Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.
It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.
1. Transcription and Translation in Health and Disease - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. About the editors - p. Page viii 8. Preface - p. Page ix 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Current perspective of transcriptional regulators in human health and diseases - p. Page xi 12. Chapter 2 : Role of alternative splicing in health and diseases - p. Page 13 13. Chapter 3 : Role of transcriptional and posttranscriptional regulation of sphingolipid genes in molecular heterogeneity of breast cancer - p. Page 31 14. Chapter 4 : Who dictates and when: Genetic and epigenetic dictatorships in breast cancer response and resistance to therapy - p. Page 44 15. Chapter 5 : Cross-talk between NF-κB and telomerase in cancer: Implications in therapy - p. Page 64 16. Chapter 6 : Genome editing and regulation of transcription and translational using CRISPR-Cas9 system - p. Page 79 17. Chapter 7 : Regulation of posttranscriptional events by RNA-binding proteins - p. Page 91 18. Chapter 8 : The language of posttranslational modifications and deciphering it from proteomics data - p. Page 103 19. Chapter 9 : Noncoding RNAs in human health and diseases - p. Page 127 20. Chapter 10 : MiRNAs as epigenetic regulators for gut microbiome - p. Page 151 21. Chapter 11 : Crosstalk between microRNAs and epigenetics during brain development and neurological diseases - p. Page 165 22. Chapter 12 : Implications of miRNA in autoimmune and inflammatory skin diseases - p. Page 194 23. Chapter 13 : Micro-RNA contribution to angiogenesis in cancer - p. Page 226 24. Chapter 14 : Emerging role of mRNA and RNA binding proteins in Diabetes - p. Page 240 25. Chapter 15 : Caenorhabditis elegans: An interesting host for aging-related studies - p. Page 251 26. Chapter 16 : The role of LncRNA and micro-RNA targeting GLI transcription factors in human cancers - p. Page 270 27. Chapter 17 : Inhibitors targeting epigenetic modifications in cancer - p. Page 282 28. Chapter 18 : Modulation of epigenetic methylation enzymes by synthetic and natural agents - p. Page 308 29. Chapter 19 : Transcriptional regulatory network associated with multiple sclerosis pathogenesis - p. Page 342 30. Chapter 20 : Role of adipokines in the pathophysiology of coronary artery disease - p. Page 365 31. Index - p. Page 381
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.
It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.
1. Transcription and Translation in Health and Disease - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. About the editors - p. Page viii 8. Preface - p. Page ix 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Current perspective of transcriptional regulators in human health and diseases - p. Page xi 12. Chapter 2 : Role of alternative splicing in health and diseases - p. Page 13 13. Chapter 3 : Role of transcriptional and posttranscriptional regulation of sphingolipid genes in molecular heterogeneity of breast cancer - p. Page 31 14. Chapter 4 : Who dictates and when: Genetic and epigenetic dictatorships in breast cancer response and resistance to therapy - p. Page 44 15. Chapter 5 : Cross-talk between NF-κB and telomerase in cancer: Implications in therapy - p. Page 64 16. Chapter 6 : Genome editing and regulation of transcription and translational using CRISPR-Cas9 system - p. Page 79 17. Chapter 7 : Regulation of posttranscriptional events by RNA-binding proteins - p. Page 91 18. Chapter 8 : The language of posttranslational modifications and deciphering it from proteomics data - p. Page 103 19. Chapter 9 : Noncoding RNAs in human health and diseases - p. Page 127 20. Chapter 10 : MiRNAs as epigenetic regulators for gut microbiome - p. Page 151 21. Chapter 11 : Crosstalk between microRNAs and epigenetics during brain development and neurological diseases - p. Page 165 22. Chapter 12 : Implications of miRNA in autoimmune and inflammatory skin diseases - p. Page 194 23. Chapter 13 : Micro-RNA contribution to angiogenesis in cancer - p. Page 226 24. Chapter 14 : Emerging role of mRNA and RNA binding proteins in Diabetes - p. Page 240 25. Chapter 15 : Caenorhabditis elegans: An interesting host for aging-related studies - p. Page 251 26. Chapter 16 : The role of LncRNA and micro-RNA targeting GLI transcription factors in human cancers - p. Page 270 27. Chapter 17 : Inhibitors targeting epigenetic modifications in cancer - p. Page 282 28. Chapter 18 : Modulation of epigenetic methylation enzymes by synthetic and natural agents - p. Page 308 29. Chapter 19 : Transcriptional regulatory network associated with multiple sclerosis pathogenesis - p. Page 342 30. Chapter 20 : Role of adipokines in the pathophysiology of coronary artery disease - p. Page 365 31. Index - p. Page 381
