This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Foreword - p. 6 7. Translational Cancer Research for Surgeons - p. 7 8. Molecular Pathways and the Development of Targeted Therapeutics - p. 8 9. Targeting Angiogenesis and the Tumor Microenvironment - p. 9 10. Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway - p. 16 11. Targeting the Heat Shock Response in Cancer - p. 30 12. Targeting Receptor Tyrosine Kinases in Solid Tumors - p. 42 13. Targeting the NF-κB Pathway in Cancer Therapy - p. 51 14. Targeting the p53 Pathway - p. 74 15. Cancer Immunotherapy - p. 85 16. Clinical Applications of Translational Research - p. 97 17. Translational Research in Melanoma - p. 98 18. Targeted Therapy for Cancer - p. 105 19. Advances in Molecular and Clinical Subtyping of Breast Cancer and Their Implications for Therapy - p. 114 20. Biomarkers and Targeted Therapeutics in Colorectal Cancer - p. 124 21. Translational Research in Endocrine Surgery - p. 133 22. Getting From the Bench to the Patient - p. 151 23. Index - p. 160
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This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Foreword - p. 6 7. Translational Cancer Research for Surgeons - p. 7 8. Molecular Pathways and the Development of Targeted Therapeutics - p. 8 9. Targeting Angiogenesis and the Tumor Microenvironment - p. 9 10. Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway - p. 16 11. Targeting the Heat Shock Response in Cancer - p. 30 12. Targeting Receptor Tyrosine Kinases in Solid Tumors - p. 42 13. Targeting the NF-κB Pathway in Cancer Therapy - p. 51 14. Targeting the p53 Pathway - p. 74 15. Cancer Immunotherapy - p. 85 16. Clinical Applications of Translational Research - p. 97 17. Translational Research in Melanoma - p. 98 18. Targeted Therapy for Cancer - p. 105 19. Advances in Molecular and Clinical Subtyping of Breast Cancer and Their Implications for Therapy - p. 114 20. Biomarkers and Targeted Therapeutics in Colorectal Cancer - p. 124 21. Translational Research in Endocrine Surgery - p. 133 22. Getting From the Bench to the Patient - p. 151 23. Index - p. 160
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