Treatment - p. 107 18. Chapter 14. Sepsis Treatment: Fluids - p. 109 19. Chapter 15. Vasopressor Therapy in Septic Shock - p. 121 20. Chapter 16. Mechanical Ventilation in Sepsis - p. 135 21. Chapter 17. Extracorporeal Membrane Oxygenation for the Support of Patients with Refractory Septic Shock - p. 139 22. Chapter 18. Antimicrobials in the Management of Sepsis - p. 149 23. Chapter 19. Kidney Support in Sepsis - p. 169 24. Chapter 20. Hematological Support in Sepsis - p. 177 25. Chapter 21. Specific Treatment of Focus Control in Sepsis - p. 183 26. Chapter 22. Sepsis Adjunctive Therapies - p. 205 27. Chapter 23. Glycemic Control and Stress Ulcer Prophylaxis - p. 211 28. Chapter 24. Nutrition in Sepsis - p. 221 29. Part V: Special Settings - p. 226 30. Chapter 25. Fever in Intensive Care Units - p. 229 31. Chapter 26. Sepsis—In the Era of Antimicrobial Resistance - p. 237 32. Chapter 27. Factors Underlying Racial and Gender Disparities in Sepsis Management - p. 247 33. Chapter 28. Sepsis in Special Populations - p. 257 34. Chapter 29. Comprehensive Management of Sepsis in Pediatrics - p. 271 35. Chapter 30. Maternal Sepsis - p. 283 36. Part VI: Special Considerations - p. 286 37. Chapter 31. Role of Preventive Measures in Sepsis - p. 287 38. Chapter 32. Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification - p. 297 39. Chapter 33. Long-Term Sequelae of Sepsis - p. 301 40. Part VII: Future Outlook - p. 312 41. Chapter 34. New Diagnostic and Therapeutic Perspectives - p. 313 42. Chapter 35. Artificial Intelligence in Sepsis - p. 323 43. Index - p. 333
Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A “one size fits all approach is not sufficient to meet individual patients’ needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area.
Covers pathophysiology, early detection, biomarkers and diagnosis, therapies, controversies, future research, the use of AI, professional organizations and public health in sepsis.
Includes chapters on sepsis in special populations such as in pregnant women, transplanted patients, and children.
Consolidates today's available information on this timely topic into a single, convenient resource.
1. Part I: Introduction - p. xii 2. Chapter 1. Sepsis: Past, Present, and Future—Lessons Learned from COVID-19 - p. 1 3. Chapter 2. Sepsis Definitions: A Historical Perspective - p. 7 4. Chapter 3. The Epidemiology of Sepsis - p. 11 5. Part II: Basic Concepts - p. 15 6. Chapter 4. Pathophysiology of Sepsis - p. 17 7. Chapter 5. Sepsis and Microcirculation - p. 29 8. Chapter 6. Genetics and Sepsis - p. 35 9. Part III: Diagnosis and Monitoring - p. 39 10. Chapter 7. Screening and early detection of sepsis - p. 41 11. Chapter 8. Diagnosis and Monitoring of Sepsis - p. 55 12. Chapter 9. Sepsis: Molecular Diagnostics and Biomarkers - p. 65 13. Chapter 10. Hemodynamic Monitoring: Current Practice and New Perspectives - p. 75 14. Chapter 11. Point of Care Ultrasound in the Management of Sepsis - p. 89 15. Chapter 12. New Approaches and Understanding of Sepsis - p. 99 16. Chapter 13. Sepsis Quality Indicators in the Emergency Department - p. 105 17. Part IV: Treatment - p. 107 18. Chapter 14. Sepsis Treatment: Fluids - p. 109 19. Chapter 15. Vasopressor Therapy in Septic Shock - p. 121 20. Chapter 16. Mechanical Ventilation in Sepsis - p. 135 21. Chapter 17. Extracorporeal Membrane Oxygenation for the Support of Patients with Refractory Septic Shock - p. 139 22. Chapter 18. Antimicrobials in the Management of Sepsis - p. 149 23. Chapter 19. Kidney Support in Sepsis - p. 169 24. Chapter 20. Hematological Support in Sepsis - p. 177 25. Chapter 21. Specific Treatment of Focus Control in Sepsis - p. 183 26. Chapter 22. Sepsis Adjunctive Therapies - p. 205 27. Chapter 23. Glycemic Control and Stress Ulcer Prophylaxis - p. 211 28. Chapter 24. Nutrition in Sepsis - p. 221 29. Part V: Special Settings - p. 226 30. Chapter 25. Fever in Intensive Care Units - p. 229 31. Chapter 26. Sepsis—In the Era of Antimicrobial Resistance - p. 237 32. Chapter 27. Factors Underlying Racial and Gender Disparities in Sepsis Management - p. 247 33. Chapter 28. Sepsis in Special Populations - p. 257 34. Chapter 29. Comprehensive Management of Sepsis in Pediatrics - p. 271 35. Chapter 30. Maternal Sepsis - p. 283 36. Part VI: Special Considerations - p. 286 37. Chapter 31. Role of Preventive Measures in Sepsis - p. 287 38. Chapter 32. Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification - p. 297 39. Chapter 33. Long-Term Sequelae of Sepsis - p. 301 40. Part VII: Future Outlook - p. 312 41. Chapter 34. New Diagnostic and Therapeutic Perspectives - p. 313 42. Chapter 35. Artificial Intelligence in Sepsis - p. 323 43. Index - p. 333
