TRP Channels as Therapeutic Targets, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. The Editor lined up a team of worldwide experts in academia and corporate R&D to provide diverse views into these promising drug development targets.
Following the research development happened in the past ten years, since the first edition published, the revision includes seven new chapters. All remaining chapters are completely updated. New topics included in the book are TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation.
TRP Channels as Therapeutic Targets, Second Edition is a reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline, will find in this book their biologic principles of action.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xv 7. Preface - p. xviii 8. Chapter 1. Opening remarks: What makes TRP channels attractive therapeutic targets? - p. 1 9. Chapter 2. Biology of TRP channels - p. 9 10. Chapter 3. Targeting TRP channels: The emerging role of cryogenic electron microscopy in drug discovery - p. 35 11. Chapter 4. Thermo-TRPs: Temperature-sensitive TRP channels - p. 53 12. Chapter 5. “TRP channelopathies”: TRP channel dysfunction in hereditary diseases - p. 71 13. Chapter 6. Current understanding of TRP channels and their genomics: Implications in health research - p. 81 14. Chapter 7. TRP channel drug discovery strategies - p. 103 15. Chapter 8. High-dose capsaicin patch for pain relief: Clinical experience - p. 115 16. Chapter 9. Therapeutic uses of injectable capsaicin for pain - p. 143 17. Chapter 10. Resiniferatoxin for permanent pain relief in cancer patients - p. 155 18. Chapter 11. TRPV1 antagonists: Future drug discovery directions - p. 163 19. Chapter 12. TRPA1 antagonists for pain relief - p. 185 20. Chapter 13. TRPM3: An emerging pain target (and more) - p. 203 21. Chapter 14. TRP channels and migraine - p. 217 22. Chapter 15. TRP channels in the GU tract - p. 229 23. Chapter 16. TRP channels in respiratory disorders - p. 257 24. Chapter 17. TRP channels: Emerging targets in COVID-19 and its complications - p. 281 25. Chapter 18. TRP channels in cardiovascular disease - p. 303 26. Chapter 19. TRP channels in cerebral vascular disorders - p. 325 27. Chapter 20. TRPV1 in blood pressure regulation: A new therapeutic target in hypertension? - p. 343 28. Chapter 21. Activating, inhibiting, and hijacking TRP channels for relief from itch - p. 355 29. Chapter 22. TRP channels in dermatology - p. 365 30. Chapter 23. Transient Receptor Potential (TRP) channels in cancer: Implications for drug discovery and development - p. 387 31. Chapter 24. TRP channel expression in the tumor microenvironment: Implications for tumor progression and metastasis - p. 403 32. Chapter 25. TRP channels as potential target molecules for pharmacotherapy of neurological diseases - p. 421 33. Chapter 26. Targeting TRP channels for anxiety relief and improving mental health - p. 457 34. Chapter 27. Potential of agents that modulate transient receptor potential (TRP) channels as therapies in arthritis - p. 473 35. Chapter 28. TRP channels as molecular targets to relieve endocrine-related diseases - p. 483 36. Chapter 29. Transient receptor potential (TRP) channels in metabolic syndrome - p. 517 37. Chapter 30. TRP channels in renal disease. Lessons from Polycystin-2 (TRPP2) - p. 533 38. Chapter 31. TRP channels and thermoregulation; therapeutic opportunities - p. 551 39. Chapter 32. Concluding remarks: Past, present, future - p. 565 40. Index - p. 573
TRP Channels as Therapeutic Targets, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. The Editor lined up a team of worldwide experts in academia and corporate R&D to provide diverse views into these promising drug development targets.
Following the research development happened in the past ten years, since the first edition published, the revision includes seven new chapters. All remaining chapters are completely updated. New topics included in the book are TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation.
TRP Channels as Therapeutic Targets, Second Edition is a reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline, will find in this book their biologic principles of action.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xv 7. Preface - p. xviii 8. Chapter 1. Opening remarks: What makes TRP channels attractive therapeutic targets? - p. 1 9. Chapter 2. Biology of TRP channels - p. 9 10. Chapter 3. Targeting TRP channels: The emerging role of cryogenic electron microscopy in drug discovery - p. 35 11. Chapter 4. Thermo-TRPs: Temperature-sensitive TRP channels - p. 53 12. Chapter 5. “TRP channelopathies”: TRP channel dysfunction in hereditary diseases - p. 71 13. Chapter 6. Current understanding of TRP channels and their genomics: Implications in health research - p. 81 14. Chapter 7. TRP channel drug discovery strategies - p. 103 15. Chapter 8. High-dose capsaicin patch for pain relief: Clinical experience - p. 115 16. Chapter 9. Therapeutic uses of injectable capsaicin for pain - p. 143 17. Chapter 10. Resiniferatoxin for permanent pain relief in cancer patients - p. 155 18. Chapter 11. TRPV1 antagonists: Future drug discovery directions - p. 163 19. Chapter 12. TRPA1 antagonists for pain relief - p. 185 20. Chapter 13. TRPM3: An emerging pain target (and more) - p. 203 21. Chapter 14. TRP channels and migraine - p. 217 22. Chapter 15. TRP channels in the GU tract - p. 229 23. Chapter 16. TRP channels in respiratory disorders - p. 257 24. Chapter 17. TRP channels: Emerging targets in COVID-19 and its complications - p. 281 25. Chapter 18. TRP channels in cardiovascular disease - p. 303 26. Chapter 19. TRP channels in cerebral vascular disorders - p. 325 27. Chapter 20. TRPV1 in blood pressure regulation: A new therapeutic target in hypertension? - p. 343 28. Chapter 21. Activating, inhibiting, and hijacking TRP channels for relief from itch - p. 355 29. Chapter 22. TRP channels in dermatology - p. 365 30. Chapter 23. Transient Receptor Potential (TRP) channels in cancer: Implications for drug discovery and development - p. 387 31. Chapter 24. TRP channel expression in the tumor microenvironment: Implications for tumor progression and metastasis - p. 403 32. Chapter 25. TRP channels as potential target molecules for pharmacotherapy of neurological diseases - p. 421 33. Chapter 26. Targeting TRP channels for anxiety relief and improving mental health - p. 457 34. Chapter 27. Potential of agents that modulate transient receptor potential (TRP) channels as therapies in arthritis - p. 473 35. Chapter 28. TRP channels as molecular targets to relieve endocrine-related diseases - p. 483 36. Chapter 29. Transient receptor potential (TRP) channels in metabolic syndrome - p. 517 37. Chapter 30. TRP channels in renal disease. Lessons from Polycystin-2 (TRPP2) - p. 533 38. Chapter 31. TRP channels and thermoregulation; therapeutic opportunities - p. 551 39. Chapter 32. Concluding remarks: Past, present, future - p. 565 40. Index - p. 573
