Viral Proteases, Volume 58 in The Enzymes series, presents a comprehensive overview of recent advances in the structural and functional understanding of viral proteases and their potential as drug targets. This new volume includes chapters covering a wide range of topics, including Viral proteases as targets for antiviral drugs, Structural biology of viral proteases, Computational approaches for designing viral protease inhibitors, The peptidomimetic approach for the design of viral protease inhibitors, HIV protease and its inhibition, and much more.
Additional sections cover Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies, Coronaviruses main proteases and their inhibitors, Coronaviruses papain-like proteases, Flaviviruses proteases (Zika, West Nile, Dengue), Bacteriophage endolysins, and Challenges for developing selective viral protease inhibitors as anti-infectives.
1. Cover image - p. i 2. Viral Proteases - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Contents - p. v 6. Contributors - p. ix 7. Preface - p. xi 8. 1 Viral proteases as targets for antivirals drugs - p. 1 9. 2 Viral proteases: Structural basis of function, evolution, and drug design - p. 19 10. 3 Computational approaches for designing viral protease inhibitors - p. 59 11. 4 The peptidomimetic approach for the design of viral protease inhibitors - p. 93 12. 5 HIV protease and its inhibition - p. 129 13. 6 Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies - p. 151 14. 7 Coronaviruses main proteases and their inhibitors - p. 183 15. 8 Coronaviruses papain-like proteases and their inhibitors - p. 209 16. 9 Flaviviruses proteases - p. 251 17. 10 Bacteriophage endolysins - p. 279 18. 11 Challenges for developing selective viral protease inhibitors as antiinfectives - p. 319
Viral Proteases, Volume 58 in The Enzymes series, presents a comprehensive overview of recent advances in the structural and functional understanding of viral proteases and their potential as drug targets. This new volume includes chapters covering a wide range of topics, including Viral proteases as targets for antiviral drugs, Structural biology of viral proteases, Computational approaches for designing viral protease inhibitors, The peptidomimetic approach for the design of viral protease inhibitors, HIV protease and its inhibition, and much more.
Additional sections cover Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies, Coronaviruses main proteases and their inhibitors, Coronaviruses papain-like proteases, Flaviviruses proteases (Zika, West Nile, Dengue), Bacteriophage endolysins, and Challenges for developing selective viral protease inhibitors as anti-infectives.
1. Cover image - p. i 2. Viral Proteases - p. ii 3. Title page - p. iii 4. Copyright - p. iv 5. Contents - p. v 6. Contributors - p. ix 7. Preface - p. xi 8. 1 Viral proteases as targets for antivirals drugs - p. 1 9. 2 Viral proteases: Structural basis of function, evolution, and drug design - p. 19 10. 3 Computational approaches for designing viral protease inhibitors - p. 59 11. 4 The peptidomimetic approach for the design of viral protease inhibitors - p. 93 12. 5 HIV protease and its inhibition - p. 129 13. 6 Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies - p. 151 14. 7 Coronaviruses main proteases and their inhibitors - p. 183 15. 8 Coronaviruses papain-like proteases and their inhibitors - p. 209 16. 9 Flaviviruses proteases - p. 251 17. 10 Bacteriophage endolysins - p. 279 18. 11 Challenges for developing selective viral protease inhibitors as antiinfectives - p. 319
