Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Series Page - p. iii 5. Copyright - p. iii 6. Contributors - p. iii 7. Preface - p. xiii 8. Chapter One: CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis - p. 1 9. Chapter Two: Mechanisms of inhibition of viral RNA replication by nucleotide analogs - p. 39 10. Chapter Three: HCV RdRp, sofosbuvir and beyond - p. 63 11. Chapter Four: Understanding viral replication and transcription using single-molecule techniques - p. 83 12. Chapter Five: In vitro single-molecule manipulation studies of viral DNA replication - p. 115 13. Chapter Six: Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity - p. 149 14. Chapter Seven: Single-cell analysis for the study of viral inhibitors - p. 195 15. Chapter Eight: Structural basis of viral RNA-dependent RNA polymerase nucleotide addition cycle in picornaviruses - p. 215 16. Chapter Nine: Picornaviral 2C proteins: A unique ATPase family critical in virus replication - p. 235 17. Chapter Ten: Flavivirus enzymes and their inhibitors - p. 265 18. Chapter Eleven: Watching the bacterial RNA polymerase transcription reaction by time-dependent soak-trigger-freeze X-ray crystallography - p. 305 19. Chapter Twelve: Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs - p. 315
Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Series Page - p. iii 5. Copyright - p. iii 6. Contributors - p. iii 7. Preface - p. xiii 8. Chapter One: CoV-er all the bases: Structural perspectives of SARS-CoV-2 RNA synthesis - p. 1 9. Chapter Two: Mechanisms of inhibition of viral RNA replication by nucleotide analogs - p. 39 10. Chapter Three: HCV RdRp, sofosbuvir and beyond - p. 63 11. Chapter Four: Understanding viral replication and transcription using single-molecule techniques - p. 83 12. Chapter Five: In vitro single-molecule manipulation studies of viral DNA replication - p. 115 13. Chapter Six: Allosteric and dynamic control of RNA-dependent RNA polymerase function and fidelity - p. 149 14. Chapter Seven: Single-cell analysis for the study of viral inhibitors - p. 195 15. Chapter Eight: Structural basis of viral RNA-dependent RNA polymerase nucleotide addition cycle in picornaviruses - p. 215 16. Chapter Nine: Picornaviral 2C proteins: A unique ATPase family critical in virus replication - p. 235 17. Chapter Ten: Flavivirus enzymes and their inhibitors - p. 265 18. Chapter Eleven: Watching the bacterial RNA polymerase transcription reaction by time-dependent soak-trigger-freeze X-ray crystallography - p. 305 19. Chapter Twelve: Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs - p. 315
