Year Book of Pulmonary Disease

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. 1. Asthma, Allergy and Cystic Fibrosis - p. 7 5. 1.1. Asthma - p. 8 6. Trends in the age of diagnosis of childhood asthma - p. 9 7. Asthma: pathogenesis and novel drugs for treatment - p. 10 8. New Risk Factors for Adult-Onset Incident Asthma: A Nested Case–Control Study of Host Antioxidant Defense - p. 11 9. Identification of novel immune phenotypes for allergic and nonallergic childhood asthma - p. 12 10. Management of acute loss of asthma control in the yellow zone: A practice parameter - p. 13 11. A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma - p. 15 12. The effect of fluticasone furoate/umeclidinium in adult patients with asthma: A randomized, dose-ranging study - p. 16 13. A randomized, three-period crossover study of umeclidinium as monotherapy in adult patients with asthma - p. 17 14. Cluster Analysis and Characterization of Response to Mepolizumab: A Step Closer to Personalized Medicine for Patients with Severe Asthma - p. 19 15. Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study - p. 20 16. Tiotropium in asthmatic adolescents symptomatic despite inhaled corticosteroids: A randomised dose-ranging study - p. 23 17. Inhaled corticosteroid beliefs, complementary and alternative medicine, and uncontrolled asthma in urban minority adults - p. 24 18. Impact of exhaled nitric oxide measurements on treatment decisions in an asthma specialty clinic - p. 26 19. Linking Patient-Centered Medical Home and Asthma Measures Reduces Hospital Readmission Rates - p. 27 20. Evolution of occupational asthma: Does cessation of exposure really improve prognosis? - p. 28 21. Comparison of US emergency department acute asthma care quality: 1997-2001 and 2011-2012 - p. 29 22. EAACI position paper: irritant-induced asthma - p. 30 23. Rates and Correlates of Relapse Following ED Discharge for Acute Asthma: A Canadian 20-Site Prospective Cohort Study - p. 31 24. Vitamin D, asthma prevalence and asthma exacerbations: a large adult population-based study - p. 32 25. Risk of congenital malformations for asthmatic pregnant women using a long-acting β2-agonist and inhaled corticosteroid combination versus higher-dose inhaled corticosteroid monotherapy - p. 33 26. PRAM Score as Predictor of Pediatric Asthma Hospitalization - p. 34 27. Comparing the Asthma APGAR System and the Asthma Control Test™ in a Multicenter Primary Care Sample - p. 35 28. 1.2. Cystic Fibrosis - p. 36 29. Gene therapy in cystic fibrosis - p. 37 30. Cystic Fibrosis Foundation Pulmonary Guideline: Pharmacologic Approaches to Prevention and Eradication of Initial Pseudomonas aeruginosa Infection - p. 38 31. Viability of Pseudomonas aeruginosa in cough aerosols generated by persons with cystic fibrosis - p. 39 32. Longevity of Patients With Cystic Fibrosis in 2000 to 2010 and Beyond: Survival Analysis of the Cystic Fibrosis Foundation Patient Registry - p. 40 33. Medical and obstetric complications among pregnant women with cystic fibrosis - p. 41 34. 1.3. Miscellaneous - p. 44 35. Scientific Foundations of Allergen-Specific Immunotherapy for Allergic Disease - p. 45 36. 2. Chronic Obstructive Pulmonary Disease - p. 46 37. The association between childhood asthma and adult chronic obstructive pulmonary disease - p. 47 38. Pneumothorax Risk Factors in Smokers with and without Chronic Obstructive Pulmonary Disease - p. 48 39. Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease - p. 49 40. Prognostic evaluation of COPD patients: GOLD 2011 versus BODE and the COPD comorbidity index COTE - p. 50 41. Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD - p. 51 42. The COPD assessment test: a systematic review - p. 52 43. Physical Activity as a Predictor of Thirty-Day Hospital Readmission after a Discharge for a Clinical Exacerbation of Chronic Obstructive Pulmonary Disease - p. 53 44. Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality - p. 54 45. Efficacy and Safety of a Fixed-Dose Combination of Indacaterol and Glycopyrronium for the Treatment of COPD: A Systematic Review - p. 55 46. Combination Long-Acting β-Agonists and Inhaled Corticosteroids Compared With Long-Acting β-Agonists Alone in Older Adults With Chronic Obstructive Pulmonary Disease - p. 56 47. Withdrawal of Inhaled Glucocorticoids and Exacerbations of COPD - p. 57 48. Predictors of Chronic Obstructive Pulmonary Disease Exacerbation Reduction in Response to Daily Azithromycin Therapy - p. 58 49. Benefits of High-Dose N-Acetylcysteine to Exacerbation-Prone Patients With COPD - p. 59 50. Breathlessness, Functional Status, Distress, and Palliative Care Needs Over Time in Patients With Advanced Chronic Obstructive Pulmonary Disease or Lung Cancer: A Cohort Study - p. 60 51. 3. Lung cancer - p. 61 52. 3.1. Epidemiology of Lung Cancer - p. 62 53. Cancer Statistics, 2014 - p. 63 54. Is Previous Respiratory Disease a Risk Factor for Lung Cancer? - p. 64 55. Radiation Risks in Lung Cancer Screening Programs: A Comparison With Nuclear Industry Workers and Atomic Bomb Survivors - p. 65 56. 3.2. Tobacco-related Issues - p. 66 57. Global Effects of Smoking, of Quitting, and of Taxing Tobacco - p. 67 58. Estimation of Cigarette Smoking-Attributable Morbidity in the United States - p. 68 59. Electronic Cigarettes: A Position Statement of the Forum of International Respiratory Societies - p. 69 60. Hidden Formaldehyde in E-Cigarette Aerosols - p. 70 61. 3.3. Lung cancer Screening - p. 71 62. Components Necessary for High Quality Lung Cancer Screening: American College of Chest Physicians and American Thoracic Society Policy Statement - p. 72 63. Cost-Effectiveness of CT Screening in the National Lung Screening Trial - p. 73 64. CT Screening for Lung Cancer: Alternative Definitions of Positive Test Result Based on the National Lung Screening Trial and International Early Lung Cancer Action Program Databases - p. 74 65. Lung Cancer Screening - p. 75 66. Cancer Screening in the United States, 2014: A Review of Current American Cancer Society Guidelines and Current Issues in Cancer Screening - p. 76 67. Chest CT Scan Screening for Lung Cancer in Asbestos Occupational Exposure: A Systematic Review and Meta-analysis - p. 77 68. 3.4. Diagnostic Evaluation - p. 78 69. The Utility of Nodule Volume in the Context of Malignancy Prediction for Small Pulmonary Nodules - p. 79 70. How many names for a rose: Inconsistent classification of multiple foci of lung cancer due to ambiguous rules - p. 80 71. Endobronchial Ultrasound–guided Transbronchial Needle Aspiration for Non–Small Cell Lung Cancer Staging - p. 81 72. Cost effectiveness of endosonography versus surgical staging in potentially resectable lung cancer: a health economics analysis of the ASTER trial from a European perspective - p. 82 73. Accuracy of FDG-PET to Diagnose Lung Cancer in Areas With Infectious Lung Disease: A Meta-analysis - p. 83 74. Assessing the Usefulness of 18F-fluorodeoxyglucose PET-CT Scan After Stereotactic Body Radiotherapy for Early-Stage Non-small Cell Lung Cancer - p. 84 75. 3.5. Lung Cancer Treatment - p. 85 76. Appropriate Sublobar Resection Choice for Ground Glass Opacity-Dominant Clinical Stage IA Lung Adenocarcinoma: Wedge Resection or Segmentectomy - p. 86 77. Sublobar resection is equivalent to lobectomy for clinical stage 1A lung cancer in solid nodules - p. 87 78. 3.6. Molecular Approach to Lung Cancer - p. 88 79. Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Society for the Study of Lung Cancer/Association of Molecular Pathologists Guideline - p. 89 80. Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations - p. 90 81. First-Line Crizotinib versus Chemotherapy in ALK-Positive Lung Cancer - p. 91 82. Ceritinib in ALK-Rearranged Non–Small-Cell Lung Cancer - p. 92 83. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology - p. 93 84. Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs - p. 96 85. 4. Pleural, Interstitial Lung, and Pulmonary Vascular Disease - p. 97 86. 4.1. Interstitial Lung Disease - p. 98 87. Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis - p. 99 88. Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis - p. 100 89. A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis - p. 101 90. Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis - p. 102 91. 4.2. Pleural Disease - p. 103 92. Comparison of Pleural Pressure Measuring Instruments - p. 104 93. Pleural Plaques and Their Effect on Lung Function in Libby Vermiculite Miners - p. 105 94. Comparing Cost of Indwelling Pleural Catheter vs Talc Pleurodesis for Malignant Pleural Effusion - p. 106 95. 4.3. Pulmonary Vascular Disease - p. 107 96. The Right Ventricle Explains Sex Differences in Survival in Idiopathic Pulmonary Arterial Hypertension - p. 108 97. Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults: CHEST Guideline and Expert Panel Report - p. 109 98. Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism - p. 110 99. 5. Community-Acquired Pneumonia - p. 111 100. Rates and Risk Factors for Recurrent Pneumonia in Patients Hospitalized With Community-Acquired Pneumonia: Population-Based Prospective Cohort Study With 5 Years of Follow-up - p. 112 101. Diagnoses of Early and Late Readmissions after Hospitalization for Pneumonia: A Systematic Review - p. 113 102. Characteristics and Outcomes of Patients Hospitalized Following Pulmonary Aspiration - p. 114 103. Predictive Value of Testing Nasopharyngeal Samples for Respiratory Viruses in the Setting of Lower Respiratory Tract Disease - p. 115 104. Lower Respiratory Tract Virus Findings in Mechanically Ventilated Patients With Severe Community-Acquired Pneumonia - p. 116 105. Bacteremia prediction model using a common clinical test in patients with community-acquired pneumonia - p. 117 106. Invasive Pneumococcal Disease After Implementation of 13-Valent Conjugate Vaccine - p. 118 107. Emergence of Hypervirulent Mutants Resistant to Early Clearance During Systemic Serotype 1 Pneumococcal Infection in Mice and Humans - p. 119 108. Association of Azithromycin With Mortality and Cardiovascular Events Among Older Patients Hospitalized With Pneumonia - p. 120 109. Platelet Activation Is Associated With Myocardial Infarction in Patients With Pneumonia - p. 121 110. A 16-Year Prospective Study of Community-Onset Bacteremic Acinetobacter Pneumonia: Low Mortality With Appropriate Initial Empirical Antibiotic Protocols - p. 122 111. Community-acquired lung respiratory infections in HIV-infected patients: microbial aetiology and outcome - p. 123 112. Legionellosis and biologic therapies - p. 124 113. Macrolide/Azalide Therapy for Nodular/Bronchiectatic Mycobacterium Avium Complex Lung Disease - p. 125 114. Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis: a systematic review - p. 126 115. Vaccination Against Staphylococcus aureus Pneumonia - p. 127 116. 6. Lung Transplantation - p. 128 117. Use of the Donor Lung After Asphyxiation or Drowning: Effect on Lung Transplant Recipients - p. 129 118. Assessment of Different Threshold Preoperative Glomerular Filtration Rates as Markers of Outcomes in Lung Transplantation - p. 130 119. Body Mass Index in Lung Transplant Candidates: A Contra-indication to Transplant or Not? - p. 131 120. Pre-transplant donor HLA-specific antibodies: Characteristics causing detrimental effects on survival after lung transplantation - p. 132 121. Genetic Variation in Caveolin-1 Affects Survival After Lung Transplantation - p. 133 122. Characteristics of Patients with Pulmonary Venoocclusive Disease Awaiting Transplantation - p. 134 123. Alemtuzumab in Lung Transplantation: An Open-Label, Randomized, Prospective Single Center Study - p. 135 124. Air Pollution and the Development of Posttransplant Chronic Lung Allograft Dysfunction - p. 136 125. Loss of glucocorticoid receptor from pro-inflammatory T cells after lung transplant - p. 137 126. Azithromycin and the Treatment of Lymphocytic Airway Inflammation After Lung Transplantation - p. 138 127. High CXCL-16 Levels Correlate With Symptomatic Disease in Lung Transplant Recipients With Human Cytomegalovirus Replication in the Allograft - p. 139 128. Characteristics and Outcomes of Patients With Lung Transplantation Requiring Admission to the Medical ICU - p. 140 129. Diverticulitis occurs early after lung transplantation - p. 141 130. Morbidity and Mortality of Live Lung Donation: Results From the RELIVE Study - p. 142 131. 7. Sleep Disorders - p. 143 132. 7.1. Consequences of Sleep-Disordered Breathing - p. 144 133. Obstructive Sleep Apnea and Severe Maternal-Infant Morbidity/Mortality in the United States, 1998-2009 - p. 145 134. Role of Sleep Apnea and Continuous Positive Airway Pressure Therapy in the Incidence of Stroke or Coronary Heart Disease in Women - p. 146 135. Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study - p. 147 136. Diabetes Mellitus Prevalence and Control in Sleep-Disordered Breathing: The European Sleep Apnea Cohort (ESADA) Study - p. 148 137. 7.2. Non-CPAP Treatment of Sleep-Disordered Breathing - p. 149 138. The Complex Sleep Apnea Resolution Study: A Prospective Randomized Controlled Trial of Continuous Positive Airway Pressure Versus Adaptive Servoventilation Therapy - p. 150 139. Tongue Fat and its Relationship to Obstructive Sleep Apnea - p. 151 140. 7.3. Non-Pulmonary Sleep - p. 152 141. Sleep Restriction Therapy for Insomnia is Associated with Reduced Objective Total Sleep Time, Increased Daytime Somnolence, and Objectively Impaired Vigilance: Implications for the Clinical Management of Insomnia Disorder - p. 153 142. Actigraphy-Measured Sleep Disruption as a Predictor of Survival among Women with Advanced Breast Cancer - p. 154 143. Rapid Eye Movement Sleep Behavioral Events: A New Marker for Neurodegeneration in Early Parkinson Disease? - p. 155 144. Insufficient Sleep in Adolescents and Young Adults: An Update on Causes and Consequences - p. 156 145. Subjective and Objective Sleep Disturbance and Longitudinal Risk of Depression in a Cohort of Older Women - p. 157 146. Risk of Sleep Apnea in Hospitalized Older Patients - p. 158 147. A Randomized Controlled Trial of Mindfulness Meditation for Chronic Insomnia - p. 159 148. A Randomized, Double Crossover Study to Investigate the Influence of Saline Infusion on Sleep Apnea Severity in Men - p. 160 149. 7.4. Pediatric Sleep-Disordered Breathing - p. 161 150. Predictors of Obstructive Sleep Apnea Severity in Adenotonsillectomy Candidates - p. 162 151. 8. Critical Care Medicine - p. 163 152. 8.1. Sepsis - p. 164 153. Preparing an ICU room to welcome a critically ill patient with Ebola virus disease - p. 165 154. Diagnostic Characteristics of a Clinical Screening Tool in Combination With Measuring Bedside Lactate Level in Emergency Department Patients With Suspected Sepsis - p. 166 155. Bleeding complications of central venous catheterization in septic patients with abnormal hemostasis - p. 167 156. Cholecystostomy offers no survival benefit in patients with acute acalculous cholecystitis and severe sepsis and shock - p. 168 157. Early intensive care unit-acquired hypernatremia in severe sepsis patients receiving 0.9% saline fluid resuscitation - p. 169 158. Early Management of Severe Sepsis: Concepts and Controversies - p. 170 159. 8.2. Airway - p. 171 160. Angular change in the line of vision to the larynx: implications for determining the laryngoscopic view - p. 172 161. Difficult Airway Management for Novice Physicians: A Randomized Trial Comparing Direct and Video-Assisted Laryngoscopy - p. 173 162. 8.3. Acute Respiratory Disorder Syndrome - p. 174 163. Acute respiratory distress attributed to sirolimus in solid organ transplant recipients - p. 175 164. 8.4. Acute Respiratory Failure - p. 176 165. A 42-Year-Old Farmer From Bangladesh With Respiratory Failure, Septic Arthritis, and Multiple Cavitating Consolidations - p. 177 166. 8.5. Acute Lung Injury - p. 178 167. A Quality Improvement Project Sustainably Decreased Time to Onset of Active Physical Therapy Intervention in Patients with Acute Lung Injury - p. 179 168. 8.6. Trauma - p. 180 169. Association of head, thoracic and abdominal trauma with delayed diagnosis of co-existing injuries in critical trauma patients - p. 181 170. Air Transport of Patients with Pneumothorax: Is Tube Thoracostomy Required Before Flight? - p. 182 171. 8.7. Non Invasive Ventilation - p. 183 172. Efficacy and Safety of Early Dexmedetomidine During Noninvasive Ventilation for Patients with Acute Respiratory Failure: A Randomized, Double-Blind, Placebo-Controlled Pilot Study - p. 184 173. 8.8. Severe Pneumonia - p. 185 174. Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial - p. 186 175. 8.9. Pulmonary Hypertension - p. 187 176. Catheter-Directed Thrombolytic Intervention Is Effective for Patients with Massive and Submassive Pulmonary Embolism - p. 188 177. 8.10. Miscellaneous - p. 189 178. Critical care responsibility in health care reform: What would Osler say? - p. 190 179. Copper removal strategies for Wilson's disease crisis in the ICU - p. 191 180. A randomised controlled trial comparing incentive spirometry with the Acapella® device for physiotherapy after thoracoscopic lung resection surgery - p. 192 181. Characteristics and Outcomes of Patients Admitted to the Acute Palliative Care Unit From the Emergency Center - p. 193 182. A Health System-Based Critical Care Program with a Novel Tele-ICU: Implementation, Cost, and Structure Details - p. 194 183. Dying with Dignity in the Intensive Care Unit - p. 195 184. Brain Death and Islam: The Interface of Religion, Culture, History, Law, and Modern Medicine - p. 196 185. 8.11. Imaging - p. 197 186. Double-lung point sign in traumatic pneumothorax - p. 198