In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system. This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness.
1. Introduction - p. xxi 2. Section I: Why is the vagus getting so much attention - p. xxii 3. Chapter 1. Vagus insufficiency syndrome - p. 3 4. Chapter 2. Randomized controlled studies do not reflect the complexity of chronic disease, including the vagal response - p. 15 5. Chapter 3. Vagus nerve stimulator (VNS)—What the surgeon needs to know - p. 27 6. Chapter 4. Noninvasive vagus nerve stimulation: History, mechanisms, indications, and obstacles - p. 69 7. Exploring vagus nerve stimulation through the lens of the polyvagal theory☆ - p. 83 8. Section II: Neurologic conditions - p. 93 9. Chapter 6. Vagus nerve stimulation for the management of epilepsy - p. 97 10. Chapter 7. Noninvasive vagus nerve stimulation in migraine treatment - p. 117 11. Chapter 8. Vagal nerve stimulation in rare headache disorders - p. 127 12. Chapter 9. Vagus nerve stimulation for the management of traumatic brain injury - p. 135 13. Section III: Evolving therapy for neurologic conditions - p. 145 14. Chapter 10. Vagus nerve stimulation in acute stroke: Review based on current modalities and emerging trends - p. 149 15. Chapter 11. Using vagus nerve stimulation to direct synaptic plasticity and treat neurological disease - p. 158 16. Chapter 12. Vagus nerve stimulation for the management of tinnitus - p. 165 17. Chapter 13. Vagus nerve stimulation for the management of neurodegenerative disorders - p. 179 18. Chapter 14. Vagal nerve stimulation for cognitive and performance enhancement - p. 185 19. Chapter 15. Vagus nerve stimulation for the management of chronic pain - p. 195 20. Section IV: Psychiatric and somatic conditions - p. 202 21. Chapter 16. Vagus nerve stimulation for the management of depression and anxiety - p. 205 22. Chapter 17. Application of vagal nerve stimulation to post-traumatic stress disorder - p. 213 23. Chapter 18. Vagus nerve stimulation for the management of fibromyalgia - p. 238 24. Chapter 19. Vagus nerve stimulation for the management of visceral pain - p. 245 25. Chapter 20. Vagus nerve stimulation for the management of addiction disorders - p. 251 26. Section V: Vagus nerve stimulation and inflammation - p. 263 27. Chapter 21. Vagal nerve stimulation for the management of sepsis - p. 267 28. Chapter 22. Vagus nerve stimulation for the management of immune-mediated inflammatory diseases - p. 275 29. Chapter 23. Vagus nerve stimulation for the management of inflammatory bowel disease and the cholinergic antiinflammatory pathway - p. 289 30. Chapter 24. Clinical applications of vagal nerve stimulation for gastrointestinal motility disorders and chronic abdominal pain - p. 299 31. Chapter 25. Treatment of acute asthma exacerbations with vagus nerve stimulation - p. 307 32. Chapter 26. Metabolic syndrome: Understanding its root cause, and the role of macrophages and why vagus nerve stimulation may be an effective treatment - p. 313 33. Chapter 27. Vagus nerve stimulation for the management of obesity, type 2 diabetes mellitus, and metabolic syndrome - p. 327 34. Chapter 28. Vagus nerve stimulation and kidney function - p. 343 35. Chapter 29. The neural tourniquet - p. 351 36. Section VI: Future applications for vagus nerve stimulation - p. 362 37. Chapter 30. Vagus nerve stimulation for the treatment of heart failure - p. 365 38. Chapter 31. Vagus nerve stimulation for long COVID - p. 383 39. Chapter 32. Vagal nerve stimulation applications in oncology - p. 393 40. Index - p. 401
In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system. This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness.
1. Introduction - p. xxi 2. Section I: Why is the vagus getting so much attention - p. xxii 3. Chapter 1. Vagus insufficiency syndrome - p. 3 4. Chapter 2. Randomized controlled studies do not reflect the complexity of chronic disease, including the vagal response - p. 15 5. Chapter 3. Vagus nerve stimulator (VNS)—What the surgeon needs to know - p. 27 6. Chapter 4. Noninvasive vagus nerve stimulation: History, mechanisms, indications, and obstacles - p. 69 7. Exploring vagus nerve stimulation through the lens of the polyvagal theory☆ - p. 83 8. Section II: Neurologic conditions - p. 93 9. Chapter 6. Vagus nerve stimulation for the management of epilepsy - p. 97 10. Chapter 7. Noninvasive vagus nerve stimulation in migraine treatment - p. 117 11. Chapter 8. Vagal nerve stimulation in rare headache disorders - p. 127 12. Chapter 9. Vagus nerve stimulation for the management of traumatic brain injury - p. 135 13. Section III: Evolving therapy for neurologic conditions - p. 145 14. Chapter 10. Vagus nerve stimulation in acute stroke: Review based on current modalities and emerging trends - p. 149 15. Chapter 11. Using vagus nerve stimulation to direct synaptic plasticity and treat neurological disease - p. 158 16. Chapter 12. Vagus nerve stimulation for the management of tinnitus - p. 165 17. Chapter 13. Vagus nerve stimulation for the management of neurodegenerative disorders - p. 179 18. Chapter 14. Vagal nerve stimulation for cognitive and performance enhancement - p. 185 19. Chapter 15. Vagus nerve stimulation for the management of chronic pain - p. 195 20. Section IV: Psychiatric and somatic conditions - p. 202 21. Chapter 16. Vagus nerve stimulation for the management of depression and anxiety - p. 205 22. Chapter 17. Application of vagal nerve stimulation to post-traumatic stress disorder - p. 213 23. Chapter 18. Vagus nerve stimulation for the management of fibromyalgia - p. 238 24. Chapter 19. Vagus nerve stimulation for the management of visceral pain - p. 245 25. Chapter 20. Vagus nerve stimulation for the management of addiction disorders - p. 251 26. Section V: Vagus nerve stimulation and inflammation - p. 263 27. Chapter 21. Vagal nerve stimulation for the management of sepsis - p. 267 28. Chapter 22. Vagus nerve stimulation for the management of immune-mediated inflammatory diseases - p. 275 29. Chapter 23. Vagus nerve stimulation for the management of inflammatory bowel disease and the cholinergic antiinflammatory pathway - p. 289 30. Chapter 24. Clinical applications of vagal nerve stimulation for gastrointestinal motility disorders and chronic abdominal pain - p. 299 31. Chapter 25. Treatment of acute asthma exacerbations with vagus nerve stimulation - p. 307 32. Chapter 26. Metabolic syndrome: Understanding its root cause, and the role of macrophages and why vagus nerve stimulation may be an effective treatment - p. 313 33. Chapter 27. Vagus nerve stimulation for the management of obesity, type 2 diabetes mellitus, and metabolic syndrome - p. 327 34. Chapter 28. Vagus nerve stimulation and kidney function - p. 343 35. Chapter 29. The neural tourniquet - p. 351 36. Section VI: Future applications for vagus nerve stimulation - p. 362 37. Chapter 30. Vagus nerve stimulation for the treatment of heart failure - p. 365 38. Chapter 31. Vagus nerve stimulation for long COVID - p. 383 39. Chapter 32. Vagal nerve stimulation applications in oncology - p. 393 40. Index - p. 401
