Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.
The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.
1. Chapter 1. Introduction to virus origins and their role in biological evolution - p. 1 2. Chapter 2. Molecular basis of genetic variation of viruses: error-prone replication - p. 35 3. Chapter 3. Darwinian principles acting on highly mutable viruses - p. 73 4. Chapter 4. Interaction of virus populations with their hosts - p. 123 5. Chapter 5. Viral fitness as a measure of adaptation - p. 167 6. Chapter 6. Virus population dynamics examined with experimental model systems - p. 195 7. Chapter 7. Long-term virus evolution in nature - p. 225 8. Chapter 8. Quasispecies dynamics in disease prevention and control - p. 263 9. Chapter 9. Trends in antiviral strategies - p. 301 10. Chapter 10. Collective population effects in nonviral systems - p. 341 11. Subject Index - p. 367 12. Author Index - p. 379
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.
The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.
1. Chapter 1. Introduction to virus origins and their role in biological evolution - p. 1 2. Chapter 2. Molecular basis of genetic variation of viruses: error-prone replication - p. 35 3. Chapter 3. Darwinian principles acting on highly mutable viruses - p. 73 4. Chapter 4. Interaction of virus populations with their hosts - p. 123 5. Chapter 5. Viral fitness as a measure of adaptation - p. 167 6. Chapter 6. Virus population dynamics examined with experimental model systems - p. 195 7. Chapter 7. Long-term virus evolution in nature - p. 225 8. Chapter 8. Quasispecies dynamics in disease prevention and control - p. 263 9. Chapter 9. Trends in antiviral strategies - p. 301 10. Chapter 10. Collective population effects in nonviral systems - p. 341 11. Subject Index - p. 367 12. Author Index - p. 379
