Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.
Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Cover Image Insert - p. iv 6. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. vii 7. About the Series Editor - p. ix 8. Aims and Scope of Volume - p. xi 9. About the Volume Editor - p. xiii 10. Preface - p. xv 11. Contributors - p. xxi 12. Chapter 1 Prostate gland anatomy and hormonal factors contributing to cancer development - p. 1 13. Chapter 2 Role of tumor microenvironment in prostate cancer therapy resistance - p. 27 14. Chapter 3 Androgen receptor-dependent mechanisms mediating therapy resistance in prostate cancer - p. 57 15. Chapter 4 Epigenetic changes driving therapy resistance in prostate cancer - p. 85 16. Chapter 5 Role of cancer stem cells in prostate cancer therapy resistance - p. 107 17. Chapter 6 Resistance to taxane chemotherapies in prostate cancer - p. 137 18. Chapter 7 Resistance of prostate cancer to topoisomerase inhibitors - p. 157 19. Chapter 8 Resistance of prostate cancer to kinase inhibitors - p. 179 20. Chapter 9 Radioresistance mechanisms in prostate cancer - p. 213 21. Chapter 10 Immunotherapeutic strategies and immunotherapy resistance in prostate cancer - p. 235 22. Chapter 11 Overcoming resistance in prostate cancer with targeted and small molecule-based therapies - p. 255 23. Chapter 12 Novel treatment strategies to overcome resistance in prostate cancer - p. 289 24. Index - p. 309
Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.
Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Cover Image Insert - p. iv 6. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. vii 7. About the Series Editor - p. ix 8. Aims and Scope of Volume - p. xi 9. About the Volume Editor - p. xiii 10. Preface - p. xv 11. Contributors - p. xxi 12. Chapter 1 Prostate gland anatomy and hormonal factors contributing to cancer development - p. 1 13. Chapter 2 Role of tumor microenvironment in prostate cancer therapy resistance - p. 27 14. Chapter 3 Androgen receptor-dependent mechanisms mediating therapy resistance in prostate cancer - p. 57 15. Chapter 4 Epigenetic changes driving therapy resistance in prostate cancer - p. 85 16. Chapter 5 Role of cancer stem cells in prostate cancer therapy resistance - p. 107 17. Chapter 6 Resistance to taxane chemotherapies in prostate cancer - p. 137 18. Chapter 7 Resistance of prostate cancer to topoisomerase inhibitors - p. 157 19. Chapter 8 Resistance of prostate cancer to kinase inhibitors - p. 179 20. Chapter 9 Radioresistance mechanisms in prostate cancer - p. 213 21. Chapter 10 Immunotherapeutic strategies and immunotherapy resistance in prostate cancer - p. 235 22. Chapter 11 Overcoming resistance in prostate cancer with targeted and small molecule-based therapies - p. 255 23. Chapter 12 Novel treatment strategies to overcome resistance in prostate cancer - p. 289 24. Index - p. 309
