Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.
The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.
1. Cover image - p. c 2. Series Page - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contents - p. vii 7. Contributors - p. xi 8. Preface - p. xiii 9. 1. Phylogenetic relationship of vertebrate carbonic anhydrases - p. 1 10. 2. Carbonic anhydrases I and II - p. 29 11. 3. Carbonic anhydrase III - p. 69 12. 4. Carbonic anhydrases IV and XV - p. 85 13. 5. Mitochondrial carbonic anhydrases VA and VB: Metabolic roles and clinical significance - p. 105 14. 6. Carbonic anhydrase VI - p. 131 15. 7. Carbonic anhydrase VII: Development of selective inhibitors and their pharmacological significance - p. 155 16. 8. Carbonic anhydrase-related proteins VIII, X, and XI: Evolutionary divergence and emerging biological roles - p. 177 17. 9. Carbonic anhydrase IX and XII - p. 195 18. 10. Carbonic anhydrase XIII - p. 243 19. 11. Carbonic anhydrase XIV - p. 271 20. 12. Challenges and opportunities for developing selective carbonic anhydrase inhibitors and activators for vertebrate isoforms - p. 299
Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.
The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.
1. Cover image - p. c 2. Series Page - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contents - p. vii 7. Contributors - p. xi 8. Preface - p. xiii 9. 1. Phylogenetic relationship of vertebrate carbonic anhydrases - p. 1 10. 2. Carbonic anhydrases I and II - p. 29 11. 3. Carbonic anhydrase III - p. 69 12. 4. Carbonic anhydrases IV and XV - p. 85 13. 5. Mitochondrial carbonic anhydrases VA and VB: Metabolic roles and clinical significance - p. 105 14. 6. Carbonic anhydrase VI - p. 131 15. 7. Carbonic anhydrase VII: Development of selective inhibitors and their pharmacological significance - p. 155 16. 8. Carbonic anhydrase-related proteins VIII, X, and XI: Evolutionary divergence and emerging biological roles - p. 177 17. 9. Carbonic anhydrase IX and XII - p. 195 18. 10. Carbonic anhydrase XIII - p. 243 19. 11. Carbonic anhydrase XIV - p. 271 20. 12. Challenges and opportunities for developing selective carbonic anhydrase inhibitors and activators for vertebrate isoforms - p. 299
