This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Immunology and Allergy Clinics of North America - p. 5 6. Preface - p. 6 7. Biomarkers in Asthma and Allergy - p. 7 8. Exhaled Nitric Oxide - p. 8 9. Exhaled Breath Condensate - p. 18 10. Exhaled Breath Condensate pH Assays - p. 24 11. Asthma Biomarkers in Sputum - p. 30 12. Tissue-Based and Bronchoalveolar Lavage–Based Biomarkers in Asthma - p. 38 13. Bronchoprovocation Testing in Asthma - p. 45 14. Urinary leukotriene E4 as a Biomarker of Exposure, Susceptibility and Risk in Asthma - p. 51 15. Index - p. 59
This issue of Immunology and Allergy Clinics provides a comprehensive review of the current state of biomarkers and their role in the asthma diagnostic and therapeutic algorithm.Since the last issue on Biomarkers, which published in 2007, significant research directly targeted at biomarker development and clinical trials with new biologics, using biomarkers such as exhaled nitric oxide, sputum and tissue eosinophilia as endpoints, has occurred.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Immunology and Allergy Clinics of North America - p. 5 6. Preface - p. 6 7. Biomarkers in Asthma and Allergy - p. 7 8. Exhaled Nitric Oxide - p. 8 9. Exhaled Breath Condensate - p. 18 10. Exhaled Breath Condensate pH Assays - p. 24 11. Asthma Biomarkers in Sputum - p. 30 12. Tissue-Based and Bronchoalveolar Lavage–Based Biomarkers in Asthma - p. 38 13. Bronchoprovocation Testing in Asthma - p. 45 14. Urinary leukotriene E4 as a Biomarker of Exposure, Susceptibility and Risk in Asthma - p. 51 15. Index - p. 59
