Year Book of Neonatal and Perinatal Medicine 2014

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. The Fetus - p. 8 5. Conservative management of antenatally diagnosed cystic lung malformations - p. 9 6. Absent Fetal Nasal Bone: What Does it Mean for the Euploid Fetus? - p. 10 7. Epidemiology and Pregnancy Complications - p. 11 8. The Effect of Real-Time Continuous Glucose Monitoring in Pregnant Women With Diabetes: A randomized controlled trial - p. 12 9. Impact of ART on pregnancies in California: an analysis of maternity outcomes and insights into the added burden of neonatal intensive care - p. 13 10. Amnioinfusion in very early preterm prelabor rupture of membranes (AMIPROM): pregnancy, neonatal and maternal outcomes in a randomized controlled pilot study - p. 14 11. EXPRESS study shows significant regional differences in 1-year outcome of extremely preterm infants in Sweden - p. 15 12. Outcomes of Infants Born at 22 and 23 Weeks' Gestation - p. 16 13. Antecedents of Cerebral Palsy and Perinatal Death in Term and Late Preterm Singletons - p. 17 14. Claims for compensation after alleged birth asphyxia: a nationwide study covering 15 years - p. 18 15. Assisted reproductive technologies impair the expression and methylation of insulin-induced gene 1 and sterol regulatory element-binding factor 1 in the fetus and placenta - p. 19 16. Genetics and Teratology - p. 20 17. DNA Sequencing versus Standard Prenatal Aneuploidy Screening - p. 21 18. Minor Anomalies: Can They Predict Specific Major Defects? A Study Based on 23 Major and 14 Minor Anomalies in Over 25,000 Newborns with Birth Defects - p. 22 19. Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age - p. 23 20. Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy - p. 24 21. Neonatal Genome-Wide Methylation Patterns in Relation to Birth Weight in the Norwegian Mother and Child Cohort - p. 25 22. Additional value of prenatal genomic array testing in fetuses with isolated structural ultrasound abnormalities and a normal karyotype: a systematic review of the literature - p. 26 23. Anomalies associated with gastroschisis and omphalocele: Analysis of 2825 cases from the Texas Birth Defects Registry - p. 27 24. Accuracy of Ultrasonography at 11–14 Weeks of Gestation for Detection of Fetal Structural Anomalies: A Systematic Review - p. 28 25. Labor and Delivery - p. 29 26. Triggers of Spontaneous Preterm Delivery – Why Today? - p. 30 27. Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (ASTECS trial) - p. 31 28. The effect of obstetric practice change to reduce early term delivery on perinatal outcome - p. 32 29. Immersion in Water During Labor and Delivery - p. 33 30. Effect of Delayed vs Early Umbilical Cord Clamping on Iron Status and Neurodevelopment at Age 12 Months: A Randomized Clinical Trial - p. 34 31. The effects of umbilical cord milking in extremely preterm infants: a randomized controlled trial - p. 35 32. Rapid target allopurinol concentrations in the hypoxic fetus after maternal administration during labour - p. 36 33. Vaginal delivery versus caesarean section in preterm breech delivery: a systematic review - p. 37 34. Resuscitation intensity at birth is associated with changes in brain metabolic development in preterm neonates - p. 38 35. Terminal Fetal Heart Decelerations and Neonatal Outcomes - p. 39 36. Delay in intervention increases neonatal morbidity in births monitored with cardiotocography and ST-waveform analysis - p. 40 37. The impact of introducing universal umbilical cord blood gas analysis and lactate measurement at delivery - p. 41 38. Training Neonatal Cardiopulmonary Resuscitation: Can It Be Improved by Playing a Musical Prompt? A Pilot Study - p. 42 39. Improving Delivery Room Management for Very Preterm Infants - p. 43 40. Perinatal outcomes for extremely preterm babies in relation to place of birth in England: the EPICure 2 study - p. 44 41. Selected perinatal outcomes associated with planned home births in the United States - p. 45 42. Infectious Disease and Immunology - p. 46 43. Stratification of Risk of Early-Onset Sepsis in Newborns ≥34 Weeks' Gestation - p. 47 44. Effect of Fluconazole Prophylaxis on Candidiasis and Mortality in Premature Infants: A Randomized Clinical Trial - p. 48 45. Using vaginal Group B Streptococcus colonisation in women with preterm premature rupture of membranes to guide the decision for immediate delivery: a secondary analysis of the PPROMEXIL trials - p. 49 46. Maternal Antibody at Delivery Protects Neonates From Early Onset Group B Streptococcal Disease - p. 50 47. Impact of Perinatal Practices for Early-onset Group B Streptococcal Disease Prevention - p. 51 48. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice - p. 52 49. Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial - p. 53 50. Toll-like receptor genetic variants are associated with gram-negative infections in VLBW infants - p. 54 51. Neutrophil CD64 for Daily Surveillance of Systemic Infection and Necrotizing Enterocolitis in Preterm Infants - p. 55 52. Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis - p. 56 53. Cardiovascular System - p. 57 54. A randomised placebo-controlled trial of early treatment of the patent ductus arteriosus - p. 58 55. Comparison of Oral Paracetamol versus Ibuprofen in Premature Infants with Patent Ductus Arteriosus: A Randomized Controlled Trial - p. 59 56. Oral Paracetamol versus Oral Ibuprofen in the Management of Patent Ductus Arteriosus in Preterm Infants: A Randomized Controlled Trial - p. 60 57. Hypotension in Preterm Neonates: Low Blood Pressure Alone Does Not Affect Neurodevelopmental Outcome - p. 61 58. Use of Antihypotensive Therapies in Extremely Preterm Infants - p. 62 59. Targeted neonatal echocardiography (TnECHO) service in a Canadian neonatal intensive care unit: a 4-year experience - p. 63 60. Pulse oximetry screening for critical congenital heart defects in newborn infants: Should it be routine? - p. 64 61. Late Detection of Critical Congenital Heart Disease Among US Infants: Estimation of the Potential Impact of Proposed Universal Screening Using Pulse Oximetry - p. 65 62. Cardiovascular function in children who had chronic lung disease of prematurity - p. 66 63. Unilateral Vocal Fold Paralysis After Congenital Cardiothoracic Surgery: A Meta-analysis - p. 67 64. Respiratory Disorders - p. 68 65. Effects of Targeting Higher vs Lower Arterial Oxygen Saturations on Death or Disability in Extremely Preterm Infants: A Randomized Clinical Trial - p. 69 66. Respiratory Outcomes of the Surfactant Positive Pressure and Oximetry Randomized Trial (SUPPORT) - p. 70 67. Oxygen Saturation and Outcomes in Preterm Infants - p. 71 68. Oxygen Saturation and Outcomes in Preterm Infants - p. 72 69. Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit - p. 73 70. Transcribed oxygen saturation vs oximeter recordings in very low birth weight infants - p. 74 71. Reducing Unplanned Extubations in the NICU - p. 75 72. Comparative effectiveness of surfactant preparations in premature infants - p. 76 73. Surfactant Deficiency in Infants with Severe Acute Viral Bronchiolitis - p. 77 74. A Randomized Controlled Trial of Two Nasal Continuous Positive Airway Pressure Levels after Extubation in Preterm Infants - p. 78 75. Heliox for mechanically ventilated newborns with bronchopulmonary dysplasia - p. 79 76. Impact of early surfactant and inhaled nitric oxide therapies on outcomes in term/late preterm neonates with moderate hypoxic respiratory failure - p. 80 77. Tracheomegaly in Infants with Severe Congenital Diaphragmatic Hernia Treated with Fetal Endoluminal Tracheal Occlusion - p. 81 78. Extracorporeal Life Support in Patients with Congenital Diaphragmatic Hernia: How Long Should We Treat? - p. 82 79. Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia - p. 83 80. Variation in the Use of Diuretic Therapy for Infants With Bronchopulmonary Dysplasia - p. 84 81. Death or Neurodevelopmental Impairment at 18 to 22 Months Corrected Age in a Randomized Trial of Early Dexamethasone to Prevent Death or Chronic Lung Disease in Extremely Low Birth Weight Infants - p. 85 82. Association between Postnatal Dexamethasone for Treatment of Bronchopulmonary Dysplasia and Brain Volumes at Adolescence in Infants Born Very Preterm - p. 86 83. Mesenchymal Stem Cells for Bronchopulmonary Dysplasia: Phase 1 Dose-Escalation Clinical Trial - p. 87 84. Late Outcomes of a Randomized Trial of High-Frequency Oscillation in Neonates - p. 88 85. Accurate Automated Apnea Analysis in Preterm Infants - p. 89 86. Application of Transcutaneous Carbon Dioxide Tension Monitoring with Low Electrode Temperatures in Premature Infants in the Early Postnatal Period - p. 90 87. Test–retest reliability of the infant car-seat challenge - p. 91 88. Two-Year Outcomes of a Randomized Controlled Trial of Inhaled Nitric Oxide in Premature Infants - p. 92 89. Central Nervous System and Special Senses - p. 93 90. Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extreme Preterm Infants - p. 94 91. Risk Factors for Intraventricular Hemorrhage in Term Asphyxiated Newborns Treated With Hypothermia - p. 95 92. Can neurophysiological assessment improve timing of intervention in posthaemorrhagic ventricular dilatation? - p. 96 93. Cerebral desaturations in preterm infants: a crossover trial on influence of oxygen saturation target range - p. 97 94. Neuroimaging in the Evaluation of Neonatal Encephalopathy - p. 98 95. Neuroimaging in the Evaluation of Neonatal Encephalopathy - p. 99 96. Xenon Ventilation During Therapeutic Hypothermia in Neonatal Encephalopathy: A Feasibility Study - p. 100 97. Predictive value of the amplitude integrated EEG in infants with hypoxic ischaemic encephalopathy: data from a randomised trial of therapeutic hypothermia - p. 101 98. Acute neonatal encephalopathy and seizures recurrence: A combined aEEG/EEG study - p. 102 99. Factors Associated with Permanent Hearing Impairment in Infants Treated with Therapeutic Hypothermia - p. 103 100. Anticonvulsant effect of xenon on neonatal asphyxial seizures - p. 104 101. Moderate and Late Preterm Birth: Effect on Brain Size and Maturation at Term-Equivalent Age - p. 105 102. Association between Postnatal Dexamethasone for Treatment of Bronchopulmonary Dysplasia and Brain Volumes at Adolescence in Infants Born Very Preterm - p. 106 103. Association between Postnatal Dexamethasone for Treatment of Bronchopulmonary Dysplasia and Brain Volumes at Adolescence in Infants Born Very Preterm - p. 107 104. Human milk feeding prevents retinopathy of prematurity (ROP) in preterm VLBW neonates - p. 108 105. Ophthalmologic Outcome at 30 Months' Corrected Age of a Prospective Swedish Cohort of Children Born Before 27 Weeks of Gestation: The Extremely Preterm Infants in Sweden Study - p. 109 106. Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options - p. 110 107. Alterations in Brain Structure and Neurodevelopmental Outcome in Preterm Infants Hospitalized in Different Neonatal Intensive Care Unit Environments - p. 111 108. Gastrointestinal Health and Nutrition - p. 112 109. Gut microbiota in preterm infants: assessment and relevance to health and disease - p. 113 110. Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation - p. 114 111. Three Main Factors Define Changes in Fecal Microbiota Associated With Feeding Modality in Infants - p. 115 112. Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+ cells through TLR4 - p. 116 113. Effects of Different Complementary Feeding Regimens on Iron Status and Enteric Microbiota in Breastfed Infants - p. 117 114. Fecal S100A12: Identifying Intestinal Distress in Very-Low-Birth-Weight Infants - p. 118 115. Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression - p. 119 116. Epigenetic Effects of Human Breast Milk - p. 120 117. A Pacifier-Activated Music Player With Mother's Voice Improves Oral Feeding in Preterm Infants - p. 121 118. A Pacifier-Activated Music Player With Mother's Voice Improves Oral Feeding in Preterm Infants - p. 122 119. Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants - p. 123 120. Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants - p. 124 121. Effect of Fortifiers and Additional Protein on the Osmolarity of Human Milk: Is It Still Safe for the Premature Infant? - p. 125 122. Variability in human milk composition: benefit of individualized fortification in very-low-birth-weight infants - p. 126 123. A standardized nutrition approach for very low birth weight neonates improves outcomes, reduces cost and is not associated with increased rates of necrotizing enterocolitis, sepsis or mortality - p. 127 124. Cohort Study of Probiotics in a North American Neonatal Intensive Care Unit - p. 128 125. Randomized controlled trial of prophylactic rectal stimulation and enemas on stooling patterns in extremely low birth weight infants - p. 129 126. Epidemiology and Trends of Necrotizing Enterocolitis in Sweden: 1987–2009 - p. 130 127. Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis - p. 131 128. Association of cord blood digitalis-like factor and necrotizing enterocolitis - p. 132 129. Brain Magnetic Resonance Imaging in Infants with Surgical Necrotizing Enterocolitis or Spontaneous Intestinal Perforation versus Medical Necrotizing Enterocolitis - p. 133 130. Intestinal location of necrotizing enterocolitis among infants with congenital heart disease - p. 134 131. Cronobacter: an emerging opportunistic pathogen associated with neonatal meningitis, sepsis and necrotizing enterocolitis - p. 135 132. Usefulness of abdominal ultrasound in diagnosing necrotising enterocolitis - p. 136 133. A prospective comparison of intestinal sonography and abdominal radiographs in a neonatal intensive care unit - p. 137 134. Interleukin-8 predicts 60-day mortality in premature infants with necrotizing enterocolitis - p. 138 135. Cytokine Levels in the Preterm Infant with Neonatal Intestinal Injury - p. 139 136. Randomized Controlled Trial of Slow vs Rapid Enteral Feeding Advancements on the Clinical Outcomes of Preterm Infants With Birth Weight 750–1250 g - p. 140 137. Enteral L-Arginine Supplementation for Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Neonates: A Double-Blind Randomized Pilot Study of Efficacy and Safety - p. 141 138. Growth and Fatty Acid Profiles of VLBW Infants Receiving a Multicomponent Lipid Emulsion From Birth - p. 142 139. Safety and Efficacy of Early Parenteral Lipid and High-Dose Amino Acid Administration to Very Low Birth Weight Infants - p. 143 140. Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay - p. 144 141. Hematology and Bilirubin - p. 145 142. A Randomized, Masked, Placebo-Controlled Study of Darbepoetin Alfa in Preterm Infants - p. 146 143. Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo - p. 147 144. Association, among very-low-birthweight neonates, between red blood cell transfusions in the week after birth and severe intraventricular hemorrhage - p. 148 145. The effect of hematocrit on the efficacy of phototherapy for neonatal jaundice - p. 149 146. Causes of hemolysis in neonates with extreme hyperbilirubinemia - p. 150 147. Unbound Free Fatty Acids from Preterm Infants Treated with Intralipid Decouples Unbound from Total Bilirubin Potentially Making Phototherapy Ineffective - p. 151 148. Bilistick: A Low-Cost Point-of-Care System to Measure Total Plasma Bilirubin - p. 152 149. Predischarge Screening for Severe Neonatal Hyperbilirubinemia Identifies Infants Who Need Phototherapy - p. 153 150. Severe Neonatal Hyperbilirubinemia in the Netherlands - p. 154 151. Iron supplementation in premature infants using the zinc protoporphyrin to heme ratio: short- and long-term outcomes - p. 155 152. Renal, Metabolism and Endocrine Disorders - p. 156 153. Neonatal Thyrotoxicosis - p. 157 154. Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study): a randomised, double-blind, placebo-controlled trial - p. 158 155. Early Hyperglycemia Is Associated With Poor Gross Motor Outcome in Asphyxiated Term Newborns - p. 159 156. ACTH and cortisol cord plasma concentrations in preterm and term infants - p. 160 157. Miscellaneous - p. 161 158. Randomized controlled trial of Family Nurture Intervention in the NICU: assessments of length of stay, feasibility and safety - p. 162 159. Online support for parents of preterm infants: a qualitative and content analysis of Facebook ‘preemie’ groups - p. 163 160. Neonatal intensive care unit handoffs: a pilot study on core elements and epidemiology of errors - p. 164 161. Examining the effects of a targeted noise reduction program in a neonatal intensive care unit - p. 165 162. Breastfeeding Keratosis: This Frictional Keratosis of Newborns May Mimic Thrush - p. 166 163. Prediction of Neonatal Outcomes in Extremely Preterm Neonates - p. 167 164. Utility of delayed surgical repair of neonatal brachial plexus palsy - p. 168 165. A comparison of the infant car seat challenge and the polysomnogram at the time of hospital discharge - p. 169 166. Increased Enamel Hypoplasia and Very Low Birthweight Infants - p. 170 167. Compliance with the Baby-Friendly Hospital Initiative and impact on breastfeeding rates - p. 171 168. Deaths and near deaths of healthy newborn infants while bed sharing on maternity wards - p. 172 169. Pharmacology - p. 173 170. Effect of Fluconazole Prophylaxis on Candidiasis and Mortality in Premature Infants: A Randomized Clinical Trial - p. 174 171. Prophylactic Indomethacin Worsens Short-Term Respiratory Outcomes in Extremely Low-Birth-Weight Infants - p. 175 172. Characterization of the Population Pharmacokinetics of Ampicillin in Neonates Using an Opportunistic Study Design - p. 176 173. Accuracy of the concentration of morphine infusions prepared for patients in a neonatal intensive care unit - p. 177 174. Unlicensed and off-label drug use in an Irish neonatal intensive care unit: a prospective cohort study - p. 178 175. Transplacental passage of vancomycin from mother to neonate - p. 179 176. Postnatal Growth and Development/Follow-up - p. 180 177. Alterations in Brain Structure and Neurodevelopmental Outcome in Preterm Infants Hospitalized in Different Neonatal Intensive Care Unit Environments - p. 181 178. Comparison of Bayley-2 and Bayley-3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia - p. 182 179. Performance of the Parent Report of Children's Abilities–Revised (PARCA-R) versus the Bayley Scales of Infant Development III - p. 183 180. Effect of primary language on developmental testing in children born extremely preterm - p. 184 181. Predictive value of the amplitude integrated EEG in infants with hypoxic ischaemic encephalopathy: data from a randomised trial of therapeutic hypothermia - p. 185 182. Antenatal steroid exposure and outcomes of very premature infants: a regional cohort study - p. 186 183. Characteristics of extremely low-birth-weight infant survivors with unimpaired outcomes at 30 months of age - p. 187 184. Two-Year Outcomes of a Randomized Controlled Trial of Inhaled Nitric Oxide in Premature Infants - p. 188 185. Need for Supplemental Oxygen at Discharge in Infants with Bronchopulmonary Dysplasia Is Not Associated with Worse Neurodevelopmental Outcomes at 3 Years Corrected Age - p. 189 186. Neurodevelopmental outcomes of extremely low birth weight infants with spontaneous intestinal perforation or surgical necrotizing enterocolitis - p. 190 187. Neonatal ECMO study of temperature (NEST): a randomized controlled trial - p. 191 188. Late Outcomes of a Randomized Trial of High-Frequency Oscillation in Neonates - p. 192 189. Long-term cognitive and neurological outcome of preterm infants with postnatally acquired CMV infection through breast milk - p. 193 190. Neurodevelopmental outcome, psychological adjustment, and quality of life in adolescents with congenital heart disease - p. 194 191. Tracheostomy for Infants Requiring Prolonged Mechanical Ventilation: 10 Years' Experience - p. 195 192. Postnatal corticosteroids and neurodevelopmental outcomes in extremely low birthweight or extremely preterm infants: 15-year experience in Victoria, Australia - p. 196 193. Motor skills at 23 years of age in young adults born preterm with very low birth weight - p. 197 194. Ethics - p. 198 195. 23andMe and the FDA - p. 199 196. Views of parents and health-care providers regarding parental presence at bedside rounds in a neonatal intensive care unit - p. 200 197. Medical interventions for children with trisomy 13 and trisomy 18: what is the value of a short disabled life? - p. 201 198. End-of-life care in Toronto neonatal intensive care units: challenges for physician trainees - p. 202 199. Lack of physician-patient communication as a key factor associated with malpractice litigation in neonatal brachial plexus palsy - p. 203 200. Facing Persistent Challenges in Pediatric Decision-Making: New Hastings Center Guidelines - p. 204 201. Is Treatment Futile for an Extremely Premature Infant With Giant Omphalocele? - p. 205 202. Ethical and legal aspects of noninvasive prenatal genetic diagnosis - p. 206