The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations.
Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities.
The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis.
1. Chapter Two. Introduction to Basic Mechanics - p. 17 2. Chapter Three. Force Measurement and Mechanical Imaging Apparatuses - p. 35 3. Chapter Four. Interaction Forces - p. 63 4. Chapter Five. Polymer Chain Mechanics - p. 77 5. Chapter Six. Analysis of Data Gleaned by Atomic-Force Microscopy - p. 95 6. Chapter Seven. Single–Molecular Interaction - p. 111 7. Chapter Eight. Single-Molecule DNA and RNA Mechanics - p. 133 8. Chapter Nine. Single-Molecule Protein Mechanics - p. 147 9. Chapter Ten. Nanomechanics of Motion-Supporting Molecular Systems - p. 187 10. Chapter Eleven. Finite-Element Analysis of Microbiological Structures - p. 199 11. Chapter Twelve. Nanomechanical Bases of Cell Structure - p. 219 12. Chapter Thirteen. Nanorheology of Living Cells - p. 249 13. Chapter Fourteen. Molecular and Cellular Manipulations for Future Nanomedicine - p. 267 14. Appendix One. Beam Bending - p. 283 15. Appendix Two. V-Shaped Cantilever - p. 297 16. Appendix Three. Persistence Length Versus Kuhn Length - p. 299 17. Appendix Four. Hertz Model - p. 301 18. Appendix Five. Derivation of the Loading-Rate Dependence of the Mean Rupture Force - p. 309 19. Index - p. 313
The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations.
Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities.
The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis.
1. Chapter Two. Introduction to Basic Mechanics - p. 17 2. Chapter Three. Force Measurement and Mechanical Imaging Apparatuses - p. 35 3. Chapter Four. Interaction Forces - p. 63 4. Chapter Five. Polymer Chain Mechanics - p. 77 5. Chapter Six. Analysis of Data Gleaned by Atomic-Force Microscopy - p. 95 6. Chapter Seven. Single–Molecular Interaction - p. 111 7. Chapter Eight. Single-Molecule DNA and RNA Mechanics - p. 133 8. Chapter Nine. Single-Molecule Protein Mechanics - p. 147 9. Chapter Ten. Nanomechanics of Motion-Supporting Molecular Systems - p. 187 10. Chapter Eleven. Finite-Element Analysis of Microbiological Structures - p. 199 11. Chapter Twelve. Nanomechanical Bases of Cell Structure - p. 219 12. Chapter Thirteen. Nanorheology of Living Cells - p. 249 13. Chapter Fourteen. Molecular and Cellular Manipulations for Future Nanomedicine - p. 267 14. Appendix One. Beam Bending - p. 283 15. Appendix Two. V-Shaped Cantilever - p. 297 16. Appendix Three. Persistence Length Versus Kuhn Length - p. 299 17. Appendix Four. Hertz Model - p. 301 18. Appendix Five. Derivation of the Loading-Rate Dependence of the Mean Rupture Force - p. 309 19. Index - p. 313
