Viral Hemorrhagic Fevers: Epidemiology, Pathogenesis, Management, and Preparedness covers the causative agents, outbreaks, and clinical management of emerging and re-emerging viral hemorrhagic fevers. Coverage includes a range of topics from basic virology, epidemiology, and disease pathogenesis of emerging and re-emerging hemorrhagic fever viruses. The book examines host-virus interactions, immune pathogenesis, and recent trends in disease diagnostics. It also covers current state-of-the-art in understanding molecular mechanisms of disease pathogenesis, the potential of molecular markers for disease prognostics, early prediction of disease outcome, advancements in diagnosis and drug development, and strategies in pandemic preparation, mitigation, and responses in public health security.
With chapters written and compiled by a team of well-known virologists, clinicians as well as regulatory and public health experts. This book is a comprehensive guide that will help users understand the transmission, pathogenesis, and clinical management of emerging and re-emerging viruses causing hemorrhagic diseases.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xvii 7. Foreword 1 - p. xxiii 8. Foreword 2 - p. xxv 9. Chapter 1. VHF: Diversity of viruses and animal vectors involved in disease transmission - p. 1 10. Chapter 2. Emerging and re-emerging hemorrhagic fever causing viruses in recent years - p. 23 11. Chapter 3. Viral hemorrhagic fever: clinical symptoms and syndromes - p. 45 12. Chapter 4. Advances in the laboratory diagnostics - p. 53 13. Chapter 5. Critical care management of viral hemorrhagic fever - p. 65 14. Chapter 6. Neurological manifestation and neuropathogenesis in VHF - p. 89 15. Chapter 7. Molecular markers for the early prediction of disease outcome - p. 115 16. Chapter 8. Animal models for hemorrhagic fevers - p. 157 17. Chapter 9. Applications of omics in the disease pathogenesis - p. 181 18. Chapter 10. Molecular pathogenesis—Part A - p. 213 19. 1 Crimean-Congo hemorrhagic fever virus - p. 214 20. 2 Rift Valley Fever Virus - p. 219 21. 3 Nipah virus - p. 226 22. 4 Hantavirus - p. 234 23. 5 Dengue virus - p. 239 24. Funding - p. 245 25. Chapter 11. Molecular pathogenesis—Part B - p. 273 26. Chapter 12. Vaccine for viral hemorrhagic fever — updates and challenges - p. 301 27. Chapter 13. Current antivirals and future directions in drug discovery for filovirus infections - p. 317 28. Chapter 14. Viral hemorrhagic fever (VHF): Biothreat scenarios, bioweapon potential, and counterterrorism - p. 339 29. Chapter 15. Overview of viral hemorraghic fever prevention and preparedness - p. 368 30. Chapter 16. Outbreaks preparedness and public health management - p. 399 31. Index - p. 411
Viral Hemorrhagic Fevers: Epidemiology, Pathogenesis, Management, and Preparedness covers the causative agents, outbreaks, and clinical management of emerging and re-emerging viral hemorrhagic fevers. Coverage includes a range of topics from basic virology, epidemiology, and disease pathogenesis of emerging and re-emerging hemorrhagic fever viruses. The book examines host-virus interactions, immune pathogenesis, and recent trends in disease diagnostics. It also covers current state-of-the-art in understanding molecular mechanisms of disease pathogenesis, the potential of molecular markers for disease prognostics, early prediction of disease outcome, advancements in diagnosis and drug development, and strategies in pandemic preparation, mitigation, and responses in public health security.
With chapters written and compiled by a team of well-known virologists, clinicians as well as regulatory and public health experts. This book is a comprehensive guide that will help users understand the transmission, pathogenesis, and clinical management of emerging and re-emerging viruses causing hemorrhagic diseases.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xvii 7. Foreword 1 - p. xxiii 8. Foreword 2 - p. xxv 9. Chapter 1. VHF: Diversity of viruses and animal vectors involved in disease transmission - p. 1 10. Chapter 2. Emerging and re-emerging hemorrhagic fever causing viruses in recent years - p. 23 11. Chapter 3. Viral hemorrhagic fever: clinical symptoms and syndromes - p. 45 12. Chapter 4. Advances in the laboratory diagnostics - p. 53 13. Chapter 5. Critical care management of viral hemorrhagic fever - p. 65 14. Chapter 6. Neurological manifestation and neuropathogenesis in VHF - p. 89 15. Chapter 7. Molecular markers for the early prediction of disease outcome - p. 115 16. Chapter 8. Animal models for hemorrhagic fevers - p. 157 17. Chapter 9. Applications of omics in the disease pathogenesis - p. 181 18. Chapter 10. Molecular pathogenesis—Part A - p. 213 19. 1 Crimean-Congo hemorrhagic fever virus - p. 214 20. 2 Rift Valley Fever Virus - p. 219 21. 3 Nipah virus - p. 226 22. 4 Hantavirus - p. 234 23. 5 Dengue virus - p. 239 24. Funding - p. 245 25. Chapter 11. Molecular pathogenesis—Part B - p. 273 26. Chapter 12. Vaccine for viral hemorrhagic fever — updates and challenges - p. 301 27. Chapter 13. Current antivirals and future directions in drug discovery for filovirus infections - p. 317 28. Chapter 14. Viral hemorrhagic fever (VHF): Biothreat scenarios, bioweapon potential, and counterterrorism - p. 339 29. Chapter 15. Overview of viral hemorraghic fever prevention and preparedness - p. 368 30. Chapter 16. Outbreaks preparedness and public health management - p. 399 31. Index - p. 411
