Translational Autoimmunity: Treatment of Autoimmune Diseases, Volume Two in the Translational Immunology series, focuses on advances in therapeutic modalities in autoimmune diseases. Efficacy and safety of not only the current biologic therapies, but also novel drug targets are discussed. Therapeutic targeting of B regulatory cells, T regulatory cells, as well as the immunomodulation effects of nanoparticles and organisms are also covered, along with our understanding and future challenges of prognostic significance of treatments in autoimmune diseases.
1. Chapter 1. Introduction on therapeutic opportunities for autoimmunity - p. 1 2. Chapter 2. Innate lymphoid cells as therapeutic targets in autoimmune diseases - p. 13 3. Chapter 3. B regulatory cells in patients with autoimmune diseases: Pathogenic significance and therapeutic potential - p. 37 4. Chapter 4. Regulatory T cells in autoimmunity and potential therapeutic targets - p. 73 5. Chapter 5. Application of IL-6 antagonists in autoimmune disorders - p. 83 6. Chapter 6. The search for monomer-interaction-based alternative TNF-α therapies - p. 115 7. Chapter 7. Generation of thymic cells from pluripotent stem cells for basic research and cell therapy - p. 135 8. Chapter 8. The NLRP3 inflammasome pathway in autoimmune diseases: a chronotherapeutic perspective? - p. 155 9. Chapter 9. Plasmocyte depletion in autoimmune diseases - p. 179 10. Chapter 10. Biological aging and autoimmunity - p. 197 11. Chapter 11. Efficacy and safety of immune checkpoint inhibitors and cytokine therapy in autoimmune diseases - p. 208 12. Chapter 12. Nutritional implications for the pathophysiology and treatment of autoimmune disorders - p. 243 13. Chapter 13. Dysbiosis and probiotic applications in autoimmune diseases - p. 281 14. Chapter 14. Precision medicine to manage chronic immune-related conditions - p. 295 15. Chapter 15. New advanced therapy medicinal products in treatment of autoimmune diseases - p. 327 16. Chapter 16. Targeting autoimmune disorders through metal nanoformulation in overcoming the fences of conventional treatment approaches - p. 361 17. Chapter 17. Immunomodulatory effects of parasites on autoimmunity - p. 396 18. Chapter 18. Prediction of autoimmune diseases: From bench to bedside - p. 425 19. Index - p. 451
Translational Autoimmunity: Treatment of Autoimmune Diseases, Volume Two in the Translational Immunology series, focuses on advances in therapeutic modalities in autoimmune diseases. Efficacy and safety of not only the current biologic therapies, but also novel drug targets are discussed. Therapeutic targeting of B regulatory cells, T regulatory cells, as well as the immunomodulation effects of nanoparticles and organisms are also covered, along with our understanding and future challenges of prognostic significance of treatments in autoimmune diseases.
1. Chapter 1. Introduction on therapeutic opportunities for autoimmunity - p. 1 2. Chapter 2. Innate lymphoid cells as therapeutic targets in autoimmune diseases - p. 13 3. Chapter 3. B regulatory cells in patients with autoimmune diseases: Pathogenic significance and therapeutic potential - p. 37 4. Chapter 4. Regulatory T cells in autoimmunity and potential therapeutic targets - p. 73 5. Chapter 5. Application of IL-6 antagonists in autoimmune disorders - p. 83 6. Chapter 6. The search for monomer-interaction-based alternative TNF-α therapies - p. 115 7. Chapter 7. Generation of thymic cells from pluripotent stem cells for basic research and cell therapy - p. 135 8. Chapter 8. The NLRP3 inflammasome pathway in autoimmune diseases: a chronotherapeutic perspective? - p. 155 9. Chapter 9. Plasmocyte depletion in autoimmune diseases - p. 179 10. Chapter 10. Biological aging and autoimmunity - p. 197 11. Chapter 11. Efficacy and safety of immune checkpoint inhibitors and cytokine therapy in autoimmune diseases - p. 208 12. Chapter 12. Nutritional implications for the pathophysiology and treatment of autoimmune disorders - p. 243 13. Chapter 13. Dysbiosis and probiotic applications in autoimmune diseases - p. 281 14. Chapter 14. Precision medicine to manage chronic immune-related conditions - p. 295 15. Chapter 15. New advanced therapy medicinal products in treatment of autoimmune diseases - p. 327 16. Chapter 16. Targeting autoimmune disorders through metal nanoformulation in overcoming the fences of conventional treatment approaches - p. 361 17. Chapter 17. Immunomodulatory effects of parasites on autoimmunity - p. 396 18. Chapter 18. Prediction of autoimmune diseases: From bench to bedside - p. 425 19. Index - p. 451
