Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xv 8. About the editors - p. xxi 9. Preface - p. xxiii 10. Section 1: Extracellular vesicles/exosomes as novel sources of cellular communication - p. S1 11. Chapter 1. Historical context and the evolution of exosome research - p. 3 12. Chapter 2. The cellular machinery behind exosome formation - p. 35 13. Chapter 3. Exosomes as messengers: intercellular communication - p. 63 14. Chapter 4. Exosomes: essential messengers in intercellular communication - p. 93 15. Chapter 5. Exosomes as cellular couriers: the mechanisms of intercellular messaging - p. 105 16. Section 2: Extracellular vesicles/exosomes: methods and protocols - p. S129 17. Chapter 6. Comprehensive approaches to isolation, characterization, and functional assessment of extracellular vesicles - p. 131 18. Section 3: Extracellular vesicles/exosomes in health and diseases: Potential applications - p. S155 19. Chapter 7. Exosomes as biomarkers for disease diagnosis - p. 157 20. Chapter 8. The intricate interplay between cancer cells and exosomes - p. 181 21. Chapter 9. Advancements in stem cell therapy facilitated by exosomes - p. 195 22. Chapter 10. Crossing the blood–brain barrier: exosomes in neurological research - p. 213 23. Chapter 11. Exosomes as vectors across the blood–brain barrier in neurological research - p. 229 24. Chapter 12. Unraveling the role of exosomes in modulating immune responses - p. 259 25. Chapter 13. The immunological impact of exosomes: modulation and mechanisms - p. 281 26. Chapter 14. Exploring the link between exosomes and metabolic diseases - p. 329 27. Chapter 15. Role of exosomal microRNAs in anticancer drug resistance and tumor angiogenesis - p. 349 28. Chapter 16. Health implications of retinoic acid in exosome biogenesis, secretion, and uptake - p. 371 29. Chapter 17. Exosomes in aging and longevity - p. 381 30. Section 4: Engineering and scaling up extracellular vesicles and exosomes production: Medicine, nutraceuticals, cosmetics, and novel applications - p. S411 31. Chapter 18. Cutting-edge technology for extracellular vesicles and exosomes production: future prospects - p. 413 32. Chapter 19. Novel application of extracellular vesicles and exosomes in nutraceutical and cosmetic production - p. 431 33. Chapter 20. Ethical considerations, challenges, and the road ahead: exosomes in the next decade - p. 457 34. Index - p. 481
Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xv 8. About the editors - p. xxi 9. Preface - p. xxiii 10. Section 1: Extracellular vesicles/exosomes as novel sources of cellular communication - p. S1 11. Chapter 1. Historical context and the evolution of exosome research - p. 3 12. Chapter 2. The cellular machinery behind exosome formation - p. 35 13. Chapter 3. Exosomes as messengers: intercellular communication - p. 63 14. Chapter 4. Exosomes: essential messengers in intercellular communication - p. 93 15. Chapter 5. Exosomes as cellular couriers: the mechanisms of intercellular messaging - p. 105 16. Section 2: Extracellular vesicles/exosomes: methods and protocols - p. S129 17. Chapter 6. Comprehensive approaches to isolation, characterization, and functional assessment of extracellular vesicles - p. 131 18. Section 3: Extracellular vesicles/exosomes in health and diseases: Potential applications - p. S155 19. Chapter 7. Exosomes as biomarkers for disease diagnosis - p. 157 20. Chapter 8. The intricate interplay between cancer cells and exosomes - p. 181 21. Chapter 9. Advancements in stem cell therapy facilitated by exosomes - p. 195 22. Chapter 10. Crossing the blood–brain barrier: exosomes in neurological research - p. 213 23. Chapter 11. Exosomes as vectors across the blood–brain barrier in neurological research - p. 229 24. Chapter 12. Unraveling the role of exosomes in modulating immune responses - p. 259 25. Chapter 13. The immunological impact of exosomes: modulation and mechanisms - p. 281 26. Chapter 14. Exploring the link between exosomes and metabolic diseases - p. 329 27. Chapter 15. Role of exosomal microRNAs in anticancer drug resistance and tumor angiogenesis - p. 349 28. Chapter 16. Health implications of retinoic acid in exosome biogenesis, secretion, and uptake - p. 371 29. Chapter 17. Exosomes in aging and longevity - p. 381 30. Section 4: Engineering and scaling up extracellular vesicles and exosomes production: Medicine, nutraceuticals, cosmetics, and novel applications - p. S411 31. Chapter 18. Cutting-edge technology for extracellular vesicles and exosomes production: future prospects - p. 413 32. Chapter 19. Novel application of extracellular vesicles and exosomes in nutraceutical and cosmetic production - p. 431 33. Chapter 20. Ethical considerations, challenges, and the road ahead: exosomes in the next decade - p. 457 34. Index - p. 481
