Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.
The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.
This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.
1. Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of contributors - p. ix 7. Preface - p. xv 8. Chapter 1 Role of TRAIL-mediated signaling as Jekyll and Hyde in metastasis - p. 1 9. Chapter 2 Multiple roles of circulating tumor cells and exosomes in cancer metastasis - p. 7 10. Chapter 3 Diagnosis and treatment of metastatic prostate cancer - p. 23 11. Chapter 4 Prognostic and predictive role of bone metastasis in NSCLC - p. 49 12. Chapter 5 Brain metastases in breast cancer - p. 63 13. Chapter 6 Noncoding way of the metastasis - p. 87 14. Chapter 7 Nanotechnology based docetaxel - p. 105 15. Chapter 8 Metastasis in gynecological cancers - p. 125 16. Chapter 9 Regulation of HSP90 by noncoding RNAs in carcinogenesis and metastasis - p. 137 17. Chapter 10 Role of circular RNAs in carcinogenesis and metastasis - p. 145 18. Chapter 11 Metastatic potential - p. 153 19. Chapter 12 Developmental genes - p. 175 20. Chapter 13 Heat shock proteins in tumor progression and metastasis - p. 187 21. Chapter 14 Role of kisspeptin-mediated signaling pathway in carcinogenesis and metastasis - p. 203 22. Chapter 15 Tumor microenvironment manipulation and cancer metastasis (taming the beast) - p. 209 23. Chapter 16 Metastasis inhibitory role of hydroxycinnamic acid and its derivatives - p. 235 24. Chapter 17 Regulatory role of SMURF1 and SMURF2 in metastasis - p. 241 25. Chapter 18 Antimetastatic effects of curcumin - p. 249 26. Chapter 19 Metastasis inhibitory role of blueberries - p. 259 27. Chapter 20 The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior - p. 265 28. Chapter 21 The role of epigenetics in cancer metastasis - p. 277 29. Chapter 22 Regulation of angiogenesis in tumor metastasis via Ets-related ERG and micro-RNAs; one hand washes the other - p. 301 30. Index - p. 317
Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.
The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.
This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.
1. Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of contributors - p. ix 7. Preface - p. xv 8. Chapter 1 Role of TRAIL-mediated signaling as Jekyll and Hyde in metastasis - p. 1 9. Chapter 2 Multiple roles of circulating tumor cells and exosomes in cancer metastasis - p. 7 10. Chapter 3 Diagnosis and treatment of metastatic prostate cancer - p. 23 11. Chapter 4 Prognostic and predictive role of bone metastasis in NSCLC - p. 49 12. Chapter 5 Brain metastases in breast cancer - p. 63 13. Chapter 6 Noncoding way of the metastasis - p. 87 14. Chapter 7 Nanotechnology based docetaxel - p. 105 15. Chapter 8 Metastasis in gynecological cancers - p. 125 16. Chapter 9 Regulation of HSP90 by noncoding RNAs in carcinogenesis and metastasis - p. 137 17. Chapter 10 Role of circular RNAs in carcinogenesis and metastasis - p. 145 18. Chapter 11 Metastatic potential - p. 153 19. Chapter 12 Developmental genes - p. 175 20. Chapter 13 Heat shock proteins in tumor progression and metastasis - p. 187 21. Chapter 14 Role of kisspeptin-mediated signaling pathway in carcinogenesis and metastasis - p. 203 22. Chapter 15 Tumor microenvironment manipulation and cancer metastasis (taming the beast) - p. 209 23. Chapter 16 Metastasis inhibitory role of hydroxycinnamic acid and its derivatives - p. 235 24. Chapter 17 Regulatory role of SMURF1 and SMURF2 in metastasis - p. 241 25. Chapter 18 Antimetastatic effects of curcumin - p. 249 26. Chapter 19 Metastasis inhibitory role of blueberries - p. 259 27. Chapter 20 The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior - p. 265 28. Chapter 21 The role of epigenetics in cancer metastasis - p. 277 29. Chapter 22 Regulation of angiogenesis in tumor metastasis via Ets-related ERG and micro-RNAs; one hand washes the other - p. 301 30. Index - p. 317
