Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.
1. Chapter 1. Introduction on translational autoimmunity: From bench to bedside - p. 1 2. Chapter 2. Autophagy in autoimmunity - p. 13 3. Chapter 3. Immunometabolism and autoimmunity - p. 31 4. Chapter 4. T cell recognition of neoepitopes in autoimmunity - p. 47 5. Chapter 5. Role of Th1 and Th2 in autoimmunity - p. 61 6. Chapter 6. Role of Th17 cell in tissue inflammation and organ-specific autoimmunity - p. 112 7. Peptide editing and its modulation in CD4+ T cell tolerance to self - p. 123 8. Chapter 8. Innate lymphoid cells in autoimmune diseases - p. 145 9. Chapter 9. Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades - p. 177 10. Chapter 10. The role of type III interferons in systemic autoimmune diseases - p. 199 11. Chapter 11. Regulation of immunological tolerance and human autoimmunity by NF-κB - p. 214 12. Chapter 12. Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases - p. 235 13. Chapter 13. Human leukocyte antigen and autoimmunity - p. 255 14. Chapter 14. HLA-G-mediated immunological tolerance and autoimmunity - p. 265 15. Chapter 15. The immune system and the microbiota: The two sides of mucosal tolerance - p. 297 16. Chapter 16. Role of free radicals in autoimmune diseases - p. 317 17. Chapter 17. Immunological tolerance and autoimmunity - p. 325 18. Chapter 18. Construction of bioscore for detection of self-tolerance failure: From analysis of silicosis cases - p. 347 19. Index - p. 357
Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.
1. Chapter 1. Introduction on translational autoimmunity: From bench to bedside - p. 1 2. Chapter 2. Autophagy in autoimmunity - p. 13 3. Chapter 3. Immunometabolism and autoimmunity - p. 31 4. Chapter 4. T cell recognition of neoepitopes in autoimmunity - p. 47 5. Chapter 5. Role of Th1 and Th2 in autoimmunity - p. 61 6. Chapter 6. Role of Th17 cell in tissue inflammation and organ-specific autoimmunity - p. 112 7. Peptide editing and its modulation in CD4+ T cell tolerance to self - p. 123 8. Chapter 8. Innate lymphoid cells in autoimmune diseases - p. 145 9. Chapter 9. Autoimmune diseases and the role of Toll-like receptor-7 and -9 signaling cascades - p. 177 10. Chapter 10. The role of type III interferons in systemic autoimmune diseases - p. 199 11. Chapter 11. Regulation of immunological tolerance and human autoimmunity by NF-κB - p. 214 12. Chapter 12. Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases - p. 235 13. Chapter 13. Human leukocyte antigen and autoimmunity - p. 255 14. Chapter 14. HLA-G-mediated immunological tolerance and autoimmunity - p. 265 15. Chapter 15. The immune system and the microbiota: The two sides of mucosal tolerance - p. 297 16. Chapter 16. Role of free radicals in autoimmune diseases - p. 317 17. Chapter 17. Immunological tolerance and autoimmunity - p. 325 18. Chapter 18. Construction of bioscore for detection of self-tolerance failure: From analysis of silicosis cases - p. 347 19. Index - p. 357
