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The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Asthma, Allergy, and Cystic Fibrosis - p. 7 5. Asthma - p. 8 6. Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children - p. 9 7. Adherence rate to beclomethasone dipropionate and the level of asthma control - p. 10 8. Once-daily fluticasone furoate is efficacious in patients with symptomatic asthma on low-dose inhaled corticosteroids - p. 11 9. Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy - p. 12 10. 24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids - p. 13 11. A Systematic Review of Long-Acting β2-Agonists Versus Higher Doses of Inhaled Corticosteroids in Asthma - p. 14 12. Asthma controller delay and recurrence risk after an emergency department visit or hospitalization - p. 15 13. A Cost-Effectiveness Analysis of Inhaled Corticosteroid Delivery for Children with Asthma in the Emergency Department - p. 16 14. Efficacy and safety of fluticasone/formoterol combination therapy in patients with moderate-to-severe asthma - p. 17 15. Status asthmaticus in the medical intensive care unit: A 30-year experience - p. 18 16. Association Between Evidence-Based Standardized Protocols in Emergency Departments With Childhood Asthma Outcomes: A Canadian Population-Based Study - p. 19 17. Cystic Fibrosis - p. 20 18. Personalized Medicine in Cystic Fibrosis: Dawning of a New Era - p. 21 19. Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation - p. 22 20. Role of Cystic Fibrosis Transmembrane Conductance Regulator in Patients With Chronic Sinopulmonary Disease - p. 23 21. Understanding the natural progression in %FEV1 decline in patients with cystic fibrosis: a longitudinal study - p. 24 22. Chronic Obstructive Pulmonary Disease - p. 25 23. Spirometric Predictors of Lung Function Decline and Mortality in Early Chronic Obstructive Pulmonary Disease - p. 26 24. Emphysema Scores Predict Death From COPD and Lung Cancer - p. 27 25. Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease - p. 28 26. Physical Activity Is the Strongest Predictor of All-Cause Mortality in Patients With COPD: A Prospective Cohort Study - p. 29 27. Discussing an uncertain future: end-of-life care conversations in chronic obstructive pulmonary disease. A systematic literature review and narrative synthesis - p. 30 28. Usefulness of the Chronic Obstructive Pulmonary Disease Assessment Test to Evaluate Severity of COPD Exacerbations - p. 31 29. Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease: A Randomized Placebo-Controlled Trial - p. 32 30. Efficacy of Antibiotic Therapy for Acute Exacerbations of Mild to Moderate Chronic Obstructive Pulmonary Disease - p. 33 31. Significance of the microbiome in obstructive lung disease - p. 34 32. Comparison of Indacaterol With Tiotropium or Twice-Daily Long-Acting β-Agonists for Stable COPD: A Systematic Review - p. 35 33. Cognitive dysfunction in patients with chronic obstructive pulmonary disease – A systematic review - p. 36 34. Venous Thromboembolism in Patients with Chronic Obstructive Pulmonary Disease - p. 37 35. The Impact of COPD on Management and Outcomes of Patients Hospitalized With Acute Myocardial Infarction: A 10-Year Retrospective Observational Study - p. 38 36. Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease - p. 39 37. Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults - p. 40 38. Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction - p. 41 39. Lung Cancer - p. 42 40. Epidemiology of Lung Cancer - p. 43 41. Cancer Statistics, 2012 - p. 44 42. Increasing Lung Cancer Death Rates Among Young Women in Southern and Midwestern States - p. 45 43. Lung Cancer Incidence and Mortality Among HIV-Infected and HIV-Uninfected Injection Drug Users - p. 46 44. Tobacco-Related Issues - p. 47 45. Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis - p. 48 46. Short-term Pulmonary Effects of Using an Electronic Cigarette: Impact on Respiratory Flow Resistance, Impedance, and Exhaled Nitric Oxide - p. 49 47. An Unexpected Consequence of Electronic Cigarette Use - p. 50 48. A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation - p. 51 49. Lung Cancer Screening - p. 52 50. Benefits and Harms of CT Screening for Lung Cancer: A Systematic Review - p. 53 51. When the Average Applies to No One: Personalized Decision Making About Potential Benefits of Lung Cancer Screening - p. 55 52. Lung Cancer Screening - p. 56 53. Predicting and managing the risk of pulmonary haemorrhage in patients with NSCLC treated with bevacizumab: a consensus report from a panel of experts - p. 57 54. Lung Cancer Risk Prediction: Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Models and Validation - p. 58 55. Predictive Accuracy of the Liverpool Lung Project Risk Model for Stratifying Patients for Computed Tomography Screening for Lung Cancer: A Case–Control and Cohort Validation Study - p. 59 56. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT - p. 60 57. Diagnostic Evaluation - p. 61 58. Estimating Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer: A Cohort Study - p. 62 59. Lung cancer detection by canine scent: will there be a lab in the lab? - p. 63 60. Exhaled Breath Analysis with a Colorimetric Sensor Array for the Identification and Characterization of Lung Cancer - p. 64 61. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon - p. 65 62. Lung Cancer Treatment - p. 66 63. Cancer Treatment and Survivorship Statistics, 2012 - p. 67 64. Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer - p. 68 65. Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer - p. 69 66. Patients’ Expectations about Effects of Chemotherapy for Advanced Cancer - p. 70 67. Lobectomy in Octogenarians With Non-Small Cell Lung Cancer: Ramifications of Increasing Life Expectancy and the Benefits of Minimally Invasive Surgery - p. 71 68. Molecular Approach to Lung Cancer - p. 72 69. ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers - p. 73 70. Epigenetic Control of Gene Expression in the Lung - p. 74 71. Pleural, Interstitial Lung, and Pulmonary Vascular Disease - p. 75 72. Interstitial Lung Disease - p. 76 73. Predicting survival in newly diagnosed idiopathic pulmonary fibrosis: a 3-year prospective study - p. 77 74. Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis - p. 78 75. Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy - p. 79 76. Pleural Disease - p. 80 77. Outcome of patients diagnosed with fibrinous pleuritis after medical thoracoscopy - p. 81 78. Effect of an Indwelling Pleural Catheter vs Chest Tube and Talc Pleurodesis for Relieving Dyspnea in Patients With Malignant Pleural Effusion: The TIME2 Randomized Controlled Trial - p. 82 79. Treatment of Malignant Pleural Effusion: A Cost-Effectiveness Analysis - p. 83 80. Pulmonary Vascular Disease - p. 84 81. Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial - p. 85 82. Peripheral Extracorporeal Membrane Oxygenation: Comprehensive Therapy for High-Risk Massive Pulmonary Embolism - p. 86 83. Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room - p. 87 84. Usefulness of Preemptive Anticoagulation in Patients With Suspected Pulmonary Embolism: A Decision Analysis - p. 88 85. Longitudinal Analysis Casts Doubt on the Presence of Genetic Anticipation in Heritable Pulmonary Arterial Hypertension - p. 89 86. Effects of Commercial Air Travel on Patients With Pulmonary Hypertension - p. 90 87. Safety and efficacy of exercise training in various forms of pulmonary hypertension - p. 91 88. The Minimal Important Difference in the 6-Minute Walk Test for Patients with Pulmonary Arterial Hypertension - p. 92 89. Atorvastatin in Pulmonary Arterial Hypertension (APATH) study - p. 93 90. Bloodstream Infections in Patients With Pulmonary Arterial Hypertension Treated With Intravenous Prostanoids: Insights From the REVEAL REGISTRY® - p. 94 91. Tadalafil for the Treatment of Pulmonary Arterial Hypertension: A Double-Blind 52-Week Uncontrolled Extension Study - p. 95 92. Effectiveness and Safety of Inhaled Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Children - p. 96 93. Baseline characteristics and follow-up in patients with normal haemodynamics versus borderline mean pulmonary arterial pressure in systemic sclerosis: results from the PHAROS registry - p. 97 94. An Evaluation of Long-term Survival From Time of Diagnosis in Pulmonary Arterial Hypertension From the REVEAL Registry - p. 98 95. Community-Acquired Pneumonia - p. 99 96. Aging Population and Future Burden of Pneumococcal Pneumonia in the United States - p. 100 97. Pneumonia and pregnancy outcomes: a nationwide population-based study - p. 101 98. Association of Diagnostic Coding With Trends in Hospitalizations and Mortality of Patients With Pneumonia, 2003-2009 - p. 102 99. Influenza-Associated Pneumonia Among Hospitalized Patients With 2009 Pandemic Influenza A (H1N1) Virus—United States, 2009 - p. 103 100. The natural history of community-acquired pneumonia in COPD patients: A population database analysis - p. 104 101. Direct Comparison of Three Natriuretic Peptides for Prediction of Short- and Long-term Mortality in Patients With Community-Acquired Pneumonia - p. 105 102. Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study - p. 106 103. Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis - p. 107 104. Predictive factors, microbiology and outcome of patients with parapneumonic effusion - p. 108 105. Prevalence of Methicillin-Resistant Staphylococcus aureus as an Etiology of Community-Acquired Pneumonia - p. 109 106. Predictors of In-Hospital vs Postdischarge Mortality in Pneumonia - p. 110 107. Macrolide-Based Regimens and Mortality in Hospitalized Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis - p. 111 108. Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia: A Randomized Trial - p. 112 109. Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis - p. 113 110. Effect of a 3-Step Critical Pathway to Reduce Duration of Intravenous Antibiotic Therapy and Length of Stay in Community-Acquired Pneumonia: A Randomized Controlled Trial - p. 114 111. Lung Transplantation - p. 115 112. Clinical Ex Vivo Lung Perfusion–Pushing the Limits - p. 116 113. Excellent Clinical Outcomes From a National Donation-After-Determination-of-Cardiac-Death Lung Transplant Collaborative - p. 117 114. Outcome of critically ill lung transplant candidates on invasive respiratory support - p. 118 115. Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry - p. 119 116. Hypoalbuminemia and Early Mortality After Lung Transplantation: A Cohort Study - p. 120 117. Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation - p. 121 118. Cavitatory lung disease in thoracic transplant recipients receiving sirolimus - p. 122 119. SaLUTaRy: Survey of lung transplant rejection - p. 123 120. A Targeted Peritransplant Antifungal Strategy for the Prevention of Invasive Fungal Disease After Lung Transplantation: A Sequential Cohort Analysis - p. 124 121. Exercise Training After Lung Transplantation Improves Participation in Daily Activity: A Randomized Controlled Trial - p. 125 122. Changes in Neurocognitive Functioning Following Lung Transplantation - p. 126 123. Risk of Post-Lung Transplant Renal Dysfunction in Adults With Cystic Fibrosis - p. 127 124. Survival and Extrapulmonary Course of Connective Tissue Disease After Lung Transplantation - p. 128 125. Sleep disorders - p. 129 126. Central Sleep Apnea and Heart Failure - p. 130 127. The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses - p. 131 128. Consequences of Sleep-Disordered Breathing - p. 132 129. Obstructive Sleep Apnea Affects Hospital Outcomes of Patients with non-ST-Elevation Acute Coronary Syndromes - p. 133 130. Obstructive sleep apnea and the risk of adverse pregnancy outcomes - p. 134 131. A 3-year longitudinal study of sleep disordered breathing in the elderly - p. 135 132. Cardiovascular Mortality in Obstructive Sleep Apnea in the Elderly: Role of Long-Term Continuous Positive Airway Pressure Treatment: A Prospective Observational Study - p. 136 133. Sleep-disordered Breathing and Cancer Mortality: Results from the Wisconsin Sleep Cohort Study - p. 137 134. CPAP Treatment and Benefits - p. 138 135. Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension - p. 139 136. Obstructive Sleep Apnea: Effects of Continuous Positive Airway Pressure on Cardiac Remodeling as Assessed by Cardiac Biomarkers, Echocardiography and Cardiac MRI - p. 140 137. Control of OSA During Automatic Positive Airway Pressure Titration in a Clinical Case Series: Predictors and Accuracy of Device Download Data - p. 141 138. Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea: A Randomized Controlled Trial - p. 142 139. Continuous Positive Airway Pressure Treatment of Sleepy Patients with Milder Obstructive Sleep Apnea: Results of the CPAP Apnea Trial North American Program (CATNAP) Randomized Clinical Trial - p. 143 140. Non-CPAP Treatment of Sleep-Disordered Breathing - p. 144 141. Exercise Is Associated with a Reduced Incidence of Sleep-disordered Breathing - p. 145 142. Long-term follow-up of patients operated with Uvulopalatopharyngoplasty from 1985 to 1991 - p. 146 143. Acute Upper Airway Responses to Hypoglossal Nerve Stimulation during Sleep in Obstructive Sleep Apnea - p. 147 144. Surgical vs Conventional Therapy for Weight Loss Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial - p. 148 145. Non-Pulmonary Sleep - p. 149 146. Association of Insomnia and Short Sleep Duration With Atherosclerosis Risk in the Elderly - p. 150 147. Sleep Disturbances Among Soldiers with Combat-Related Traumatic Brain Injury - p. 151 148. Sleep Disruption Due to Hospital Noises: A Prospective Evaluation - p. 152 149. Self-Reported Sleep Characteristics and Mortality in Older Adults of Mexican Origin: Results From the Hispanic Established Population for the Epidemiologic Study of the Elderly - p. 153 150. Pediatric Sleep-Disordered Breathing - p. 154 151. Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome - p. 155 152. Critical Care Medicine - p. 156 153. Acute Respiratory Disorder Syndrome - p. 157 154. Venovenous Extracorporeal Membrane Oxygenation in Adults: Practical Aspects of Circuits, Cannulae, and Procedures - p. 158 155. Pharmacotherapy for Acute Respiratory Distress Syndrome - p. 160 156. The acute respiratory distress syndrome - p. 161 157. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material - p. 162 158. Trauma Issues - p. 163 159. A model for predicting primary blast lung injury - p. 164 160. Acute Respiratory Failure - p. 165 161. A comparison of immunomodulation therapies in mechanically ventilated patients with Guillain Barré syndrome - p. 166 162. Airway Management - p. 167 163. Complications and failure of airway management - p. 168 164. Ventilator-Associated Pneumonia - p. 169 165. Clinical predictors of Pseudomonas aeruginosa or Acinetobacter baumannii bacteremia in patients admitted to the ED - p. 170 166. Decreasing ventilator-associated pneumonia in the intensive care unit: A sustainable comprehensive quality improvement program - p. 171 167. Pulmonary Hypertension in the ICU - p. 172 168. Aggressive Surgical Treatment of Acute Pulmonary Embolism With Circulatory Collapse - p. 173 169. A Primary Pulmonary Artery Chondrosarcoma Manifesting as Acute Pulmonary Embolism - p. 174 170. World Health Organization Pulmonary Hypertension Group 2: Pulmonary hypertension due to left heart disease in the adult—a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation - p. 175 171. Imaging and Monitoring in the ICU - p. 176 172. Effect of Bedside Ultrasonography on the Certainty of Physician Clinical Decisionmaking for Septic Patients in the Emergency Department - p. 177 173. Accuracy of non-invasive measurement of haemoglobin concentration by pulse co-oximetry during steady-state and dynamic conditions in liver surgery - p. 178 174. Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters - p. 179 175. A 61-year-old man with cough and abnormal chest x-ray - p. 180 176. A National ICU Telemedicine Survey: Validation and Results - p. 181 177. A potentially hazardous complication during central venous catheterization: lost guidewire retained in the patient - p. 182 178. Miscellaneous - p. 183 179. Acquired Neuromuscular Weakness and Early Mobilization in the Intensive Care Unit - p. 184 180. Adverse events are common on the intensive care unit: results from a structured record review - p. 185 181. A Historical Perspective on Sepsis - p. 186 182. A 42-year-old woman with septic shock: an unexpected source - p. 187 183. A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis - p. 188 184. A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors - p. 189 185. Recurrent Sepsis in a 69-Year-Old Woman - p. 190 186. Clinical characteristics and outcomes of obstetric patients admitted to the intensive care unit - p. 191

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The Year Book of Pulmonary Disease brings you abstracts of the articles that reported the year's breakthrough developments in pulmonary disease carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Asthma and Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Lung Cancer, Community-Acquired Pneumonia, Lung Transplantation, Sleep Disorders, and Critical Care Medicine are represented highlighting the most current and relevant articles in the field.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Asthma, Allergy, and Cystic Fibrosis - p. 7 5. Asthma - p. 8 6. Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children - p. 9 7. Adherence rate to beclomethasone dipropionate and the level of asthma control - p. 10 8. Once-daily fluticasone furoate is efficacious in patients with symptomatic asthma on low-dose inhaled corticosteroids - p. 11 9. Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy - p. 12 10. 24-h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids - p. 13 11. A Systematic Review of Long-Acting β2-Agonists Versus Higher Doses of Inhaled Corticosteroids in Asthma - p. 14 12. Asthma controller delay and recurrence risk after an emergency department visit or hospitalization - p. 15 13. A Cost-Effectiveness Analysis of Inhaled Corticosteroid Delivery for Children with Asthma in the Emergency Department - p. 16 14. Efficacy and safety of fluticasone/formoterol combination therapy in patients with moderate-to-severe asthma - p. 17 15. Status asthmaticus in the medical intensive care unit: A 30-year experience - p. 18 16. Association Between Evidence-Based Standardized Protocols in Emergency Departments With Childhood Asthma Outcomes: A Canadian Population-Based Study - p. 19 17. Cystic Fibrosis - p. 20 18. Personalized Medicine in Cystic Fibrosis: Dawning of a New Era - p. 21 19. Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation - p. 22 20. Role of Cystic Fibrosis Transmembrane Conductance Regulator in Patients With Chronic Sinopulmonary Disease - p. 23 21. Understanding the natural progression in %FEV1 decline in patients with cystic fibrosis: a longitudinal study - p. 24 22. Chronic Obstructive Pulmonary Disease - p. 25 23. Spirometric Predictors of Lung Function Decline and Mortality in Early Chronic Obstructive Pulmonary Disease - p. 26 24. Emphysema Scores Predict Death From COPD and Lung Cancer - p. 27 25. Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease - p. 28 26. Physical Activity Is the Strongest Predictor of All-Cause Mortality in Patients With COPD: A Prospective Cohort Study - p. 29 27. Discussing an uncertain future: end-of-life care conversations in chronic obstructive pulmonary disease. A systematic literature review and narrative synthesis - p. 30 28. Usefulness of the Chronic Obstructive Pulmonary Disease Assessment Test to Evaluate Severity of COPD Exacerbations - p. 31 29. Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease: A Randomized Placebo-Controlled Trial - p. 32 30. Efficacy of Antibiotic Therapy for Acute Exacerbations of Mild to Moderate Chronic Obstructive Pulmonary Disease - p. 33 31. Significance of the microbiome in obstructive lung disease - p. 34 32. Comparison of Indacaterol With Tiotropium or Twice-Daily Long-Acting β-Agonists for Stable COPD: A Systematic Review - p. 35 33. Cognitive dysfunction in patients with chronic obstructive pulmonary disease – A systematic review - p. 36 34. Venous Thromboembolism in Patients with Chronic Obstructive Pulmonary Disease - p. 37 35. The Impact of COPD on Management and Outcomes of Patients Hospitalized With Acute Myocardial Infarction: A 10-Year Retrospective Observational Study - p. 38 36. Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease - p. 39 37. Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults - p. 40 38. Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction - p. 41 39. Lung Cancer - p. 42 40. Epidemiology of Lung Cancer - p. 43 41. Cancer Statistics, 2012 - p. 44 42. Increasing Lung Cancer Death Rates Among Young Women in Southern and Midwestern States - p. 45 43. Lung Cancer Incidence and Mortality Among HIV-Infected and HIV-Uninfected Injection Drug Users - p. 46 44. Tobacco-Related Issues - p. 47 45. Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis - p. 48 46. Short-term Pulmonary Effects of Using an Electronic Cigarette: Impact on Respiratory Flow Resistance, Impedance, and Exhaled Nitric Oxide - p. 49 47. An Unexpected Consequence of Electronic Cigarette Use - p. 50 48. A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation - p. 51 49. Lung Cancer Screening - p. 52 50. Benefits and Harms of CT Screening for Lung Cancer: A Systematic Review - p. 53 51. When the Average Applies to No One: Personalized Decision Making About Potential Benefits of Lung Cancer Screening - p. 55 52. Lung Cancer Screening - p. 56 53. Predicting and managing the risk of pulmonary haemorrhage in patients with NSCLC treated with bevacizumab: a consensus report from a panel of experts - p. 57 54. Lung Cancer Risk Prediction: Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Models and Validation - p. 58 55. Predictive Accuracy of the Liverpool Lung Project Risk Model for Stratifying Patients for Computed Tomography Screening for Lung Cancer: A Case–Control and Cohort Validation Study - p. 59 56. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT - p. 60 57. Diagnostic Evaluation - p. 61 58. Estimating Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer: A Cohort Study - p. 62 59. Lung cancer detection by canine scent: will there be a lab in the lab? - p. 63 60. Exhaled Breath Analysis with a Colorimetric Sensor Array for the Identification and Characterization of Lung Cancer - p. 64 61. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon - p. 65 62. Lung Cancer Treatment - p. 66 63. Cancer Treatment and Survivorship Statistics, 2012 - p. 67 64. Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer - p. 68 65. Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer - p. 69 66. Patients’ Expectations about Effects of Chemotherapy for Advanced Cancer - p. 70 67. Lobectomy in Octogenarians With Non-Small Cell Lung Cancer: Ramifications of Increasing Life Expectancy and the Benefits of Minimally Invasive Surgery - p. 71 68. Molecular Approach to Lung Cancer - p. 72 69. ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers - p. 73 70. Epigenetic Control of Gene Expression in the Lung - p. 74 71. Pleural, Interstitial Lung, and Pulmonary Vascular Disease - p. 75 72. Interstitial Lung Disease - p. 76 73. Predicting survival in newly diagnosed idiopathic pulmonary fibrosis: a 3-year prospective study - p. 77 74. Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis - p. 78 75. Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy - p. 79 76. Pleural Disease - p. 80 77. Outcome of patients diagnosed with fibrinous pleuritis after medical thoracoscopy - p. 81 78. Effect of an Indwelling Pleural Catheter vs Chest Tube and Talc Pleurodesis for Relieving Dyspnea in Patients With Malignant Pleural Effusion: The TIME2 Randomized Controlled Trial - p. 82 79. Treatment of Malignant Pleural Effusion: A Cost-Effectiveness Analysis - p. 83 80. Pulmonary Vascular Disease - p. 84 81. Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial - p. 85 82. Peripheral Extracorporeal Membrane Oxygenation: Comprehensive Therapy for High-Risk Massive Pulmonary Embolism - p. 86 83. Ordering CT pulmonary angiography to exclude pulmonary embolism: defense versus evidence in the emergency room - p. 87 84. Usefulness of Preemptive Anticoagulation in Patients With Suspected Pulmonary Embolism: A Decision Analysis - p. 88 85. Longitudinal Analysis Casts Doubt on the Presence of Genetic Anticipation in Heritable Pulmonary Arterial Hypertension - p. 89 86. Effects of Commercial Air Travel on Patients With Pulmonary Hypertension - p. 90 87. Safety and efficacy of exercise training in various forms of pulmonary hypertension - p. 91 88. The Minimal Important Difference in the 6-Minute Walk Test for Patients with Pulmonary Arterial Hypertension - p. 92 89. Atorvastatin in Pulmonary Arterial Hypertension (APATH) study - p. 93 90. Bloodstream Infections in Patients With Pulmonary Arterial Hypertension Treated With Intravenous Prostanoids: Insights From the REVEAL REGISTRY® - p. 94 91. Tadalafil for the Treatment of Pulmonary Arterial Hypertension: A Double-Blind 52-Week Uncontrolled Extension Study - p. 95 92. Effectiveness and Safety of Inhaled Treprostinil for the Treatment of Pulmonary Arterial Hypertension in Children - p. 96 93. Baseline characteristics and follow-up in patients with normal haemodynamics versus borderline mean pulmonary arterial pressure in systemic sclerosis: results from the PHAROS registry - p. 97 94. An Evaluation of Long-term Survival From Time of Diagnosis in Pulmonary Arterial Hypertension From the REVEAL Registry - p. 98 95. Community-Acquired Pneumonia - p. 99 96. Aging Population and Future Burden of Pneumococcal Pneumonia in the United States - p. 100 97. Pneumonia and pregnancy outcomes: a nationwide population-based study - p. 101 98. Association of Diagnostic Coding With Trends in Hospitalizations and Mortality of Patients With Pneumonia, 2003-2009 - p. 102 99. Influenza-Associated Pneumonia Among Hospitalized Patients With 2009 Pandemic Influenza A (H1N1) Virus—United States, 2009 - p. 103 100. The natural history of community-acquired pneumonia in COPD patients: A population database analysis - p. 104 101. Direct Comparison of Three Natriuretic Peptides for Prediction of Short- and Long-term Mortality in Patients With Community-Acquired Pneumonia - p. 105 102. Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study - p. 106 103. Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis - p. 107 104. Predictive factors, microbiology and outcome of patients with parapneumonic effusion - p. 108 105. Prevalence of Methicillin-Resistant Staphylococcus aureus as an Etiology of Community-Acquired Pneumonia - p. 109 106. Predictors of In-Hospital vs Postdischarge Mortality in Pneumonia - p. 110 107. Macrolide-Based Regimens and Mortality in Hospitalized Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis - p. 111 108. Recombinant Tissue Factor Pathway Inhibitor in Severe Community-acquired Pneumonia: A Randomized Trial - p. 112 109. Risk of pneumonia associated with use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers: systematic review and meta-analysis - p. 113 110. Effect of a 3-Step Critical Pathway to Reduce Duration of Intravenous Antibiotic Therapy and Length of Stay in Community-Acquired Pneumonia: A Randomized Controlled Trial - p. 114 111. Lung Transplantation - p. 115 112. Clinical Ex Vivo Lung Perfusion–Pushing the Limits - p. 116 113. Excellent Clinical Outcomes From a National Donation-After-Determination-of-Cardiac-Death Lung Transplant Collaborative - p. 117 114. Outcome of critically ill lung transplant candidates on invasive respiratory support - p. 118 115. Effect of donor smoking on survival after lung transplantation: a cohort study of a prospective registry - p. 119 116. Hypoalbuminemia and Early Mortality After Lung Transplantation: A Cohort Study - p. 120 117. Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: Results of a prospective, randomized international trial in lung transplantation - p. 121 118. Cavitatory lung disease in thoracic transplant recipients receiving sirolimus - p. 122 119. SaLUTaRy: Survey of lung transplant rejection - p. 123 120. A Targeted Peritransplant Antifungal Strategy for the Prevention of Invasive Fungal Disease After Lung Transplantation: A Sequential Cohort Analysis - p. 124 121. Exercise Training After Lung Transplantation Improves Participation in Daily Activity: A Randomized Controlled Trial - p. 125 122. Changes in Neurocognitive Functioning Following Lung Transplantation - p. 126 123. Risk of Post-Lung Transplant Renal Dysfunction in Adults With Cystic Fibrosis - p. 127 124. Survival and Extrapulmonary Course of Connective Tissue Disease After Lung Transplantation - p. 128 125. Sleep disorders - p. 129 126. Central Sleep Apnea and Heart Failure - p. 130 127. The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses - p. 131 128. Consequences of Sleep-Disordered Breathing - p. 132 129. Obstructive Sleep Apnea Affects Hospital Outcomes of Patients with non-ST-Elevation Acute Coronary Syndromes - p. 133 130. Obstructive sleep apnea and the risk of adverse pregnancy outcomes - p. 134 131. A 3-year longitudinal study of sleep disordered breathing in the elderly - p. 135 132. Cardiovascular Mortality in Obstructive Sleep Apnea in the Elderly: Role of Long-Term Continuous Positive Airway Pressure Treatment: A Prospective Observational Study - p. 136 133. Sleep-disordered Breathing and Cancer Mortality: Results from the Wisconsin Sleep Cohort Study - p. 137 134. CPAP Treatment and Benefits - p. 138 135. Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension - p. 139 136. Obstructive Sleep Apnea: Effects of Continuous Positive Airway Pressure on Cardiac Remodeling as Assessed by Cardiac Biomarkers, Echocardiography and Cardiac MRI - p. 140 137. Control of OSA During Automatic Positive Airway Pressure Titration in a Clinical Case Series: Predictors and Accuracy of Device Download Data - p. 141 138. Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea: A Randomized Controlled Trial - p. 142 139. Continuous Positive Airway Pressure Treatment of Sleepy Patients with Milder Obstructive Sleep Apnea: Results of the CPAP Apnea Trial North American Program (CATNAP) Randomized Clinical Trial - p. 143 140. Non-CPAP Treatment of Sleep-Disordered Breathing - p. 144 141. Exercise Is Associated with a Reduced Incidence of Sleep-disordered Breathing - p. 145 142. Long-term follow-up of patients operated with Uvulopalatopharyngoplasty from 1985 to 1991 - p. 146 143. Acute Upper Airway Responses to Hypoglossal Nerve Stimulation during Sleep in Obstructive Sleep Apnea - p. 147 144. Surgical vs Conventional Therapy for Weight Loss Treatment of Obstructive Sleep Apnea: A Randomized Controlled Trial - p. 148 145. Non-Pulmonary Sleep - p. 149 146. Association of Insomnia and Short Sleep Duration With Atherosclerosis Risk in the Elderly - p. 150 147. Sleep Disturbances Among Soldiers with Combat-Related Traumatic Brain Injury - p. 151 148. Sleep Disruption Due to Hospital Noises: A Prospective Evaluation - p. 152 149. Self-Reported Sleep Characteristics and Mortality in Older Adults of Mexican Origin: Results From the Hispanic Established Population for the Epidemiologic Study of the Elderly - p. 153 150. Pediatric Sleep-Disordered Breathing - p. 154 151. Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome - p. 155 152. Critical Care Medicine - p. 156 153. Acute Respiratory Disorder Syndrome - p. 157 154. Venovenous Extracorporeal Membrane Oxygenation in Adults: Practical Aspects of Circuits, Cannulae, and Procedures - p. 158 155. Pharmacotherapy for Acute Respiratory Distress Syndrome - p. 160 156. The acute respiratory distress syndrome - p. 161 157. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material - p. 162 158. Trauma Issues - p. 163 159. A model for predicting primary blast lung injury - p. 164 160. Acute Respiratory Failure - p. 165 161. A comparison of immunomodulation therapies in mechanically ventilated patients with Guillain Barré syndrome - p. 166 162. Airway Management - p. 167 163. Complications and failure of airway management - p. 168 164. Ventilator-Associated Pneumonia - p. 169 165. Clinical predictors of Pseudomonas aeruginosa or Acinetobacter baumannii bacteremia in patients admitted to the ED - p. 170 166. Decreasing ventilator-associated pneumonia in the intensive care unit: A sustainable comprehensive quality improvement program - p. 171 167. Pulmonary Hypertension in the ICU - p. 172 168. Aggressive Surgical Treatment of Acute Pulmonary Embolism With Circulatory Collapse - p. 173 169. A Primary Pulmonary Artery Chondrosarcoma Manifesting as Acute Pulmonary Embolism - p. 174 170. World Health Organization Pulmonary Hypertension Group 2: Pulmonary hypertension due to left heart disease in the adult—a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation - p. 175 171. Imaging and Monitoring in the ICU - p. 176 172. Effect of Bedside Ultrasonography on the Certainty of Physician Clinical Decisionmaking for Septic Patients in the Emergency Department - p. 177 173. Accuracy of non-invasive measurement of haemoglobin concentration by pulse co-oximetry during steady-state and dynamic conditions in liver surgery - p. 178 174. Decrease in central venous catheter placement due to use of ultrasound guidance for peripheral intravenous catheters - p. 179 175. A 61-year-old man with cough and abnormal chest x-ray - p. 180 176. A National ICU Telemedicine Survey: Validation and Results - p. 181 177. A potentially hazardous complication during central venous catheterization: lost guidewire retained in the patient - p. 182 178. Miscellaneous - p. 183 179. Acquired Neuromuscular Weakness and Early Mobilization in the Intensive Care Unit - p. 184 180. Adverse events are common on the intensive care unit: results from a structured record review - p. 185 181. A Historical Perspective on Sepsis - p. 186 182. A 42-year-old woman with septic shock: an unexpected source - p. 187 183. A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis - p. 188 184. A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors - p. 189 185. Recurrent Sepsis in a 69-Year-Old Woman - p. 190 186. Clinical characteristics and outcomes of obstetric patients admitted to the intensive care unit - p. 191

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