Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine.
1. Section I: Introduction - p. xxiii 2. Chapter 1: History of pancreas transplantation - p. xxiii 3. Chapter 2: How to build a pancreas transplant program - p. 27 4. Chapter 3: Pathophysiology of diabetes - p. 36 5. Chapter 4: Epidemiology of diabetes mellitus - p. 47 6. Section II: The donor - p. 58 7. Chapter 5: Pancreas donor selection - p. 58 8. Chapter 6: Deceased donor pancreas procurement - p. 67 9. Chapter 7: Surgical techniques for living donor pancreas transplantation - p. 79 10. Chapter 8: Pancreas preservation - p. 95 11. Chapter 9: Pancreas graft back-table surgery technique - p. 104 12. Section III: The recipient - p. 112 13. Chapter 10: Pancreas transplant alone - p. 112 14. Chapter 11: Pancreas after kidney transplantation - p. 124 15. Chapter 12: Simultaneous pancreas-kidney transplantation - p. 132 16. Chapter 13: Surgical techniques for deceased donor pancreas transplantation - p. 148 17. Chapter 14: Robotic pancreas transplantation - p. 167 18. Chapter 15: Pancreas transplantation in the setting of multivisceral transplantation - p. 177 19. Chapter 16: Imaging in pancreas transplantation - p. 193 20. Chapter 17: Postoperative care of the pancreas transplant patient - p. 207 21. Chapter 18: Immunosuppression for pancreas allo-transplantation - p. 216 22. Section IV: Complications after pancreas allo-transplantation - p. 228 23. Chapter 19: Infectious complications after pancreas allotransplantation - p. 228 24. Chapter 20: Medical complications after pancreas transplantation - p. 237 25. Chapter 21: Technical complications of pancreas allotransplantation - p. 246 26. Chapter 22: Pancreas transplantation, bioengineering, and regeneration - p. 258 27. Section V: Natural history - p. 276 28. Chapter 23: Reversal of secondary complications of type 1 diabetes (nephropathy, neuropathy, retinopathy, and cardiopathy) - p. 276 29. Chapter 24: Recurrence of type 1 diabetes following simultaneous pancreas-kidney transplantation - p. 293 30. Chapter 25: Pathological evaluation of whole pancreas transplants - p. 311 31. Chapter 26: Failure of the pancreas allograft - p. 327 32. Chapter 27: Pancreas retransplantation - p. 338 33. Section VI: State of the art of pancreas transplantation - p. 346 34. Chapter 28: The current state of pancreas transplantation in the United States—A registry report - p. 346 35. Chapter 29: Trends in pancreas transplantation in the United States - p. 358 36. Chapter 30: Experimental pancreas transplantation - p. 364 37. Chapter 31: Pancreas transplantation: Current issues, unmet needs, and future perspectives - p. 373 38. Part B: Islet allo-transplantation - p. 386 39. Section I: Introduction and indications - p. 386 40. Chapter 32: Treatment of type 1 diabetes complicated by problematic hypoglycemia - p. 386 41. Chapter 33: Eligibility of patients with type 1 diabetes for islet transplantation alone - p. 406 42. Chapter 34: Islet vs pancreas transplantation in nonuremic patients with type 1 diabetes - p. 416 43. Chapter 35: Simultaneous islet-kidney and islet-after-kidney transplantation - p. 423 44. Chapter 36: Pancreatic islet transplantation in cystic fibrosis: Lung and islet transplantation - p. 432 45. Chapter 37: Combined liver and islet transplantation in hepatogenous diabetes, cluster exenteration, and cirrhosis with type 1 diabetes - p. 438 46. Section II: Donor selection - p. 453 47. Chapter 38: Evolving approaches to organ allocation for the whole pancreas vs islet transplantation - p. 453 48. Chapter 39: Living donors - p. 463 49. Chapter 40: Pancreatic islet isolation from donation after circulatory death pancreas - p. 469 50. Section III: Islet isolation - p. 482 51. Chapter 41: Factors related to successful clinical islet isolation - p. 482 52. Chapter 42: Pancreas and islet preservation - p. 502 53. Chapter 43: Collagenases in pancreatic islet isolation - p. 527 54. Chapter 44: Predicting the function of islets after transplantation - p. 546 55. Section IV: Outcomes after allogeneic pancreatic islet transplantation - p. 561 56. Chapter 45: Metabolic and endocrine evaluation of islet transplant function - p. 561 57. Chapter 46: Procedure-related and medical complications in and after intraportal islet transplantation - p. 578 58. Chapter 47: Secondary complications of diabetes - p. 590 59. Section V: Current clinical results - p. 595 60. Chapter 48: Treating diabetes with islet transplantation: Lessons learnt from the Nordic network for clinical islet transplantation - p. 595 61. Chapter 49: UK’s nationally funded integrated islet transplant program - p. 611 62. Chapter 50: Type 1 diabetes transplanted with allogenic islets within the Swiss-French GRAGIL network - p. 623 63. Chapter 51: Optimizing primary graft function in islet allotransplantation: The Lille experience - p. 635 64. Chapter 52: Treating diabetes with islet transplantation: Lessons from the Milan experience - p. 643 65. Chapter 53: Treating diabetes with islet transplantation: Lessons from the University of Miami - p. 658 66. Chapter 54: Treating diabetes with islet cell transplantation: Lessons from the Edmonton experience - p. 670 67. Section VI: Monitoring of allogeneic islet grafts - p. 684 68. Chapter 55: Immune monitoring of allogeneic islets - p. 684 69. Chapter 56: Markers for beta-cell loss - p. 693 70. Chapter 57: In vivo quality control of human islets in the immunodeficient mouse to predict islet function in man: A retrospective study in 87 clinical transplants - p. 709 71. Section VII: Immunomodulatory technologies applied to islet transplantation - p. 724 72. Chapter 58: Progress toward islet transplantation tolerance - p. 724 73. Chapter 59: Filling the gap to improve islet engraftment and survival using anti-inflammatory approaches - p. 739 74. Chapter 60: Islet immunoisolation by macroencapsulation - p. 750 75. Chapter 61: Islet immunoisolation by microencapsulation - p. 759 76. Chapter 62: Recurrence of type 1 diabetes after beta-cell replacement - p. 786 77. Section VIII: Cellular therapies in preclinical and clinical islet transplantation - p. 796 78. Chapter 63: T regulatory cell therapy in preclinical and clinical pancreatic islet transplantation - p. 796 79. Chapter 64: Cellular therapies in preclinical and clinical islet transplantation: Mesenchymal stem cells - p. 819 80. Chapter 65: Alternative transplantation sites for islet transplantation - p. 831 81. Index - p. 849
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine.
1. Section I: Introduction - p. xxiii 2. Chapter 1: History of pancreas transplantation - p. xxiii 3. Chapter 2: How to build a pancreas transplant program - p. 27 4. Chapter 3: Pathophysiology of diabetes - p. 36 5. Chapter 4: Epidemiology of diabetes mellitus - p. 47 6. Section II: The donor - p. 58 7. Chapter 5: Pancreas donor selection - p. 58 8. Chapter 6: Deceased donor pancreas procurement - p. 67 9. Chapter 7: Surgical techniques for living donor pancreas transplantation - p. 79 10. Chapter 8: Pancreas preservation - p. 95 11. Chapter 9: Pancreas graft back-table surgery technique - p. 104 12. Section III: The recipient - p. 112 13. Chapter 10: Pancreas transplant alone - p. 112 14. Chapter 11: Pancreas after kidney transplantation - p. 124 15. Chapter 12: Simultaneous pancreas-kidney transplantation - p. 132 16. Chapter 13: Surgical techniques for deceased donor pancreas transplantation - p. 148 17. Chapter 14: Robotic pancreas transplantation - p. 167 18. Chapter 15: Pancreas transplantation in the setting of multivisceral transplantation - p. 177 19. Chapter 16: Imaging in pancreas transplantation - p. 193 20. Chapter 17: Postoperative care of the pancreas transplant patient - p. 207 21. Chapter 18: Immunosuppression for pancreas allo-transplantation - p. 216 22. Section IV: Complications after pancreas allo-transplantation - p. 228 23. Chapter 19: Infectious complications after pancreas allotransplantation - p. 228 24. Chapter 20: Medical complications after pancreas transplantation - p. 237 25. Chapter 21: Technical complications of pancreas allotransplantation - p. 246 26. Chapter 22: Pancreas transplantation, bioengineering, and regeneration - p. 258 27. Section V: Natural history - p. 276 28. Chapter 23: Reversal of secondary complications of type 1 diabetes (nephropathy, neuropathy, retinopathy, and cardiopathy) - p. 276 29. Chapter 24: Recurrence of type 1 diabetes following simultaneous pancreas-kidney transplantation - p. 293 30. Chapter 25: Pathological evaluation of whole pancreas transplants - p. 311 31. Chapter 26: Failure of the pancreas allograft - p. 327 32. Chapter 27: Pancreas retransplantation - p. 338 33. Section VI: State of the art of pancreas transplantation - p. 346 34. Chapter 28: The current state of pancreas transplantation in the United States—A registry report - p. 346 35. Chapter 29: Trends in pancreas transplantation in the United States - p. 358 36. Chapter 30: Experimental pancreas transplantation - p. 364 37. Chapter 31: Pancreas transplantation: Current issues, unmet needs, and future perspectives - p. 373 38. Part B: Islet allo-transplantation - p. 386 39. Section I: Introduction and indications - p. 386 40. Chapter 32: Treatment of type 1 diabetes complicated by problematic hypoglycemia - p. 386 41. Chapter 33: Eligibility of patients with type 1 diabetes for islet transplantation alone - p. 406 42. Chapter 34: Islet vs pancreas transplantation in nonuremic patients with type 1 diabetes - p. 416 43. Chapter 35: Simultaneous islet-kidney and islet-after-kidney transplantation - p. 423 44. Chapter 36: Pancreatic islet transplantation in cystic fibrosis: Lung and islet transplantation - p. 432 45. Chapter 37: Combined liver and islet transplantation in hepatogenous diabetes, cluster exenteration, and cirrhosis with type 1 diabetes - p. 438 46. Section II: Donor selection - p. 453 47. Chapter 38: Evolving approaches to organ allocation for the whole pancreas vs islet transplantation - p. 453 48. Chapter 39: Living donors - p. 463 49. Chapter 40: Pancreatic islet isolation from donation after circulatory death pancreas - p. 469 50. Section III: Islet isolation - p. 482 51. Chapter 41: Factors related to successful clinical islet isolation - p. 482 52. Chapter 42: Pancreas and islet preservation - p. 502 53. Chapter 43: Collagenases in pancreatic islet isolation - p. 527 54. Chapter 44: Predicting the function of islets after transplantation - p. 546 55. Section IV: Outcomes after allogeneic pancreatic islet transplantation - p. 561 56. Chapter 45: Metabolic and endocrine evaluation of islet transplant function - p. 561 57. Chapter 46: Procedure-related and medical complications in and after intraportal islet transplantation - p. 578 58. Chapter 47: Secondary complications of diabetes - p. 590 59. Section V: Current clinical results - p. 595 60. Chapter 48: Treating diabetes with islet transplantation: Lessons learnt from the Nordic network for clinical islet transplantation - p. 595 61. Chapter 49: UK’s nationally funded integrated islet transplant program - p. 611 62. Chapter 50: Type 1 diabetes transplanted with allogenic islets within the Swiss-French GRAGIL network - p. 623 63. Chapter 51: Optimizing primary graft function in islet allotransplantation: The Lille experience - p. 635 64. Chapter 52: Treating diabetes with islet transplantation: Lessons from the Milan experience - p. 643 65. Chapter 53: Treating diabetes with islet transplantation: Lessons from the University of Miami - p. 658 66. Chapter 54: Treating diabetes with islet cell transplantation: Lessons from the Edmonton experience - p. 670 67. Section VI: Monitoring of allogeneic islet grafts - p. 684 68. Chapter 55: Immune monitoring of allogeneic islets - p. 684 69. Chapter 56: Markers for beta-cell loss - p. 693 70. Chapter 57: In vivo quality control of human islets in the immunodeficient mouse to predict islet function in man: A retrospective study in 87 clinical transplants - p. 709 71. Section VII: Immunomodulatory technologies applied to islet transplantation - p. 724 72. Chapter 58: Progress toward islet transplantation tolerance - p. 724 73. Chapter 59: Filling the gap to improve islet engraftment and survival using anti-inflammatory approaches - p. 739 74. Chapter 60: Islet immunoisolation by macroencapsulation - p. 750 75. Chapter 61: Islet immunoisolation by microencapsulation - p. 759 76. Chapter 62: Recurrence of type 1 diabetes after beta-cell replacement - p. 786 77. Section VIII: Cellular therapies in preclinical and clinical islet transplantation - p. 796 78. Chapter 63: T regulatory cell therapy in preclinical and clinical pancreatic islet transplantation - p. 796 79. Chapter 64: Cellular therapies in preclinical and clinical islet transplantation: Mesenchymal stem cells - p. 819 80. Chapter 65: Alternative transplantation sites for islet transplantation - p. 831 81. Index - p. 849
