Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish.
All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
1. Chapter 1. Introduction on neuroinflammation - p. 1 2. Chapter 2. Neuroimmune interactions: From bench to bedside - p. 9 3. Chapter 3. Neuroimmunology: Translational lessons from zebrafish models - p. 37 4. Chapter 4. The COVID-19–related neuroinflammation model may reveal relevant information on healthy longevity - p. 47 5. Chapter 5. Role of neural-immune dysregulation in the periphery in the development of age-associated immune dysfunctions - p. 75 6. Chapter 6. Pericytes, a cell type contributing to autoimmunity and immune tolerance - p. 97 7. Chapter 7. Immunity and cognition - p. 129 8. Chapter 8. Neuroimmunology and sleep - p. 151 9. Chapter 9. The impact of systemic inflammation on neuroinflammation - p. 169 10. Chapter 10. Rare autoimmune and autoinflammatory neurologic disorders - p. 189 11. Chapter 11. Epstein-Barr virus and neuroinflammation - p. 221 12. Chapter 12. The potential role of dietary intervention for the treatment of neuroinflammation - p. 243 13. Chapter 13. Immune dysregulation and neurodegenerative diseases - p. 267 14. Chapter 14. Inflammatory and immunological aspects of glaucoma, optic neuritis, and neuromyelitis optica impacting eyesight - p. 299 15. Chapter 15. Imaging characteristics of neuroimmunological disorders - p. 331 16. Chapter 16. Contribution of neuroimaging studies to the understanding of immunology and inflammation in epilepsy - p. 411 17. Chapter 17. Bedside to benchside translation with the targeting of the BAFF/APRIL axis in neurological autoimmune disorders - p. 425 18. Chapter 18. New insights on granulocyte-macrophage colony-stimulating factor (GM-CSF) as potential therapeutic target for immune-mediated neurological disorders - p. 435 19. Chapter 19. Inflammasome elements in epilepsy and seizures - p. 455 20. Chapter 20. Neuroinflammation as a potential therapeutic target in neuroimmunological diseases - p. 477 21. Index - p. 505
Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish.
All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research.
1. Chapter 1. Introduction on neuroinflammation - p. 1 2. Chapter 2. Neuroimmune interactions: From bench to bedside - p. 9 3. Chapter 3. Neuroimmunology: Translational lessons from zebrafish models - p. 37 4. Chapter 4. The COVID-19–related neuroinflammation model may reveal relevant information on healthy longevity - p. 47 5. Chapter 5. Role of neural-immune dysregulation in the periphery in the development of age-associated immune dysfunctions - p. 75 6. Chapter 6. Pericytes, a cell type contributing to autoimmunity and immune tolerance - p. 97 7. Chapter 7. Immunity and cognition - p. 129 8. Chapter 8. Neuroimmunology and sleep - p. 151 9. Chapter 9. The impact of systemic inflammation on neuroinflammation - p. 169 10. Chapter 10. Rare autoimmune and autoinflammatory neurologic disorders - p. 189 11. Chapter 11. Epstein-Barr virus and neuroinflammation - p. 221 12. Chapter 12. The potential role of dietary intervention for the treatment of neuroinflammation - p. 243 13. Chapter 13. Immune dysregulation and neurodegenerative diseases - p. 267 14. Chapter 14. Inflammatory and immunological aspects of glaucoma, optic neuritis, and neuromyelitis optica impacting eyesight - p. 299 15. Chapter 15. Imaging characteristics of neuroimmunological disorders - p. 331 16. Chapter 16. Contribution of neuroimaging studies to the understanding of immunology and inflammation in epilepsy - p. 411 17. Chapter 17. Bedside to benchside translation with the targeting of the BAFF/APRIL axis in neurological autoimmune disorders - p. 425 18. Chapter 18. New insights on granulocyte-macrophage colony-stimulating factor (GM-CSF) as potential therapeutic target for immune-mediated neurological disorders - p. 435 19. Chapter 19. Inflammasome elements in epilepsy and seizures - p. 455 20. Chapter 20. Neuroinflammation as a potential therapeutic target in neuroimmunological diseases - p. 477 21. Index - p. 505
