Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included.
Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Dedication - p. ii 5. Copyright - p. iv 6. List of Contributors - p. xiii 7. Translational Advances in Gynecologic Cancers - p. xv 8. Part I: Ovarian Cancer - p. xvi 9. Chapter 1. Origins of Epithelial Ovarian Cancer - p. 3 10. Chapter 2. Ovarian Cancer Genomics - p. 19 11. Chapter 3. Epigenetics - p. 35 12. Chapter 4. Timing of Cytoreductive Surgery in the Treatment of Advanced Epithelial Ovarian Carcinoma - p. 59 13. Chapter 5. Angiogenesis - p. 79 14. Chapter 6. Homologous Recombination and BRCA Genes in Ovarian Cancer: Clinical Perspective of Novel Therapeutics - p. 111 15. Chapter 7. Molecular Basis of PARP Inhibition and Future Opportunities in Ovarian Cancer Therapy - p. 129 16. Chapter 8. Ovarian Cancer: New Targets and Future Directions - p. 151 17. Chapter 9. Novel Chemotherapy Tools: Intraperitoneal Therapy, Dose-Dense Therapy - p. 171 18. Chapter 10. Updates on Rare Epithelial Ovarian Carcinoma - p. 181 19. Part II: Endometrial Cancer - p. 192 20. Chapter 11. Endometrial Cancer Genomics - p. 199 21. Chapter 12. Sentinel Lymph Node Mapping Procedures in Endometrial Cancer - p. 229 22. Chapter 13. The Role of Radiation in Uterine Cancer - p. 241 23. Part III: Cervical Cancer - p. 257 24. Chapter 14. Novel Therapies for Advanced Cervical Cancer - p. 263 25. Part IV: Vulvar Cancer - p. 291 26. Chapter 15. New Therapies in Vulvar Cancer - p. 303 27. Part V: Fertility and Cancer - p. 309 28. Chapter 16. Fertility and Cancer: Fertility Preservation and Fertility Sparing Surgery - p. 315 29. Index - p. 333
Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included.
Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Dedication - p. ii 5. Copyright - p. iv 6. List of Contributors - p. xiii 7. Translational Advances in Gynecologic Cancers - p. xv 8. Part I: Ovarian Cancer - p. xvi 9. Chapter 1. Origins of Epithelial Ovarian Cancer - p. 3 10. Chapter 2. Ovarian Cancer Genomics - p. 19 11. Chapter 3. Epigenetics - p. 35 12. Chapter 4. Timing of Cytoreductive Surgery in the Treatment of Advanced Epithelial Ovarian Carcinoma - p. 59 13. Chapter 5. Angiogenesis - p. 79 14. Chapter 6. Homologous Recombination and BRCA Genes in Ovarian Cancer: Clinical Perspective of Novel Therapeutics - p. 111 15. Chapter 7. Molecular Basis of PARP Inhibition and Future Opportunities in Ovarian Cancer Therapy - p. 129 16. Chapter 8. Ovarian Cancer: New Targets and Future Directions - p. 151 17. Chapter 9. Novel Chemotherapy Tools: Intraperitoneal Therapy, Dose-Dense Therapy - p. 171 18. Chapter 10. Updates on Rare Epithelial Ovarian Carcinoma - p. 181 19. Part II: Endometrial Cancer - p. 192 20. Chapter 11. Endometrial Cancer Genomics - p. 199 21. Chapter 12. Sentinel Lymph Node Mapping Procedures in Endometrial Cancer - p. 229 22. Chapter 13. The Role of Radiation in Uterine Cancer - p. 241 23. Part III: Cervical Cancer - p. 257 24. Chapter 14. Novel Therapies for Advanced Cervical Cancer - p. 263 25. Part IV: Vulvar Cancer - p. 291 26. Chapter 15. New Therapies in Vulvar Cancer - p. 303 27. Part V: Fertility and Cancer - p. 309 28. Chapter 16. Fertility and Cancer: Fertility Preservation and Fertility Sparing Surgery - p. 315 29. Index - p. 333
