Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Part A: Islet auto-transplantation - p. xiv 7. Section I: Chronic pancreatitis - p. xiv 8. Chapter 1: Etiopathogenesis and pathophysiology of chronic pancreatitis - p. xiv 9. Chapter 2: Nonreplacement treatment of chronic pancreatitis: Conservative, endoscopic, and surgical (resection and drainage procedures) - p. 32 10. Section II: Islet auto-transplantation for chronic pancreatitis - p. 48 11. Chapter 3: Requirements for clinical islet laboratories - p. 48 12. Chapter 4: Islet isolation for autotransplantation, following total or near total pancreatectomy - p. 66 13. Chapter 5: Strategies to improve islet yield from chronic pancreatitis pancreases intended for islet autotransplantation - p. 87 14. Chapter 6: Surgical techniques for total pancreatectomy and islet autotransplantation - p. 99 15. Chapter 7: Total pancreatectomy with islet autotransplantation in children - p. 116 16. Chapter 8: Islet autotransplantation: Indication beyond chronic pancreatitis - p. 126 17. Section III: Outcomes - p. 137 18. Chapter 9: Postoperative care and prevention and treatment of complications following total pancreatectomy with islet cell autotransplantation - p. 137 19. Chapter 10: Metabolic outcomes after total pancreatectomy followed by islet autotransplantation (TPIAT): Mixed blessings - p. 148 20. Chapter 11: Long-term results of TPIAT - p. 155 21. Part B: Bioengineering and regeneration of the endocrine pancreas - p. 166 22. Section I: Pancreas development and regeneration - p. 166 23. Chapter 12: Embryonic development of the endocrine pancreas - p. 166 24. Chapter 13: Human pancreatic progenitors - p. 182 25. Chapter 14: Strategies to promote beta-cell replication and regeneration - p. 200 26. Chapter 15: Diet as a therapeutic approach to diabetes management and pancreas regeneration - p. 213 27. Chapter 16: The benefits of metabolic/bariatric surgery on diabetes mellitus - p. 227 28. Section II: Scaffolds for endocrine pancreas bioengineering - p. 240 29. Chapter 17: ECM-based scaffolds for pancreas bioengineering - p. 240 30. Chapter 18: Plasma scaffolds for islet transplantation - p. 255 31. Chapter 19: A biologic resorbable scaffold for tissue engineering of the endocrine pancreas: Clinical experience of islet transplantation on the omentum - p. 268 32. Chapter 20: Endothelialized collagen modules for islet tissue engineering - p. 276 33. Section III: Islet encapsulation - p. 287 34. Chapter 21: Conformal coating - p. 287 35. Chapter 22: Co-encapsulation of ECM proteins to enhance pancreatic islet cell function - p. 306 36. Chapter 23: Co-encapsulation of mesenchymal stromal cells to enhance islet function - p. 313 37. Chapter 24: Silk-based encapsulation materials to enhance pancreatic cell functions - p. 328 38. Chapter 25: Cell pouch devices - p. 337 39. Section IV: Stem cells to generate insulin producing cells - p. 343 40. Chapter 26: Pancreas progenitors - p. 343 41. Chapter 27: Human embryonic stem cells (hESC) as a source of insulin-producing cells - p. 357 42. Chapter 28: Human-induced pluripotent stem cells (iPSC) as a source of insulin-producing cells - p. 379 43. Chapter 29: Ductal cell reprograming to insulin-producing cells as a potential beta cell replacement source for islet auto-transplant recipients - p. 396 44. Chapter 30: Synthetic biology technologies for beta cell generation - p. 405 45. Section V: Animal-based platforms for pancreas bioengineering - p. 420 46. Chapter 31: Xenotransplantation of the endocrine pancreas - p. 420 47. Chapter 32: Interspecies blastocyst complementation - p. 446 48. Section VI: Tissue engineering technologies applied to ß-cell replacement - p. 457 49. Chapter 33: Bioengineering, biomaterials, and β-cell replacement therapy - p. 457 50. Chapter 34: Subcutaneous islet transplantation using tissue-engineered sheets - p. 486 51. Section VII: Regulation and funding - p. 495 52. Chapter 35: Regulation for regenerative medicine-based therapies - p. 495 53. Chapter 36: Catalyzing beta-cell replacement research to achieve insulin independence in type 1 diabetes: Goals and priorities - p. 503 54. Chapter 37: Regenerative medicine technologies applied to beta cell replacement: The industry perspective - p. 517 55. Chapter 38: Pancreas whole organ engineering - p. 526 56. Index - p. 537
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Part A: Islet auto-transplantation - p. xiv 7. Section I: Chronic pancreatitis - p. xiv 8. Chapter 1: Etiopathogenesis and pathophysiology of chronic pancreatitis - p. xiv 9. Chapter 2: Nonreplacement treatment of chronic pancreatitis: Conservative, endoscopic, and surgical (resection and drainage procedures) - p. 32 10. Section II: Islet auto-transplantation for chronic pancreatitis - p. 48 11. Chapter 3: Requirements for clinical islet laboratories - p. 48 12. Chapter 4: Islet isolation for autotransplantation, following total or near total pancreatectomy - p. 66 13. Chapter 5: Strategies to improve islet yield from chronic pancreatitis pancreases intended for islet autotransplantation - p. 87 14. Chapter 6: Surgical techniques for total pancreatectomy and islet autotransplantation - p. 99 15. Chapter 7: Total pancreatectomy with islet autotransplantation in children - p. 116 16. Chapter 8: Islet autotransplantation: Indication beyond chronic pancreatitis - p. 126 17. Section III: Outcomes - p. 137 18. Chapter 9: Postoperative care and prevention and treatment of complications following total pancreatectomy with islet cell autotransplantation - p. 137 19. Chapter 10: Metabolic outcomes after total pancreatectomy followed by islet autotransplantation (TPIAT): Mixed blessings - p. 148 20. Chapter 11: Long-term results of TPIAT - p. 155 21. Part B: Bioengineering and regeneration of the endocrine pancreas - p. 166 22. Section I: Pancreas development and regeneration - p. 166 23. Chapter 12: Embryonic development of the endocrine pancreas - p. 166 24. Chapter 13: Human pancreatic progenitors - p. 182 25. Chapter 14: Strategies to promote beta-cell replication and regeneration - p. 200 26. Chapter 15: Diet as a therapeutic approach to diabetes management and pancreas regeneration - p. 213 27. Chapter 16: The benefits of metabolic/bariatric surgery on diabetes mellitus - p. 227 28. Section II: Scaffolds for endocrine pancreas bioengineering - p. 240 29. Chapter 17: ECM-based scaffolds for pancreas bioengineering - p. 240 30. Chapter 18: Plasma scaffolds for islet transplantation - p. 255 31. Chapter 19: A biologic resorbable scaffold for tissue engineering of the endocrine pancreas: Clinical experience of islet transplantation on the omentum - p. 268 32. Chapter 20: Endothelialized collagen modules for islet tissue engineering - p. 276 33. Section III: Islet encapsulation - p. 287 34. Chapter 21: Conformal coating - p. 287 35. Chapter 22: Co-encapsulation of ECM proteins to enhance pancreatic islet cell function - p. 306 36. Chapter 23: Co-encapsulation of mesenchymal stromal cells to enhance islet function - p. 313 37. Chapter 24: Silk-based encapsulation materials to enhance pancreatic cell functions - p. 328 38. Chapter 25: Cell pouch devices - p. 337 39. Section IV: Stem cells to generate insulin producing cells - p. 343 40. Chapter 26: Pancreas progenitors - p. 343 41. Chapter 27: Human embryonic stem cells (hESC) as a source of insulin-producing cells - p. 357 42. Chapter 28: Human-induced pluripotent stem cells (iPSC) as a source of insulin-producing cells - p. 379 43. Chapter 29: Ductal cell reprograming to insulin-producing cells as a potential beta cell replacement source for islet auto-transplant recipients - p. 396 44. Chapter 30: Synthetic biology technologies for beta cell generation - p. 405 45. Section V: Animal-based platforms for pancreas bioengineering - p. 420 46. Chapter 31: Xenotransplantation of the endocrine pancreas - p. 420 47. Chapter 32: Interspecies blastocyst complementation - p. 446 48. Section VI: Tissue engineering technologies applied to ß-cell replacement - p. 457 49. Chapter 33: Bioengineering, biomaterials, and β-cell replacement therapy - p. 457 50. Chapter 34: Subcutaneous islet transplantation using tissue-engineered sheets - p. 486 51. Section VII: Regulation and funding - p. 495 52. Chapter 35: Regulation for regenerative medicine-based therapies - p. 495 53. Chapter 36: Catalyzing beta-cell replacement research to achieve insulin independence in type 1 diabetes: Goals and priorities - p. 503 54. Chapter 37: Regenerative medicine technologies applied to beta cell replacement: The industry perspective - p. 517 55. Chapter 38: Pancreas whole organ engineering - p. 526 56. Index - p. 537
