The Year Book of Pediatrics brings you abstracts of the articles that reported the year's breakthrough developments in pediatrics, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! This annual covers all aspects of pediatric care from infectious diseases and immunology, adolescent medicine, therapeutics and toxicology, child development, dentistry and otolaryngology and neurology and psychiatry. The Year Book of Pediatrics publishes annually in December of the preceding year.
1. Cover - p. 1 2. Contents - p. 2 3. US Adolescent Nutrition, Exercise, and Screen Time Baseline Levels Prior to National Recommendations - p. 7 4. Compulsive Internet Use: The Role of Online Gaming and Other Internet Applications - p. 8 5. Adolescence Sleep Disturbances as Predictors of Adulthood Sleep Disturbances—A Cohort Study - p. 9 6. Effects of a Brief Intervention for Reducing Violence and Alcohol Misuse Among Adolescents: A Randomized Controlled Trial - p. 10 7. Comparison of Teenagers' Early Same-Sex and Heterosexual Behavior: UK Data From the SHARE and RIPPLE Studies - p. 11 8. Criminal-Justice and School Sanctions Against Nonheterosexual Youth: A National Longitudinal Study - p. 12 9. Use of Social Networking Sites in Online Sex Crimes Against Minors: An Examination of National Incidence and Means of Utilization - p. 13 10. Reasons for and Challenges of Recent Increases in Teen Birth Rates: A Study of Family Planning Service Policies and Demographic Changes at the State Level - p. 14 11. Recent Changes in the Trends of Teen Birth Rates, 1981–2006 - p. 15 12. How Are Restrictive Abortion Statutes Associated With Unintended Teen Birth? - p. 16 13. Induced First-Trimester Abortion and Risk of Mental Disorder - p. 17 14. Changes in Ambulatory Health Care Use During the Transition to Young Adulthood - p. 18 15. Nanofiltered C1 Inhibitor Concentrate for Treatment of Hereditary Angioedema - p. 19 16. Exposure to Environmental Microorganisms and Childhood Asthma - p. 20 17. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial - p. 21 18. Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children - p. 22 19. A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response - p. 23 20. The Prevalence of Infections With Trichophyton tonsurans in Schoolchildren: the CAPITIS Study - p. 24 21. Cost effectiveness of home ultraviolet B phototherapy for psoriasis: economic evaluation of a randomised controlled trial (PLUTO study) - p. 25 22. Prospective Study of Spinal Anomalies in Children with Infantile Hemangiomas of the Lumbosacral Skin - p. 26 23. LUMBAR: Association between Cutaneous Infantile Hemangiomas of the Lower Body and Regional Congenital Anomalies - p. 27 24. Efficacy of Propranolol in Hepatic Infantile Hemangiomas with Diffuse Neonatal Hemangiomatosis - p. 28 25. Mutations in GNA11 in Uveal Melanoma - p. 29 26. Red Blood Cell Morphology Reporting: How Much is a Waste of Time? - p. 30 27. The Etiology and Treatment Outcome of Iron Deficiency and Iron Deficiency Anemia in Children - p. 31 28. Orange But Not Apple Juice Enhances Ferrous Fumarate Absorption in Small Children - p. 32 29. Prevalence of Iron Deficiency in Children with Down Syndrome - p. 33 30. Sickle cell disease resulting from uniparental disomy in a child who inherited sickle cell trait - p. 34 31. Dietary Water and Sodium Intake of Children and Adolescents With Sickle Cell Anemia - p. 35 32. Neuropsychological Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adults With Sickle Cell Anemia - p. 36 33. Transcranial Doppler Ultrasonography and Prophylactic Transfusion Program Is Effective in Preventing Overt Stroke in Children with Sickle Cell Disease - p. 37 34. White Matter Integrity and Core Cognitive Function in Children Diagnosed With Sickle Cell Disease - p. 38 35. Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation - p. 39 36. Apparent Desaturation on Pulse Oximetry Because of Hemoglobinopathy - p. 40 37. Nucleic Acid Testing to Detect HBV Infection in Blood Donors - p. 41 38. Romiplostim or Standard of Care in Patients with Immune Thrombocytopenia - p. 42 39. Neoangiogenesis contributes to the development of hemophilic synovitis - p. 43 40. Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment - p. 44 41. Cost-utility analysis of von Willebrand disease screening in adolescents with menorrhagia - p. 45 42. Safety of Recombinant Activated Factor VII in Randomized Clinical Trials - p. 46 43. Difficulties in Diagnosing Congenital Thrombotic Thrombocytopenic Purpura - p. 47 44. High Prevalence of Thrombophilic Traits in Children with Family History of Thromboembolism - p. 48 45. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial - p. 49 46. Food Selectivity in Children with Autism Spectrum Disorders and Typically Developing Children - p. 50 47. Mitochondrial Dysfunction in Autism - p. 51 48. Lack of Association Between Measles-Mumps-Rubella Vaccination and Autism in Children: A Case-Control Study - p. 52 49. Predicting Persistence of and Recovery from Stuttering by the Teenage Years Based on Information Gathered at Age 8 Years - p. 53 50. Transient idiopathic dystonia in infancy - p. 54 51. Physician “Costs” in Providing Behavioral Health in Primary Care - p. 55 52. Toothache in US Children - p. 56 53. Preventive Oral Health Care in Early Childhood: Knowledge, Confidence, and Practices of Pediatricians and Family Physicians in Florida - p. 57 54. Fluoride Content of Water Used to Reconstitute Infant Formula - p. 58 55. Familial Cases of Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome - p. 59 56. Intraorbital and Intracranial Extension of Sinusitis: Comparative Morbidity - p. 60 57. Diagnosis, Microbial Epidemiology, and Antibiotic Treatment of Acute Otitis Media in Children: A Systematic Review - p. 61 58. A Placebo-Controlled Trial of Antimicrobial Treatment for Acute Otitis Media - p. 62 59. Treatment of Acute Otitis Media in Children under 2 Years of Age - p. 63 60. Newborn Hearing Screening vs Later Hearing Screening and Developmental Outcomes in Children With Permanent Childhood Hearing Impairment - p. 64 61. Change in Prevalence of Hearing Loss in US Adolescents - p. 65 62. Spoken Language Development in Children Following Cochlear Implantation - p. 66 63. A Genetic Basis for Functional Hypothalamic Amenorrhea - p. 67 64. A National Study of Physician Recommendations to Initiate and Discontinue Growth Hormone for Short Stature - p. 68 65. Variation in Methods of Predicting Adult Height for Children with Idiopathic Short Stature - p. 69 66. Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review - p. 70 67. Growth and Development of Male External Genitalia: A Cross-Sectional Study of 6200 Males Aged 0 to 19 Years - p. 71 68. Growth Hormone plus Childhood Low-Dose Estrogen in Turner's Syndrome - p. 72 69. The Effects of Growth Hormone on Body Composition and Physical Performance in Recreational Athletes: A Randomized Trial - p. 73 70. Newborn Screening Results in Children with Central Hypothyroidism - p. 74 71. Celiac Disease in Children, Adolescents, and Young Adults with Autoimmune Thyroid Disease - p. 76 72. Exposure to Helicobacter pylori–positive Siblings and Persistence of Helicobacter pylori Infection in Early Childhood - p. 77 73. Exchange Transfusion as a Possible Therapy for Neonatal Hemochromatosis - p. 78 74. Evidence for a Novel Blood RNA Diagnostic for Pediatric Appendicitis: The Riboleukogram - p. 79 75. Predictive indicators for bowel injury in pediatric patients who present with a positive seat belt sign after motor vehicle collision - p. 80 76. Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation - p. 81 77. VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Crossover Study - p. 82 78. Celiac Disease without Villous Atrophy in Children: A Prospective Study - p. 83 79. Inflammatory Bowel Disease Developing in Paediatric and Adult Age - p. 84 80. Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity - p. 85 81. Pediatric Inflammatory Bowel Disease and Imaging-related Radiation: Are We Increasing the Likelihood of Malignancy? - p. 86 82. Familial Adenomatous Polyposis in Children and Adolescents - p. 87 83. Direct Medical Costs of Constipation From Childhood to Early Adulthood: A Population-based Birth Cohort Study - p. 88 84. Prospective Evaluation of Dietary Treatment in Childhood Constipation: High Dietary Fiber and Wheat Bran Intake Are Associated With Constipation Amelioration - p. 89 85. Cow's-Milk–free Diet as a Therapeutic Option in Childhood Chronic Constipation - p. 90 86. Creation and Initial Evaluation of a Stool Form Scale for Children - p. 91 87. Risk of Nephropathy After Consumption of Nonionic Contrast Media by Children Undergoing Cardiac Angiography: A Prospective Study - p. 92 88. Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study - p. 93 89. Using Proteinuria and Estimated Glomerular Filtration Rate to Classify Risk in Patients With Chronic Kidney Disease: A Cohort Study - p. 94 90. Time for Initial Response to Steroids Is a Major Prognostic Factor in Idiopathic Nephrotic Syndrome - p. 95 91. Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease - p. 96 92. The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults - p. 97 93. Meta-analysis: Erythropoiesis-Stimulating Agents in Patients With Chronic Kidney Disease - p. 98 94. A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis - p. 99 95. Regulated Payments for Living Kidney Donation: An Empirical Assessment of the Ethical Concerns - p. 100 96. Dextranomer/Hyaluronic Acid for Pediatric Vesicoureteral Reflux: Systematic Review - p. 102 97. Risk of Renal Scarring in Children With a First Urinary Tract Infection: A Systematic Review - p. 103 98. Laparoscopic inguinal hernia repair in the pediatric age group—experience with 437 children - p. 104 99. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial - p. 105 100. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis - p. 106 101. Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis - p. 107 102. Endothelial Abnormalities in Adolescents with Type 1 Diabetes: A Biomarker for Vascular Sequelae? - p. 108 103. Preclinical Noninvasive Markers of Atherosclerosis in Children and Adolescents with Type 1 Diabetes Are Influenced by Physical Activity - p. 109 104. Ventricular Tachyarrhythmias after Cardiac Arrest in Public versus at Home - p. 110 105. Compression-Only CPR or Standard CPR in Out-of-Hospital Cardiac Arrest - p. 112 106. Chest Compression–Only CPR by Lay Rescuers and Survival From Out-of-Hospital Cardiac Arrest - p. 113 107. CPR with Chest Compression Alone or with Rescue Breathing - p. 114 108. Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial - p. 115 109. Effectiveness and Cost-Effectiveness of Blood Pressure Screening in Adolescents in the United States - p. 117 110. Comparison of Shunt Types in the Norwood Procedure for Single-Ventricle Lesions - p. 118 111. Care of the Adult Congenital Heart Disease Patient in the United States: A Summary of the Current System - p. 120 112. Intermediate-Term Effects of Transcatheter Secundum Atrial Septal Defect Closure on Cardiac Remodeling in Children and Adults - p. 121 113. Outcome of Isolated Bicuspid Aortic Valve in Childhood - p. 122 114. Percutaneous Repair or Surgery for Mitral Regurgitation - p. 123 115. Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial - p. 124 116. Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice - p. 125 117. The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses - p. 126 118. Extreme leucocytosis and the risk of serious bacterial infections in febrile children - p. 128 119. Fidaxomicin versus Vancomycin for Clostridium difficile Infection - p. 129 120. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial - p. 130 121. Probable Zoonotic Leprosy in the Southern United States - p. 131 122. Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay - p. 132 123. Inhibitory Effect of Breast Milk on Infectivity of Live Oral Rotavirus Vaccines - p. 133 124. Dissolving polymer microneedle patches for influenza vaccination - p. 134 125. Burden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008 - p. 135 126. Use of Screening Dried Blood Spots for Estimation of Prevalence, Risk Factors, and Birth Outcomes of Congenital Cytomegalovirus Infection - p. 136 127. Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial - p. 137 128. Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda - p. 138 129. Vaccine-Induced HIV Seropositivity/Reactivity in Noninfected HIV Vaccine Recipients - p. 139 130. Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men - p. 140 131. Antiretroviral Therapies in Women after Single-Dose Nevirapine Exposure - p. 141 132. Antiretroviral Treatment for Children with Peripartum Nevirapine Exposure - p. 142 133. Focal Epithelial Hyperplasia Caused by Human Papillomavirus 13 - p. 143 134. Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males - p. 144 135. Incidence and clearance of genital human papillomavirus infection in men (HIM): a cohort study - p. 145 136. Human Papillomavirus Vaccination of Males: Attitudes and Perceptions of Physicians Who Vaccinate Females - p. 146 137. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China - p. 147 138. Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome - p. 148 139. Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screening - p. 149 140. Errors of Diagnosis in Pediatric Practice: A Multisite Survey - p. 150 141. Epidemiology and aetiology of paediatric malpractice claims in France - p. 152 142. Googling children's health: reliability of medical advice on the internet - p. 153 143. Underinsurance among Children in the United States - p. 154 144. Pediatric Emergency Department Use by Adults With Chronic Pediatric Disorders - p. 156 145. Clinical assessment incorporating a personal genome - p. 157 146. Which Pediatricians Are Providing Care to America's Children? An Update on the Trends and Changes During the Past 26 Years - p. 158 147. Geographic Maldistribution of Primary Care for Children - p. 159 148. Primary Care Pediatricians' Satisfaction with Subspecialty Care, Perceived Supply, and Barriers to Care - p. 160 149. Pediatric Nurse Practitioners in the United States: Current Distribution and Recent Trends in Training - p. 161 150. The Social Mission of Medical Education: Ranking the Schools - p. 162 151. Online Posting of Unprofessional Content by Medical Students - p. 165 152. Relationship Between Burnout and Professional Conduct and Attitudes Among US Medical Students - p. 166 153. Plagiarism in Residency Application Essays - p. 167 154. A Randomized Trial of Tai Chi for Fibromyalgia - p. 168 155. Adolescent Chronic Fatigue Syndrome: A Follow-up Study - p. 169 156. Do children who in-toe need to be referred to an orthopaedic clinic? - p. 170 157. Risk of Injury Associated With Body Checking Among Youth Ice Hockey Players - p. 171 158. Escalators, Rubber Clogs, and Severe Foot Injuries in Children - p. 172 159. Prognostic Impact of Atypical Presentation in Pediatric Systemic Lupus Erythematosus: Results from a Multicenter Study - p. 173 160. Familial Mediterranean Fever in the First Two Years of Life: A Unique Phenotype of Disease in Evolution - p. 174 161. United States Head Circumference Growth Reference Charts: Birth to 21 Years - p. 175 162. Postnatal-Onset Microcephaly: Pathogenesis, Patterns of Growth, and Prediction of Outcome - p. 176 163. Childhood Predictors of Use and Costs of Antidepressant Medication by Age 24 Years: Findings from the Finnish Nationwide 1981 Birth Cohort Study - p. 177 164. Out-of-Hospital Hypertonic Resuscitation Following Severe Traumatic Brain Injury: A Randomized Controlled Trial - p. 178 165. Pediatric Concussions in United States Emergency Departments in the Years 2002 to 2006 - p. 179 166. Decompressive Craniectomy in Diffuse Traumatic Brain Injury - p. 180 167. “Traumatic Tap” Proportion in Pediatric Lumbar Puncture - p. 181 168. A clinical prediction rule for ambulation outcomes after traumatic spinal cord injury: a longitudinal cohort study - p. 182 169. Botulinumtoxin A treatment in toddlers with cerebral palsy - p. 183 170. The epidemiology of progressive intellectual and neurological deterioration in childhood - p. 184 171. Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study - p. 185 172. L-Histidine Decarboxylase and Tourette's Syndrome - p. 186 173. Behavior Therapy for Children With Tourette Disorder: A Randomized Controlled Trial - p. 187 174. Nonpharmacological Treatment of Tics in Tourette Syndrome Adding Videotape Training to Self-Hypnosis - p. 188 175. Long-Term Mortality in Childhood-Onset Epilepsy - p. 189 176. Course and outcome of childhood epilepsy: A 15-year follow-up of the Dutch Study of Epilepsy in Childhood - p. 190 177. Patterns of Nonadherence to Antiepileptic Drug Therapy in Children With Newly Diagnosed Epilepsy - p. 191 178. Suicide-Related Events in Patients Treated with Antiepileptic Drugs - p. 192 179. Screening, Triage, and Referral of Patients Who Report Suicidal Thought During a Primary Care Visit - p. 193 180. Comparative Safety of Antidepressant Agents for Children and Adolescents Regarding Suicidal Acts - p. 194 181. Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A) - p. 195 182. Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study - p. 196 183. Depression, Stigma, and Suicidal Ideation in Medical Students - p. 197 184. Effect of a barrier at Bloor Street Viaduct on suicide rates in Toronto: natural experiment - p. 198 185. Perinatal Regionalization for Very Low-Birth-Weight and Very Preterm Infants: A Meta-Analysis - p. 199 186. Time of birth and risk of neonatal death at term: retrospective cohort study - p. 200 187. Respiratory Morbidity in Late Preterm Births - p. 201 188. Cerebral Palsy Among Term and Postterm Births - p. 202 189. A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele - p. 203 190. Continuous Glucose Monitoring in Newborn Babies at Risk of Hypoglycemia - p. 204 191. Hour-Specific Bilirubin Nomogram in Infants With ABO Incompatibility and Direct Coombs-Positive Results - p. 205 192. Neonatal non-hemolytic hyperbilirubinemia: a prevalence study of adult neuropsychiatric disability and cognitive function in 463 male Danish conscripts - p. 206 193. Methaemoglobinaemia risk factors with inhaled nitric oxide therapy in newborn infants - p. 207 194. Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial - p. 208 195. Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure - p. 209 196. Secondhand Smoke and Adverse Fetal Outcomes in Nonsmoking Pregnant Women: A Meta-analysis - p. 210 197. Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial - p. 211 198. Hemolysis and Hyperbilirubinemia in Antiglobulin Positive, Direct ABO Blood Group Heterospecific Neonates - p. 212 199. Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomised control trial - p. 213 200. Target Ranges of Oxygen Saturation in Extremely Preterm Infants - p. 214 201. Early CPAP versus Surfactant in Extremely Preterm Infants - p. 215 202. Early Surgical Ligation Versus a Conservative Approach for Management of Patent Ductus Arteriosus That Fails to Close after Indomethacin Treatment - p. 216 203. Transfusion-Related Acute Gut Injury: Necrotizing Enterocolitis in Very Low Birth Weight Neonates after Packed Red Blood Cell Transfusion - p. 217 204. Impact of Breast Milk on Intelligence Quotient, Brain Size, and White Matter Development - p. 218 205. Maternal and Neonatal Vitamin B12 Deficiency Detected through Expanded Newborn Screening—United States, 2003–2007 - p. 219 206. Infant Obesity: Are We Ready to Make this Diagnosis? - p. 220 207. Infant Overweight Is Associated with Delayed Motor Development - p. 221 208. Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease - p. 222 209. Association of Adolescent Obesity With Risk of Severe Obesity in Adulthood - p. 223 210. Comorbidities of overweight/obesity experienced in adolescence: longitudinal study - p. 224 211. Caloric Sweetener Consumption and Dyslipidemia Among US Adults - p. 225 212. Association of Maternal Stature With Offspring Mortality, Underweight, and Stunting in Low- to Middle-Income Countries - p. 226 213. Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children: A Randomized Controlled Trial - p. 227 214. Low 25-Hydroxyvitamin D Levels in Adolescents: Race, Season, Adiposity, Physical Activity, and Fitness - p. 228 215. Common genetic determinants of vitamin D insufficiency: a genome-wide association study - p. 229 216. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis - p. 230 217. Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents: The TONIC Randomized Controlled Trial - p. 231 218. Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 - p. 232 219. Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity - p. 233 220. Functional Variants of the HMGA1 Gene and Type 2 Diabetes Mellitus - p. 234 221. Celiac Autoimmunity in Children with Type 1 Diabetes: A Two-Year Follow-Up - p. 235 222. Attitudes and Practices of Oncologists Toward Fertility Preservation - p. 236 223. Single-Dose Palifermin Prevents Severe Oral Mucositis During Multicycle Chemotherapy in Patients With Cancer: A Randomized Trial - p. 237 224. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial - p. 238 225. MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia - p. 239 226. Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group - p. 240 227. Hematopoietic Stem Cell Transplantation: A Global Perspective - p. 241 228. Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study - p. 242 229. Outcome after Reduced Chemotherapy for Intermediate-Risk Neuroblastoma - p. 243 230. Papillary Thyroid Cancer in Children and Adolescents Does Not Differ in Growth Pattern and Metastatic Behavior - p. 244 231. Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis - p. 245 232. Everolimus for Advanced Pancreatic Neuroendocrine Tumors - p. 246 233. Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer - p. 247 234. Late Onset Hearing Loss: A Significant Complication of Cancer Survivors Treated With Cisplatin Containing Chemotherapy Regimens - p. 248 235. Long-term Cause-Specific Mortality Among Survivors of Childhood Cancer - p. 249 236. Growth Hormone Treatment in Children is not Associated with an Increase in the Incidence of Cancer: Experience from KIGS (Pfizer International Growth Database) - p. 250 237. Screening and Surveillance for Second Malignant Neoplasms in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study - p. 251 238. Stillbirth and neonatal death in relation to radiation exposure before conception: a retrospective cohort study - p. 252 239. Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study - p. 253 240. Mobile phone base stations and early childhood cancers: case-control study - p. 254 241. Perinatal Systemic Inflammatory Response Syndrome and Retinopathy of Prematurity - p. 255 242. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity - p. 256 243. A Higher Incidence of Intermittent Hypoxemic Episodes Is Associated with Severe Retinopathy of Prematurity - p. 257 244. Complications and Visual Prognosis in Children With Aniridia - p. 258 245. Is a 6-Week Course of Ganciclovir Therapy Effective for Chorioretinitis in Infants with Congenital Cytomegalovirus Infection? - p. 259 246. Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies - p. 260 247. Maternal Vitamin A Supplementation and Lung Function in Offspring - p. 261 248. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma - p. 262 249. Smoke-free Legislation and Hospitalizations for Childhood Asthma - p. 263 250. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis - p. 264 251. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis - p. 265 252. Lack of Predictive Value of Tachypnea in the Diagnosis of Pneumonia in Children - p. 266 253. Ambulatory Visit Rates and Antibiotic Prescribing for Children With Pneumonia, 1994–2007 - p. 267 254. Does sweat volume influence the sweat test result? - p. 268 255. Effect of Azithromycin on Pulmonary Function in Patients With Cystic Fibrosis Uninfected With Pseudomonas aeruginosa: A Randomized Controlled Trial - p. 269 256. Infection With Transmissible Strains of Pseudomonas aeruginosa and Clinical Outcomes in Adults With Cystic Fibrosis - p. 270 257. Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation - p. 271 258. The Epidemiology of Prescriptions Abandoned at the Pharmacy - p. 272 259. Malicious Use of Pharmaceuticals in Children - p. 273 260. Evaluation of Consistency in Dosing Directions and Measuring Devices for Pediatric Nonprescription Liquid Medications - p. 274 261. Adverse Events From Cough and Cold Medications After a Market Withdrawal of Products Labeled for Infants - p. 275 262. Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms - p. 276 263. Two Unusual Pediatric Cases of Dilutional Hyponatremia - p. 277 264. HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans - p. 278 265. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids - p. 279 266. A Family-based Randomized Controlled Trial of Pain Intervention for Adolescents With Sickle Cell Disease - p. 280 267. Glowing in the dark: time of day as a determinant of radiographic imaging in the evaluation of abdominal pain in children - p. 281 268. Inflammatory Effects of Phthalates in Neonatal Neutrophils - p. 282 269. Hair Mercury Levels of Women of Reproductive Age in Ontario, Canada: Implications to Fetal Safety and Fish Consumption - p. 283 270. Acute Ethanol Poisoning in a 4-Year-Old as a Result of Ethanol-Based Hand-Sanitizer Ingestion - p. 284 271. Initial Location Determines Spontaneous Passage of Foreign Bodies From the Gastrointestinal Tract in Children - p. 285 272. Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial - p. 286 273. Inhalant Abuse: Monitoring Trends by Using Poison Control Data, 1993–2008 - p. 287 274. Unintentional Child Poisonings Through Ingestion of Conventional and Novel Tobacco Products - p. 288
The Year Book of Pediatrics brings you abstracts of the articles that reported the year's breakthrough developments in pediatrics, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! This annual covers all aspects of pediatric care from infectious diseases and immunology, adolescent medicine, therapeutics and toxicology, child development, dentistry and otolaryngology and neurology and psychiatry. The Year Book of Pediatrics publishes annually in December of the preceding year.
1. Cover - p. 1 2. Contents - p. 2 3. US Adolescent Nutrition, Exercise, and Screen Time Baseline Levels Prior to National Recommendations - p. 7 4. Compulsive Internet Use: The Role of Online Gaming and Other Internet Applications - p. 8 5. Adolescence Sleep Disturbances as Predictors of Adulthood Sleep Disturbances—A Cohort Study - p. 9 6. Effects of a Brief Intervention for Reducing Violence and Alcohol Misuse Among Adolescents: A Randomized Controlled Trial - p. 10 7. Comparison of Teenagers' Early Same-Sex and Heterosexual Behavior: UK Data From the SHARE and RIPPLE Studies - p. 11 8. Criminal-Justice and School Sanctions Against Nonheterosexual Youth: A National Longitudinal Study - p. 12 9. Use of Social Networking Sites in Online Sex Crimes Against Minors: An Examination of National Incidence and Means of Utilization - p. 13 10. Reasons for and Challenges of Recent Increases in Teen Birth Rates: A Study of Family Planning Service Policies and Demographic Changes at the State Level - p. 14 11. Recent Changes in the Trends of Teen Birth Rates, 1981–2006 - p. 15 12. How Are Restrictive Abortion Statutes Associated With Unintended Teen Birth? - p. 16 13. Induced First-Trimester Abortion and Risk of Mental Disorder - p. 17 14. Changes in Ambulatory Health Care Use During the Transition to Young Adulthood - p. 18 15. Nanofiltered C1 Inhibitor Concentrate for Treatment of Hereditary Angioedema - p. 19 16. Exposure to Environmental Microorganisms and Childhood Asthma - p. 20 17. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial - p. 21 18. Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children - p. 22 19. A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response - p. 23 20. The Prevalence of Infections With Trichophyton tonsurans in Schoolchildren: the CAPITIS Study - p. 24 21. Cost effectiveness of home ultraviolet B phototherapy for psoriasis: economic evaluation of a randomised controlled trial (PLUTO study) - p. 25 22. Prospective Study of Spinal Anomalies in Children with Infantile Hemangiomas of the Lumbosacral Skin - p. 26 23. LUMBAR: Association between Cutaneous Infantile Hemangiomas of the Lower Body and Regional Congenital Anomalies - p. 27 24. Efficacy of Propranolol in Hepatic Infantile Hemangiomas with Diffuse Neonatal Hemangiomatosis - p. 28 25. Mutations in GNA11 in Uveal Melanoma - p. 29 26. Red Blood Cell Morphology Reporting: How Much is a Waste of Time? - p. 30 27. The Etiology and Treatment Outcome of Iron Deficiency and Iron Deficiency Anemia in Children - p. 31 28. Orange But Not Apple Juice Enhances Ferrous Fumarate Absorption in Small Children - p. 32 29. Prevalence of Iron Deficiency in Children with Down Syndrome - p. 33 30. Sickle cell disease resulting from uniparental disomy in a child who inherited sickle cell trait - p. 34 31. Dietary Water and Sodium Intake of Children and Adolescents With Sickle Cell Anemia - p. 35 32. Neuropsychological Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adults With Sickle Cell Anemia - p. 36 33. Transcranial Doppler Ultrasonography and Prophylactic Transfusion Program Is Effective in Preventing Overt Stroke in Children with Sickle Cell Disease - p. 37 34. White Matter Integrity and Core Cognitive Function in Children Diagnosed With Sickle Cell Disease - p. 38 35. Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation - p. 39 36. Apparent Desaturation on Pulse Oximetry Because of Hemoglobinopathy - p. 40 37. Nucleic Acid Testing to Detect HBV Infection in Blood Donors - p. 41 38. Romiplostim or Standard of Care in Patients with Immune Thrombocytopenia - p. 42 39. Neoangiogenesis contributes to the development of hemophilic synovitis - p. 43 40. Rational design of a fully active, long-acting PEGylated factor VIII for hemophilia A treatment - p. 44 41. Cost-utility analysis of von Willebrand disease screening in adolescents with menorrhagia - p. 45 42. Safety of Recombinant Activated Factor VII in Randomized Clinical Trials - p. 46 43. Difficulties in Diagnosing Congenital Thrombotic Thrombocytopenic Purpura - p. 47 44. High Prevalence of Thrombophilic Traits in Children with Family History of Thromboembolism - p. 48 45. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial - p. 49 46. Food Selectivity in Children with Autism Spectrum Disorders and Typically Developing Children - p. 50 47. Mitochondrial Dysfunction in Autism - p. 51 48. Lack of Association Between Measles-Mumps-Rubella Vaccination and Autism in Children: A Case-Control Study - p. 52 49. Predicting Persistence of and Recovery from Stuttering by the Teenage Years Based on Information Gathered at Age 8 Years - p. 53 50. Transient idiopathic dystonia in infancy - p. 54 51. Physician “Costs” in Providing Behavioral Health in Primary Care - p. 55 52. Toothache in US Children - p. 56 53. Preventive Oral Health Care in Early Childhood: Knowledge, Confidence, and Practices of Pediatricians and Family Physicians in Florida - p. 57 54. Fluoride Content of Water Used to Reconstitute Infant Formula - p. 58 55. Familial Cases of Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome - p. 59 56. Intraorbital and Intracranial Extension of Sinusitis: Comparative Morbidity - p. 60 57. Diagnosis, Microbial Epidemiology, and Antibiotic Treatment of Acute Otitis Media in Children: A Systematic Review - p. 61 58. A Placebo-Controlled Trial of Antimicrobial Treatment for Acute Otitis Media - p. 62 59. Treatment of Acute Otitis Media in Children under 2 Years of Age - p. 63 60. Newborn Hearing Screening vs Later Hearing Screening and Developmental Outcomes in Children With Permanent Childhood Hearing Impairment - p. 64 61. Change in Prevalence of Hearing Loss in US Adolescents - p. 65 62. Spoken Language Development in Children Following Cochlear Implantation - p. 66 63. A Genetic Basis for Functional Hypothalamic Amenorrhea - p. 67 64. A National Study of Physician Recommendations to Initiate and Discontinue Growth Hormone for Short Stature - p. 68 65. Variation in Methods of Predicting Adult Height for Children with Idiopathic Short Stature - p. 69 66. Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review - p. 70 67. Growth and Development of Male External Genitalia: A Cross-Sectional Study of 6200 Males Aged 0 to 19 Years - p. 71 68. Growth Hormone plus Childhood Low-Dose Estrogen in Turner's Syndrome - p. 72 69. The Effects of Growth Hormone on Body Composition and Physical Performance in Recreational Athletes: A Randomized Trial - p. 73 70. Newborn Screening Results in Children with Central Hypothyroidism - p. 74 71. Celiac Disease in Children, Adolescents, and Young Adults with Autoimmune Thyroid Disease - p. 76 72. Exposure to Helicobacter pylori–positive Siblings and Persistence of Helicobacter pylori Infection in Early Childhood - p. 77 73. Exchange Transfusion as a Possible Therapy for Neonatal Hemochromatosis - p. 78 74. Evidence for a Novel Blood RNA Diagnostic for Pediatric Appendicitis: The Riboleukogram - p. 79 75. Predictive indicators for bowel injury in pediatric patients who present with a positive seat belt sign after motor vehicle collision - p. 80 76. Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation - p. 81 77. VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo-Controlled, Double-Blind, Crossover Study - p. 82 78. Celiac Disease without Villous Atrophy in Children: A Prospective Study - p. 83 79. Inflammatory Bowel Disease Developing in Paediatric and Adult Age - p. 84 80. Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity - p. 85 81. Pediatric Inflammatory Bowel Disease and Imaging-related Radiation: Are We Increasing the Likelihood of Malignancy? - p. 86 82. Familial Adenomatous Polyposis in Children and Adolescents - p. 87 83. Direct Medical Costs of Constipation From Childhood to Early Adulthood: A Population-based Birth Cohort Study - p. 88 84. Prospective Evaluation of Dietary Treatment in Childhood Constipation: High Dietary Fiber and Wheat Bran Intake Are Associated With Constipation Amelioration - p. 89 85. Cow's-Milk–free Diet as a Therapeutic Option in Childhood Chronic Constipation - p. 90 86. Creation and Initial Evaluation of a Stool Form Scale for Children - p. 91 87. Risk of Nephropathy After Consumption of Nonionic Contrast Media by Children Undergoing Cardiac Angiography: A Prospective Study - p. 92 88. Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study - p. 93 89. Using Proteinuria and Estimated Glomerular Filtration Rate to Classify Risk in Patients With Chronic Kidney Disease: A Cohort Study - p. 94 90. Time for Initial Response to Steroids Is a Major Prognostic Factor in Idiopathic Nephrotic Syndrome - p. 95 91. Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease - p. 96 92. The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults - p. 97 93. Meta-analysis: Erythropoiesis-Stimulating Agents in Patients With Chronic Kidney Disease - p. 98 94. A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis - p. 99 95. Regulated Payments for Living Kidney Donation: An Empirical Assessment of the Ethical Concerns - p. 100 96. Dextranomer/Hyaluronic Acid for Pediatric Vesicoureteral Reflux: Systematic Review - p. 102 97. Risk of Renal Scarring in Children With a First Urinary Tract Infection: A Systematic Review - p. 103 98. Laparoscopic inguinal hernia repair in the pediatric age group—experience with 437 children - p. 104 99. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial - p. 105 100. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis - p. 106 101. Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis - p. 107 102. Endothelial Abnormalities in Adolescents with Type 1 Diabetes: A Biomarker for Vascular Sequelae? - p. 108 103. Preclinical Noninvasive Markers of Atherosclerosis in Children and Adolescents with Type 1 Diabetes Are Influenced by Physical Activity - p. 109 104. Ventricular Tachyarrhythmias after Cardiac Arrest in Public versus at Home - p. 110 105. Compression-Only CPR or Standard CPR in Out-of-Hospital Cardiac Arrest - p. 112 106. Chest Compression–Only CPR by Lay Rescuers and Survival From Out-of-Hospital Cardiac Arrest - p. 113 107. CPR with Chest Compression Alone or with Rescue Breathing - p. 114 108. Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial - p. 115 109. Effectiveness and Cost-Effectiveness of Blood Pressure Screening in Adolescents in the United States - p. 117 110. Comparison of Shunt Types in the Norwood Procedure for Single-Ventricle Lesions - p. 118 111. Care of the Adult Congenital Heart Disease Patient in the United States: A Summary of the Current System - p. 120 112. Intermediate-Term Effects of Transcatheter Secundum Atrial Septal Defect Closure on Cardiac Remodeling in Children and Adults - p. 121 113. Outcome of Isolated Bicuspid Aortic Valve in Childhood - p. 122 114. Percutaneous Repair or Surgery for Mitral Regurgitation - p. 123 115. Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial - p. 124 116. Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice - p. 125 117. The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses - p. 126 118. Extreme leucocytosis and the risk of serious bacterial infections in febrile children - p. 128 119. Fidaxomicin versus Vancomycin for Clostridium difficile Infection - p. 129 120. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial - p. 130 121. Probable Zoonotic Leprosy in the Southern United States - p. 131 122. Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay - p. 132 123. Inhibitory Effect of Breast Milk on Infectivity of Live Oral Rotavirus Vaccines - p. 133 124. Dissolving polymer microneedle patches for influenza vaccination - p. 134 125. Burden of Seasonal Influenza Hospitalization in Children, United States, 2003 to 2008 - p. 135 126. Use of Screening Dried Blood Spots for Estimation of Prevalence, Risk Factors, and Birth Outcomes of Congenital Cytomegalovirus Infection - p. 136 127. Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial - p. 137 128. Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative women: a randomised trial in Rakai, Uganda - p. 138 129. Vaccine-Induced HIV Seropositivity/Reactivity in Noninfected HIV Vaccine Recipients - p. 139 130. Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men - p. 140 131. Antiretroviral Therapies in Women after Single-Dose Nevirapine Exposure - p. 141 132. Antiretroviral Treatment for Children with Peripartum Nevirapine Exposure - p. 142 133. Focal Epithelial Hyperplasia Caused by Human Papillomavirus 13 - p. 143 134. Efficacy of Quadrivalent HPV Vaccine against HPV Infection and Disease in Males - p. 144 135. Incidence and clearance of genital human papillomavirus infection in men (HIM): a cohort study - p. 145 136. Human Papillomavirus Vaccination of Males: Attitudes and Perceptions of Physicians Who Vaccinate Females - p. 146 137. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China - p. 147 138. Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome - p. 148 139. Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screening - p. 149 140. Errors of Diagnosis in Pediatric Practice: A Multisite Survey - p. 150 141. Epidemiology and aetiology of paediatric malpractice claims in France - p. 152 142. Googling children's health: reliability of medical advice on the internet - p. 153 143. Underinsurance among Children in the United States - p. 154 144. Pediatric Emergency Department Use by Adults With Chronic Pediatric Disorders - p. 156 145. Clinical assessment incorporating a personal genome - p. 157 146. Which Pediatricians Are Providing Care to America's Children? An Update on the Trends and Changes During the Past 26 Years - p. 158 147. Geographic Maldistribution of Primary Care for Children - p. 159 148. Primary Care Pediatricians' Satisfaction with Subspecialty Care, Perceived Supply, and Barriers to Care - p. 160 149. Pediatric Nurse Practitioners in the United States: Current Distribution and Recent Trends in Training - p. 161 150. The Social Mission of Medical Education: Ranking the Schools - p. 162 151. Online Posting of Unprofessional Content by Medical Students - p. 165 152. Relationship Between Burnout and Professional Conduct and Attitudes Among US Medical Students - p. 166 153. Plagiarism in Residency Application Essays - p. 167 154. A Randomized Trial of Tai Chi for Fibromyalgia - p. 168 155. Adolescent Chronic Fatigue Syndrome: A Follow-up Study - p. 169 156. Do children who in-toe need to be referred to an orthopaedic clinic? - p. 170 157. Risk of Injury Associated With Body Checking Among Youth Ice Hockey Players - p. 171 158. Escalators, Rubber Clogs, and Severe Foot Injuries in Children - p. 172 159. Prognostic Impact of Atypical Presentation in Pediatric Systemic Lupus Erythematosus: Results from a Multicenter Study - p. 173 160. Familial Mediterranean Fever in the First Two Years of Life: A Unique Phenotype of Disease in Evolution - p. 174 161. United States Head Circumference Growth Reference Charts: Birth to 21 Years - p. 175 162. Postnatal-Onset Microcephaly: Pathogenesis, Patterns of Growth, and Prediction of Outcome - p. 176 163. Childhood Predictors of Use and Costs of Antidepressant Medication by Age 24 Years: Findings from the Finnish Nationwide 1981 Birth Cohort Study - p. 177 164. Out-of-Hospital Hypertonic Resuscitation Following Severe Traumatic Brain Injury: A Randomized Controlled Trial - p. 178 165. Pediatric Concussions in United States Emergency Departments in the Years 2002 to 2006 - p. 179 166. Decompressive Craniectomy in Diffuse Traumatic Brain Injury - p. 180 167. “Traumatic Tap” Proportion in Pediatric Lumbar Puncture - p. 181 168. A clinical prediction rule for ambulation outcomes after traumatic spinal cord injury: a longitudinal cohort study - p. 182 169. Botulinumtoxin A treatment in toddlers with cerebral palsy - p. 183 170. The epidemiology of progressive intellectual and neurological deterioration in childhood - p. 184 171. Streptococcal Upper Respiratory Tract Infections and Exacerbations of Tic and Obsessive-Compulsive Symptoms: A Prospective Longitudinal Study - p. 185 172. L-Histidine Decarboxylase and Tourette's Syndrome - p. 186 173. Behavior Therapy for Children With Tourette Disorder: A Randomized Controlled Trial - p. 187 174. Nonpharmacological Treatment of Tics in Tourette Syndrome Adding Videotape Training to Self-Hypnosis - p. 188 175. Long-Term Mortality in Childhood-Onset Epilepsy - p. 189 176. Course and outcome of childhood epilepsy: A 15-year follow-up of the Dutch Study of Epilepsy in Childhood - p. 190 177. Patterns of Nonadherence to Antiepileptic Drug Therapy in Children With Newly Diagnosed Epilepsy - p. 191 178. Suicide-Related Events in Patients Treated with Antiepileptic Drugs - p. 192 179. Screening, Triage, and Referral of Patients Who Report Suicidal Thought During a Primary Care Visit - p. 193 180. Comparative Safety of Antidepressant Agents for Children and Adolescents Regarding Suicidal Acts - p. 194 181. Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A) - p. 195 182. Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study - p. 196 183. Depression, Stigma, and Suicidal Ideation in Medical Students - p. 197 184. Effect of a barrier at Bloor Street Viaduct on suicide rates in Toronto: natural experiment - p. 198 185. Perinatal Regionalization for Very Low-Birth-Weight and Very Preterm Infants: A Meta-Analysis - p. 199 186. Time of birth and risk of neonatal death at term: retrospective cohort study - p. 200 187. Respiratory Morbidity in Late Preterm Births - p. 201 188. Cerebral Palsy Among Term and Postterm Births - p. 202 189. A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele - p. 203 190. Continuous Glucose Monitoring in Newborn Babies at Risk of Hypoglycemia - p. 204 191. Hour-Specific Bilirubin Nomogram in Infants With ABO Incompatibility and Direct Coombs-Positive Results - p. 205 192. Neonatal non-hemolytic hyperbilirubinemia: a prevalence study of adult neuropsychiatric disability and cognitive function in 463 male Danish conscripts - p. 206 193. Methaemoglobinaemia risk factors with inhaled nitric oxide therapy in newborn infants - p. 207 194. Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial - p. 208 195. Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure - p. 209 196. Secondhand Smoke and Adverse Fetal Outcomes in Nonsmoking Pregnant Women: A Meta-analysis - p. 210 197. Effectiveness of antenatal corticosteroids in reducing respiratory disorders in late preterm infants: randomised clinical trial - p. 211 198. Hemolysis and Hyperbilirubinemia in Antiglobulin Positive, Direct ABO Blood Group Heterospecific Neonates - p. 212 199. Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomised control trial - p. 213 200. Target Ranges of Oxygen Saturation in Extremely Preterm Infants - p. 214 201. Early CPAP versus Surfactant in Extremely Preterm Infants - p. 215 202. Early Surgical Ligation Versus a Conservative Approach for Management of Patent Ductus Arteriosus That Fails to Close after Indomethacin Treatment - p. 216 203. Transfusion-Related Acute Gut Injury: Necrotizing Enterocolitis in Very Low Birth Weight Neonates after Packed Red Blood Cell Transfusion - p. 217 204. Impact of Breast Milk on Intelligence Quotient, Brain Size, and White Matter Development - p. 218 205. Maternal and Neonatal Vitamin B12 Deficiency Detected through Expanded Newborn Screening—United States, 2003–2007 - p. 219 206. Infant Obesity: Are We Ready to Make this Diagnosis? - p. 220 207. Infant Overweight Is Associated with Delayed Motor Development - p. 221 208. Adolescent BMI Trajectory and Risk of Diabetes versus Coronary Disease - p. 222 209. Association of Adolescent Obesity With Risk of Severe Obesity in Adulthood - p. 223 210. Comorbidities of overweight/obesity experienced in adolescence: longitudinal study - p. 224 211. Caloric Sweetener Consumption and Dyslipidemia Among US Adults - p. 225 212. Association of Maternal Stature With Offspring Mortality, Underweight, and Stunting in Low- to Middle-Income Countries - p. 226 213. Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children: A Randomized Controlled Trial - p. 227 214. Low 25-Hydroxyvitamin D Levels in Adolescents: Race, Season, Adiposity, Physical Activity, and Fitness - p. 228 215. Common genetic determinants of vitamin D insufficiency: a genome-wide association study - p. 229 216. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis - p. 230 217. Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents: The TONIC Randomized Controlled Trial - p. 231 218. Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5 - p. 232 219. Dietary Intervention in Infancy and Later Signs of Beta-Cell Autoimmunity - p. 233 220. Functional Variants of the HMGA1 Gene and Type 2 Diabetes Mellitus - p. 234 221. Celiac Autoimmunity in Children with Type 1 Diabetes: A Two-Year Follow-Up - p. 235 222. Attitudes and Practices of Oncologists Toward Fertility Preservation - p. 236 223. Single-Dose Palifermin Prevents Severe Oral Mucositis During Multicycle Chemotherapy in Patients With Cancer: A Randomized Trial - p. 237 224. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial - p. 238 225. MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia - p. 239 226. Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group - p. 240 227. Hematopoietic Stem Cell Transplantation: A Global Perspective - p. 241 228. Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study - p. 242 229. Outcome after Reduced Chemotherapy for Intermediate-Risk Neuroblastoma - p. 243 230. Papillary Thyroid Cancer in Children and Adolescents Does Not Differ in Growth Pattern and Metastatic Behavior - p. 244 231. Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis - p. 245 232. Everolimus for Advanced Pancreatic Neuroendocrine Tumors - p. 246 233. Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer - p. 247 234. Late Onset Hearing Loss: A Significant Complication of Cancer Survivors Treated With Cisplatin Containing Chemotherapy Regimens - p. 248 235. Long-term Cause-Specific Mortality Among Survivors of Childhood Cancer - p. 249 236. Growth Hormone Treatment in Children is not Associated with an Increase in the Incidence of Cancer: Experience from KIGS (Pfizer International Growth Database) - p. 250 237. Screening and Surveillance for Second Malignant Neoplasms in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study - p. 251 238. Stillbirth and neonatal death in relation to radiation exposure before conception: a retrospective cohort study - p. 252 239. Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study - p. 253 240. Mobile phone base stations and early childhood cancers: case-control study - p. 254 241. Perinatal Systemic Inflammatory Response Syndrome and Retinopathy of Prematurity - p. 255 242. Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity - p. 256 243. A Higher Incidence of Intermittent Hypoxemic Episodes Is Associated with Severe Retinopathy of Prematurity - p. 257 244. Complications and Visual Prognosis in Children With Aniridia - p. 258 245. Is a 6-Week Course of Ganciclovir Therapy Effective for Chorioretinitis in Infants with Congenital Cytomegalovirus Infection? - p. 259 246. Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies - p. 260 247. Maternal Vitamin A Supplementation and Lung Function in Offspring - p. 261 248. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma - p. 262 249. Smoke-free Legislation and Hospitalizations for Childhood Asthma - p. 263 250. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis - p. 264 251. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis - p. 265 252. Lack of Predictive Value of Tachypnea in the Diagnosis of Pneumonia in Children - p. 266 253. Ambulatory Visit Rates and Antibiotic Prescribing for Children With Pneumonia, 1994–2007 - p. 267 254. Does sweat volume influence the sweat test result? - p. 268 255. Effect of Azithromycin on Pulmonary Function in Patients With Cystic Fibrosis Uninfected With Pseudomonas aeruginosa: A Randomized Controlled Trial - p. 269 256. Infection With Transmissible Strains of Pseudomonas aeruginosa and Clinical Outcomes in Adults With Cystic Fibrosis - p. 270 257. Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation - p. 271 258. The Epidemiology of Prescriptions Abandoned at the Pharmacy - p. 272 259. Malicious Use of Pharmaceuticals in Children - p. 273 260. Evaluation of Consistency in Dosing Directions and Measuring Devices for Pediatric Nonprescription Liquid Medications - p. 274 261. Adverse Events From Cough and Cold Medications After a Market Withdrawal of Products Labeled for Infants - p. 275 262. Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms - p. 276 263. Two Unusual Pediatric Cases of Dilutional Hyponatremia - p. 277 264. HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans - p. 278 265. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids - p. 279 266. A Family-based Randomized Controlled Trial of Pain Intervention for Adolescents With Sickle Cell Disease - p. 280 267. Glowing in the dark: time of day as a determinant of radiographic imaging in the evaluation of abdominal pain in children - p. 281 268. Inflammatory Effects of Phthalates in Neonatal Neutrophils - p. 282 269. Hair Mercury Levels of Women of Reproductive Age in Ontario, Canada: Implications to Fetal Safety and Fish Consumption - p. 283 270. Acute Ethanol Poisoning in a 4-Year-Old as a Result of Ethanol-Based Hand-Sanitizer Ingestion - p. 284 271. Initial Location Determines Spontaneous Passage of Foreign Bodies From the Gastrointestinal Tract in Children - p. 285 272. Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial - p. 286 273. Inhalant Abuse: Monitoring Trends by Using Poison Control Data, 1993–2008 - p. 287 274. Unintentional Child Poisonings Through Ingestion of Conventional and Novel Tobacco Products - p. 288