Year Book of Surgery 2014

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. 1. General Considerations - p. 10 5. General Surgery Residency Inadequately Prepares Trainees for Fellowship: Results of a Survey of Fellowship Program Directors - p. 11 6. Characteristics of Highly Ranked Applicants to General Surgery Residency Programs - p. 12 7. Accelerating Physician Workforce Transformation Through Competitive Graduate Medical Education Funding - p. 13 8. The Residency Mismatch - p. 14 9. Projecting Surgeon Supply Using a Dynamic Model - p. 15 10. Pilot Testing of a Model for Insurer-Driven, Large-Scale Multicenter Simulation Training for Operating Room Teams - p. 16 11. The Value of Sharing Treatment Decision Making With Patients: Expecting Too Much? - p. 17 12. Impact of Medical Malpractice Environment on Surgical Quality and Outcomes - p. 18 13. It's Big Surgery: Preoperative Expressions of Risk, Responsibility, and Commitment to Treatment After High-Risk Operations - p. 19 14. Bridging the Gap from T to K: Integrated Surgical Research Fellowship for the Next Generation of Surgical Scientists - p. 20 15. Comparison of Registered and Published Primary Outcomes in Randomized Clinical Trials of Surgical Interventions - p. 21 16. The randomized registry trial–the next disruptive technology in clinical research? - p. 22 17. Black patients more likely than whites to undergo surgery at low-quality hospitals in segregated regions - p. 23 18. Distributions of Industry Payments to Massachusetts Physicians - p. 24 19. An Interactive Individualized Intervention to Promote Behavioral Change to Increase Personal Well-Being in US Surgeons - p. 25 20. 2. Trauma - p. 26 21. Laparoscopic radiofrequency ablation for traumatic splenic rupture - p. 27 22. Clinical Outcome After Vertebral Artery Injury Following Blunt Cervical Spine Trauma - p. 28 23. Triage of Elderly Trauma Patients: A Population-Based Perspective - p. 29 24. Analysis of remote trauma transfers in South Central Texas with comparison with current US combat operations: Results of the RemTORN-I study - p. 30 25. Influencing Medical Student Education Via a Voluntary Shadowing Program for Trauma and Acute Care Surgery - p. 31 26. Prospective Evaluation of the Role of Computed Tomography in the Assessment of Abdominal Stab Wounds - p. 32 27. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy - p. 33 28. Regional collaboration across hospital systems to develop and implement trauma protocols saves lives within 2 years - p. 34 29. The injured elderly: A rising tide - p. 35 30. Flow disruptions in trauma care handoffs - p. 36 31. A comparison of health outcomes for combat amputee and limb salvage patients injured in Iraq and Afghanistan wars - p. 37 32. Outcomes after colon trauma in the 21st century: An analysis of the U.S. National Trauma Data Bank - p. 38 33. Bilateral lower-extremity amputation wounds are associated with distinct local and systemic cytokine response - p. 39 34. Mechanism of injury alone is not justified as the sole indication for computed tomographic imaging in blunt pediatric trauma - p. 40 35. Vasopressor use after initial damage control laparotomy increases risk for anastomotic disruption in the management of destructive colon injuries - p. 41 36. A Paradigm Shift in Trauma Resuscitation: Evaluation of Evolving Massive Transfusion Practices - p. 42 37. Excessively Long Hospital Stays After Trauma Are Not Related to the Severity of Illness: Let's Aim to the Right Target! - p. 43 38. Blunt cerebrovascular injury in children: Underreported or underrecognized?: A multicenter ATOMAC study - p. 44 39. 3. Burns - p. 45 40. A Protocol of Early Aggressive Acceleration of Tube Feeding Increases Ileus Without Perceptible Benefit in Severely Burned Patients - p. 46 41. Time to Rehabilitation in the Burn Population: Incidence of Zero Onset Days in the UDSmr National Dataset - p. 47 42. Treatment of Patients With Severe Burns—Costs and Health-Related Quality of Life Outcome - p. 48 43. Doxycycline attenuates burn-induced microvascular hyperpermeability - p. 49 44. Burn-Induced Cardiac Dysfunction Increases Length of Stay in Pediatric Burn Patients - p. 50 45. Admission Temperature and Survival in Patients Admitted to Burn Centers - p. 51 46. Acute burn induced coagulopathy - p. 52 47. Evaluation of an Enoxaparin Dosing Calculator Using Burn Size and Weight - p. 53 48. Noninvasive Measurement of Intestinal Inflammation After Burn Injury - p. 54 49. Fluid Therapy LiDCO Controlled Trial—Optimization of Volume Resuscitation of Extensively Burned Patients through Noninvasive Continuous Real-Time Hemodynamic Monitoring LiDCO - p. 55 50. A randomized comparison study of Aquacel Ag and Alginate Silver as skin graft donor site dressings - p. 56 51. A comparative study of 1% silver sulphadiazine (Flammazine®) versus an enzyme alginogel (Flaminal®) in the treatment of partial thickness burns - p. 57 52. Antimicrobial efficacy of a novel silver hydrogel dressing compared to two common silver burn wound dressings: Acticoat™ and PolyMem Silver® - p. 58 53. Efficacy of debridement and wound cleansing with 2% hydrogen peroxide on graft take in the chronic-colonized burn wounds; a randomized controlled clinical trial - p. 59 54. 4. Critical Care - p. 60 55. Executive Summary: Developing a New, National Approach to Surveillance for Ventilator-associated Events - p. 61 56. The impact of intensivists' base specialty of training on care process and outcomes of critically ill trauma patients - p. 62 57. Obesity and overweight as a risk factor for pneumonia in polytrauma patients: A retrospective cohort study - p. 63 58. Innovations in geriatric trauma and resident research education: bridging the gap - p. 64 59. Characterizing vasopressin and other vasoactive mediators released during resuscitation of trauma patients - p. 65 60. Predicting the need for urgent intubation in a surgical/trauma intensive care unit - p. 66 61. Mild Obesity Is Protective After Severe Burn Injury - p. 67 62. The Frequency and Cost of Treatment Perceived to Be Futile in Critical Care - p. 68 63. Cause and timing of death in massively transfused trauma patients - p. 69 64. Improving Mortality Following Emergent Surgery in Older Patients Requires Focus on Complication Rescue - p. 70 65. Critical Care Medicine in the United States: Addressing the Intensivist Shortage and Image of the Specialty - p. 71 66. Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock: The CRISTAL Randomized Trial - p. 72 67. 5. Wound Healing - p. 73 68. Wound Complications in 1145 Consecutive Transumbilical Single-Incision Laparoscopic Procedures - p. 74 69. A Prospective Randomized Evaluation of Cyanoacrylate Glue Devices in the Closure of Surgical Wounds - p. 75 70. Impact of Preoperative Local Water-Filtered Infrared A Irradiation on Postoperative Wound Healing: A Randomized Patient-and Observer-Blinded Controlled Clinical Trial - p. 76 71. Systemic Review and Meta-analysis of Randomized Clinical Trials Comparing Primary vs Delayed Primary Skin Closure in Contaminated and Dirty Abdominal Incisions - p. 77 72. Preoperative Smoking Status and Postoperative Complications: A Systematic Review and Meta-analysis - p. 78 73. Negative pressure wound therapy in infants and children: a single-institution experience - p. 79 74. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life - p. 80 75. Frequency of Debridements and Time to Heal: A Retrospective Cohort Study of 312 744 Wounds - p. 81 76. Laparoscopic component separation reduces postoperative wound complications but does not alter recurrence rates in complex hernia repairs - p. 82 77. Human Acellular Dermis Seeded with Autologous Fibroblasts Enhances Bronchial Anastomotic Healing in an Irradiated Rodent Sleeve Resection Model - p. 83 78. Development of a wound healing index for patients with chronic wounds - p. 84 79. 6. Transplantation - p. 85 80. The Impact of Meeting Donor Management Goals on the Development of Delayed Graft Function in Kidney Transplant Recipients - p. 86 81. Comparing Molecular Assessment of Implantation Biopsies With Histologic and Demographic Risk Assessment - p. 87 82. Renal Transplantation After Ex Vivo Normothermic Perfusion: The First Clinical Study - p. 88 83. Strategies for Successful Left-Lobe Living Donor Liver Transplantation in 250 Consecutive Adult Cases in a Single Center - p. 89 84. Demographic, Metabolic, and Blood Pressure Characteristics of Living Kidney Donors Spanning Five Decades - p. 90 85. Preventive Intervention for Living Donor Psychosocial Outcomes: Feasibility and Efficacy in a Randomized Controlled Trial - p. 91 86. Rate of Renal Graft Function Decline After One Year Is a Strong Predictor of All-Cause Mortality - p. 92 87. Kidney Transplants With Progressing Chronic Diseases Express High Levels of Acute Kidney Injury Transcripts - p. 93 88. Five-Year Outcomes in Living Donor Kidney Transplants With a Positive Crossmatch - p. 94 89. Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival - p. 95 90. Higher Risk of Kidney Graft Failure in the Presence of Anti-Angiotensin II Type-1 Receptor Antibodies - p. 96 91. Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts - p. 97 92. Predicting End-Stage Renal Disease After Liver Transplant - p. 98 93. Class II Alloantibody and Mortality in Simultaneous Liver–Kidney Transplantation - p. 99 94. Monocytic Myeloid-Derived Suppressor Cells Accumulate in Renal Transplant Patients and Mediate CD4+ Foxp3+ Treg Expansion - p. 100 95. MicroRNA Signature at the Time of Clinical HCV Recurrence Associates With Aggressive Fibrosis Progression Post-Liver Transplantation - p. 101 96. Subclinical Epstein–Barr Virus Viremia Among Adult Renal Transplant Recipients: Incidence and Consequences - p. 102 97. Raccoon Rabies Virus Variant Transmission Through Solid Organ Transplantation - p. 103 98. Islet Survival and Function Following Intramuscular Autotransplantation in the Minipig - p. 104 99. Cyclosporine A Drives a Th17- and Th2-Mediated Posttransplant Obliterative Airway Disease - p. 105 100. 7. Surgical Infections - p. 106 101. Financial Impact of Surgical Site Infections on Hospitals: The Hospital Management Perspective - p. 107 102. Risk Factors for Superficial vs Deep/Organ-Space Surgical Site Infections: Implications for Quality Improvement Initiatives - p. 108 103. Oral Antibiotic Bowel Preparation Reduces Length of Stay and Readmissions after Colorectal Surgery - p. 109 104. Timing of Surgical Antibiotic Prophylaxis and the Risk of Surgical Site Infection - p. 110 105. Is It Time to Refine? An Exploration and Simulation of Optimal Antibiotic Timing in General Surgery - p. 111 106. Wound Classification in Pediatric General Surgery: Significant Variation Exists among Providers - p. 112 107. What Is the Quality of Reporting of Studies of Interventions to Increase Compliance with Antibiotic Prophylaxis? - p. 113 108. Tailoring the Operative Approach for Appendicitis to the Patient: A Prediction Model from National Surgical Quality Improvement Program Data - p. 114 109. Antibiotics vs Appendectomy for Uncomplicated Acute Appendicitis - p. 115 110. Postoperative Antibacterial Prophylaxis for the Prevention of Infectious Complications Associated With Tube Thoracostomy in Patients Undergoing Elective General Thoracic Surgery: A Double-blind, Placebo-Controlled, Randomized Trial - p. 116 111. Blood Transfusion for Lower Extremity Bypass Is Associated with Increased Wound Infection and Graft Thrombosis - p. 117 112. Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection - p. 118 113. Systemic Review and Meta-analysis of Randomized Clinical Trials Comparing Primary vs Delayed Primary Skin Closure in Contaminated and Dirty Abdominal Incisions - p. 119 114. Outcomes of Synthetic Mesh in Contaminated Ventral Hernia Repairs - p. 120 115. Outcomes and Predictors of Incisional Surgical Site Infection in Stoma Reversal - p. 121 116. Independent Predictors of Enteric Fistula and Abdominal Sepsis After Damage Control Laparotomy: Results From the Prospective AAST Open Abdomen Registry - p. 122 117. Development and Validation of a Necrotizing Soft-Tissue Infection Mortality Risk Calculator Using NSQIP - p. 123 118. Tedizolid Phosphate vs Linezolid for Treatment of Acute Bacterial Skin and Skin Structure Infections: The ESTABLISH-1 Randomized Trial - p. 124 119. Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis: The ACCESS Randomized Trial - p. 125 120. Effect of an Investigational Vaccine for Preventing Staphylococcus aureus Infections After Cardiothoracic Surgery: A Randomized Trial - p. 126 121. Association Between Telomere Length and Experimentally Induced Upper Respiratory Viral Infection in Healthy Adults - p. 127 122. 8. Endocrine - p. 128 123. Can Established CT Attenuation and Washout Criteria for Adrenal Adenoma Accurately Exclude Pheochromocytoma? - p. 129 124. Long-Term Cardio- and Cerebrovascular Events in Patients With Primary Aldosteronism - p. 130 125. Comparative Outcomes of Laparoscopic and Open Adrenalectomy for Adrenocortical Carcinoma: Single, High-Volume Center Experience - p. 131 126. Molecular Screening for a Personalized Treatment Approach in Advanced Adrenocortical Cancer - p. 132 127. A Comprehensive Next Generation Sequencing–Based Genetic Testing Strategy To Improve Diagnosis of Inherited Pheochromocytoma and Paraganglioma - p. 133 128. Adrenalectomy for solid tumor metastases: Results of a multicenter European study - p. 134 129. Outcome of Bilateral Adrenalectomy in Cushing's Syndrome: A Systematic Review - p. 135 130. The Role of Proinsulin and Insulin in the Diagnosis of Insulinoma: A Critical Evaluation of the Endocrine Society Clinical Practice Guideline - p. 136 131. Circulating Tumor Cells As Prognostic Markers in Neuroendocrine Tumors - p. 137 132. Presentation, Management, and Outcomes of Hyperparathyroidism in Octogenarians and Nonagenarians - p. 138 133. Bone Mineral Density Evolution After Successful Parathyroidectomy in Patients With Normocalcemic Primary Hyperparathyroidism - p. 139 134. Cardiovascular dysfunction in symptomatic primary hyperparathyroidism and its reversal after curative parathyroidectomy: Results of a prospective case control study - p. 140 135. The Clinical Course of Treated Hyperparathyroidism Among Patients Receiving Hemodialysis and the Effect of Cinacalcet: The EVOLVE Trial - p. 141 136. Preoperative BRAF(V600E) Mutation Screening Is Unlikely to Alter Initial Surgical Treatment of Patients With Indeterminate Thyroid Nodules: A Prospective Case Series of 960 Patients - p. 142 137. Targeted Next-Generation Sequencing Panel (ThyroSeq) for Detection of Mutations in Thyroid Cancer - p. 143 138. Is Potassium Iodide Solution Necessary Before Total Thyroidectomy for Graves Disease? - p. 144 139. Anaesthesia for massive retrosternal thyroidectomy in a tertiary referral centre - p. 145 140. A multi-institutional international study of risk factors for hematoma after thyroidectomy - p. 146 141. Ten percent tall cells confer the aggressive features of the tall cell variant of papillary thyroid carcinoma - p. 147 142. Stimulated Thyroglobulin at Recombinant Human TSH-Aided Ablation Predicts Disease-free Status One Year Later - p. 148 143. Does BRAF V600E Mutation Predict Aggressive Features in Papillary Thyroid Cancer? Results From Four Endocrine Surgery Centers - p. 149 144. Is Thyroid Cancer Recurrence Risk Increased After Transplantation? - p. 150 145. Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer - p. 151 146. The Clinical and Economic Burden of a Sustained Increase in Thyroid Cancer Incidence - p. 152 147. 9. Nutrition - p. 153 148. Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study - p. 154 149. Plasma Arginine Levels and Blood Glucose Control in Very Preterm Infants Receiving 2 Different Parenteral Nutrition Regimens - p. 155 150. Clinical Effects of Probiotic Bifidobacterium longum BB536 on Immune Function and Intestinal Microbiota in Elderly Patients Receiving Enteral Tube Feeding - p. 156 151. A Protocol of Early Aggressive Acceleration of Tube Feeding Increases Ileus Without Perceptible Benefit in Severely Burned Patients - p. 157 152. A Disease-Specific Enteral Nutrition Formula Improves Nutritional Status and Functional Performance in Patients With Head and Neck and Esophageal Cancer Undergoing Chemoradiotherapy: Results of a Randomized, Controlled, Multicenter Trial - p. 158 153. Parenteral Fish Oil Lipid Emulsions in the Critically Ill: A Systematic Review and Meta-Analysis - p. 159 154. Use of Exclusive Enteral Nutrition Is Just as Effective as Corticosteroids in Newly Diagnosed Pediatric Crohn's Disease - p. 160 155. Tolerability and Safety of Enteral Nutrition in Critically Ill Patients Receiving Intravenous Vasopressor Therapy - p. 161 156. Impact of Early Parenteral Nutrition on Muscle and Adipose Tissue Compartments During Critical Illness - p. 162 157. Effect of Hyperalimentation and Insulin-Treated Hyperglycemia on Tyrosine Levels in Very Preterm Infants Receiving Parenteral Nutrition - p. 163 158. Arginine appearance and nitric oxide synthesis in critically ill infants can be increased with a protein-energy–enriched enteral formula - p. 164 159. Early Enteral Nutrition Prevents Intra-abdominal Hypertension and Reduces the Severity of Severe Acute Pancreatitis Compared with Delayed Enteral Nutrition: A Prospective Pilot Study - p. 165 160. Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol in Critically Ill Patients: Results of a Cluster Randomized Trial - p. 166 161. Clinical and Immunological Impact of Early Postoperative Enteral Immunonutrition After Total Gastrectomy in Gastric Cancer Patients: A Prospective Randomized Study - p. 167 162. Enteral L-Arginine Supplementation for Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Neonates: A Double-Blind Randomized Pilot Study of Efficacy and Safety - p. 168 163. Early Enteral Fat Supplement and Fish Oil Increases Fat Absorption in the Premature Infant with an Enterostomy - p. 169 164. Minimizing unnecessary parenteral nutrition after appendectomy in children - p. 170 165. Multiple Micronutrient Deficiencies among Patients with Intestinal Failure during and after Transition to Enteral Nutrition - p. 171 166. Body composition in paediatric intestinal failure patients receiving long-term parenteral nutrition - p. 172 167. Protocol-Driven Enteral Nutrition in Critically Ill Children: A Systematic Review - p. 173 168. Lack of Preoperative Enteral Nutrition Reduces Gut-Associated Lymphoid Cell Numbers in Colon Cancer Patients: A Possible Mechanism Underlying Increased Postoperative Infectious Complications During Parenteral Nutrition - p. 174 169. Serial Transverse Enteroplasty Allows Children with Short Bowel to Wean from Parenteral Nutrition - p. 175 170. Effect of intravenous lipid emulsion in patients with acute glyphosate intoxication - p. 176 171. Physical and Cognitive Performance of Patients with Acute Lung Injury 1 Year after Initial Trophic versus Full Enteral Feeding: EDEN Trial Follow-up - p. 177 172. Variation in Feeding Practices following the Norwood Procedure - p. 178 173. The Association Between Home Parenteral Nutrition and Patients With FAP-Associated Intra-Abdominal Desmoids: A Retrospective Study - p. 179 174. Alternative lipid emulsions in the critically ill: a systematic review of the evidence - p. 180 175. Postoperative Enteral Nutrition Improves Survival After Orthotopic Small Bowel Transplantation in Mice - p. 181 176. Circadian Rhythm of Energy Expenditure and Oxygen Consumption - p. 182 177. Tube Feeding Increases the Gastric-Emptying Rate Determined by Gastroesophageal Scintigraphy - p. 183 178. 10. Gastrointestinal - p. 184 179. Patient perspectives on postoperative visits after common general operative procedures - p. 185 180. A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery - p. 186 181. Current Treatment and Outcome of Esophageal Perforations in Adults: Systematic Review and Meta-Analysis of 75 Studies - p. 187 182. Hospital volume, proportion resected and mortality from oesophageal and gastric cancer: a population-based study in England, 2004–2008 - p. 188 183. A Decade Analysis of Trends and Outcomes of Partial Versus Total Esophagectomy in the United States - p. 189 184. Outcomes After Laparoscopic or Open Distal Gastrectomy for Early-Stage Gastric Cancer: A Propensity-Matched Analysis - p. 190 185. Peroral Endoscopic Myotomy Is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Redo Surgical Heller Myotomy: A Single Center Prospective Study - p. 191 186. Gastric Emptying as a Prognostic Factor for Long-term Results of Total Laparoscopic Fundoplication for Weakly Acidic or Mixed Reflux - p. 192 187. The Comparative Effectiveness of Sleeve Gastrectomy, Gastric Bypass, and Adjustable Gastric Banding Procedures for the Treatment of Morbid Obesity - p. 193 188. Hand-Sewn Versus Mechanical Esophagogastric Anastomosis After Esophagectomy: A Systematic Review and Meta-Analysis - p. 194 189. The use of laparoscopic ultrasound in difficult cholecystectomy cases significantly decreases morbidity - p. 195 190. Predictors of Incidental Gallbladder Cancer in Patients Undergoing Cholecystectomy for Benign Gallbladder Disease - p. 196 191. Changing Trends and Outcomes in the Use of Percutaneous Cholecystostomy Tubes for Acute Cholecystitis - p. 197 192. Improved Outcomes of Bile Duct Injuries in the 21st Century - p. 198 193. Comparison of laparoscopic common bile duct exploration and endoscopic retrograde cholangiopancreatography plus laparoscopic cholecystectomy for choledocholithiasis: a prospective randomized study - p. 199 194. Laparoscopic cholecystectomy for biliary dyskinesia: Which patients have long term benefit? - p. 200 195. Partial Anterior vs Partial Posterior Fundoplication Following Transabdominal Esophagocardiomyotomy for Achalasia of the Esophagus: Meta-regression of Objective Postoperative Gastroesophageal Reflux and Dysphagia - p. 201 196. Laparoscopic Resection of Gastric and Small Bowel Gastrointestinal Stromal Tumors: 10-Year Experience at a Single Center - p. 202 197. Definitive Surgical Treatment Of Enterocutaneous Fistula: Outcomes of a 23-Year Experience - p. 203 198. A Prospective, Randomized, Noninferiority Trial of Steroid Dosing After Major Colorectal Surgery - p. 204 199. Risk adjusted benchmarking of abdominoperineal excision for rectal adenocarcinoma in the context of the Belgian PROCARE improvement project - p. 205 200. Predictors of mortality after emergent surgery for acute colonic diverticulitis: Analysis of National Surgical Quality Improvement Project data - p. 206 201. Current management of acute malignant large bowel obstruction: a systematic review - p. 207 202. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial - p. 208 203. A Novel Nomogram Accurately Quantifies the Risk of Mortality in Elderly Patients Undergoing Colorectal Surgery - p. 209 204. Equal Efficacy of Endoscopic and Surgical Cystogastrostomy for Pancreatic Pseudocyst Drainage in a Randomized Trial - p. 210 205. Postoperative Outcomes After Laparoscopic Splenectomy Compared With Open Splenectomy - p. 211 206. Randomized Clinical Trial of Intestinal Ostomy Takedown Comparing Pursestring Wound Closure vs Conventional Closure to Eliminate the Risk of Wound Infection - p. 212 207. Randomized Prospective Study to Compare Laparoscopic Appendectomy Versus Umbilical Single-Incision Appendectomy - p. 213 208. Short and Long-Term Mortality After Appendectomy in Sweden 1987 to 2006. Influence of Appendectomy Diagnosis, Sex, Age, Co-morbidity, Surgical Method, Hospital Volume, and Time Period. A National Population-Based Cohort Study - p. 214 209. Among 1,706 cases of abdominal wall reconstruction, what factors influence the occurrence of major operative complications? - p. 215 210. Glue Versus Suture Fixation of Mesh During Open Repair of Inguinal Hernias: A Systematic Review and Meta-Analysis - p. 216 211. A systematic review and meta-analysis evaluating the effectiveness of lightweight mesh against heavyweight mesh in influencing the incidence of chronic groin pain following laparoscopic inguinal hernia repair - p. 217 212. Laparoscopic component separation reduces postoperative wound complications but does not alter recurrence rates in complex hernia repairs - p. 218 213. A meta-analysis examining the use of tacker mesh fixation versus glue mesh fixation in laparoscopic inguinal hernia repair - p. 219 214. 11. Oncology - p. 220 215. 11.1. Breast - p. 221 216. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial - p. 222 217. The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials - p. 223 218. Effect of MRI on the Management of Ductal Carcinoma In Situ of the Breast - p. 224 219. Preoperative Axillary Ultrasound in Breast Cancer: Safely Avoiding Frozen Section of Sentinel Lymph Nodes in Breast Conserving Surgery - p. 225 220. When is a Lymph Node Dissection a Lymph Node Dissection? The Number of Lymph Nodes Resected in Sentinel and Axillary Lymph Node Dissections - p. 226 221. An Extended Phase II Trial of Iodine-125 Methylene Blue for Sentinel Lymph Node Identification in Women with Breast Cancer - p. 227 222. Randomized Controlled Trial to Reduce Bacterial Colonization of Surgical Drains After Breast and Axillary Operations - p. 228 223. 11.2. Colon - p. 229 224. Current Use and Surgical Efficacy of Laparoscopic Colectomy in Colon Cancer - p. 230 225. Nodal Status, Number of Lymph Nodes Examined, and Lymph Node Ratio: What Defines Prognosis after Resection of Colon Adenocarcinoma? - p. 231 226. Bevacizumab in Stage II-III Colon Cancer: 5-Year Update of the National Surgical Adjuvant Breast and Bowel Project C-08 Trial - p. 232 227. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial - p. 233 228. Epithelial Barriers, Microbiota, and Colorectal Cancer - p. 234 229. Independent Validation of a Prognostic Genomic Signature (ColoPrint) for Patients With Stage II Colon Cancer - p. 235 230. Risk Factors for Survival after Lung Metastasectomy in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis - p. 236 231. 11.3. Gastric - p. 237 232. Treatment Trends and Predictors of Adjuvant and Neoadjuvant Therapy for Gastric Adenocarcinoma in the United States - p. 238 233. Conditional Probability of Survival Nomogram for 1-, 2-, and 3-Year Survivors After an R0 Resection for Gastric Cancer - p. 239 234. 11.4. Hepatic Colorectal - p. 240 235. Surgical Management of Patients with Synchronous Colorectal Liver Metastasis: A Multicenter International Analysis - p. 241 236. Use of Bioresorbable Membranes to Reduce Abdominal and Perihepatic Adhesions in 2-Stage Hepatectomy of Liver Metastases From Colorectal Cancer: Results of a Prospective, Randomized Controlled Phase II Trial - p. 242 237. Fast-track surgery improves postoperative recovery in patients undergoing partial hepatectomy for primary liver cancer: A prospective randomized controlled trial - p. 243 238. Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy? - p. 244 239. 11.5. Rectal - p. 245 240. Impact of Robotic Surgery on Sexual and Urinary Functions After Fully Robotic Nerve-Sparing Total Mesorectal Excision for Rectal Cancer - p. 246 241. 11.6. Hepatocellular - p. 247 242. Revisiting Liver Anatomy and Terminology of Hepatectomies - p. 248 243. Radiofrequency Ablation With or Without Transcatheter Arterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Prospective Randomized Trial - p. 249 244. 11.7. Pancreatic - p. 250 245. Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection? - p. 251 246. Re-resection for Isolated Local Recurrence of Pancreatic Cancer is Feasible, Safe, and Associated with Encouraging Survival - p. 252 247. Adjuvant Chemotherapy With Gemcitabine and Long-term Outcomes Among Patients With Resected Pancreatic Cancer: The CONKO-001 Randomized Trial - p. 253 248. A prospective, randomized trial of Roux-en-Y reconstruction with isolated pancreatic drainage versus conventional loop reconstruction after pancreaticoduodenectomy - p. 254 249. Pylorus resection in partial pancreaticoduodenectomy: impact on delayed gastric emptying - p. 255 250. Population-Level Analysis of Pancreatic Neuroendocrine Tumors 2 cm or Less in Size - p. 256 251. 11.8. Neuroendocrine - p. 257 252. Resection of At-Risk Mesenteric Lymph Nodes Is Associated with Improved Survival in Patients with Small Bowel Neuroendocrine Tumors - p. 258 253. Prognostic Validity of the American Joint Committee on Cancer Staging Classification for Midgut Neuroendocrine Tumors - p. 259 254. 11.9. Melanoma - p. 260 255. Evidence for a Better Nodal Staging System for Melanoma: The Clinical Relevance of Metastatic Disease Confined to the Sentinel Lymph Nodes - p. 261 256. Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women - p. 262 257. 11.10. Other - p. 263 258. Quantification of harms in cancer screening trials: literature review - p. 264 259. Management of Patients with Abdominal Malignancy after Remote Jejunoileal Bypass: Surgical Considerations Decades Later - p. 265 260. 12. Vascular Surgery - p. 267 261. 12.1. Aneurysm - p. 268 262. Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm - p. 269 263. Endovascular Repair Versus Open Repair of Ruptured Abdominal Aortic Aneurysms: A Multicenter Randomized Controlled Trial - p. 270 264. Comparison of fenestrated endovascular and open repair of abdominal aortic aneurysms not suitable for standard endovascular repair - p. 271 265. Endovascular Repair of Type B Aortic Dissection: Long-term Results of the Randomized Investigation of Stent Grafts in Aortic Dissection Trial - p. 272 266. Surveillance Intervals for Small Abdominal Aortic Aneurysms: A Meta-analysis - p. 273 267. The current management of isolated degenerative femoral artery aneurysms is too aggressive for their natural history - p. 274 268. Compliance with long-term surveillance recommendations following endovascular aneurysm repair or type B aortic dissection - p. 275 269. Pathogenesis and Management of Retrograde Type A Aortic Dissection After Thoracic Endovascular Aortic Repair - p. 276 270. Delayed volume resuscitation during initial management of ruptured abdominal aortic aneurysm - p. 277 271. Statin therapy is associated with improved survival after endovascular and open aneurysm repair - p. 278 272. 12.2. Peripheral Arterial Occlusive Disease - p. 279 273. Stent Placement Versus Balloon Angioplasty for the Treatment of Obstructive Lesions of the Popliteal Artery: A Prospective, Multicenter, Randomized Trial - p. 280 274. Predictors and outcomes of restenosis following tibial artery endovascular interventions for critical limb ischemia - p. 281 275. Clinical consequence of bare metal stent and stent graft failure in femoropopliteal occlusive disease - p. 282 276. The Risk of Major Elective Vascular Surgical Procedures in Patients With End-Stage Renal Disease - p. 283 277. Vacuum-assisted wound closure versus alginate for the treatment of deep perivascular wound infections in the groin after vascular surgery - p. 284 278. Platelet Responsiveness to Clopidogrel Treatment After Peripheral Endovascular Procedures: The PRECLOP Study: Clinical Impact and Optimal Cutoff Value of On-Treatment High Platelet Reactivity - p. 285 279. 12.3. Venous - p. 286 280. Outcomes of endovascular intervention for May-Thurner syndrome - p. 287 281. Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins - p. 288 282. Managing iliofemoral deep venous thrombosis of pregnancy with a strategy of thrombus removal is safe and avoids post-thrombotic morbidity - p. 289 283. Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis - p. 290 284. 12.4. Carotid - p. 291 285. Management of carotid stenosis in women: consensus document - p. 292 286. The risk of carotid artery stenting compared with carotid endarterectomy is greatest in patients treated within 7 days of symptoms - p. 293 287. 12.5. Access - p. 294 288. Fistula First Is Not Always the Best Strategy for the Elderly - p. 295 289. 12.6. Miscellaneous - p. 296 290. Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis - p. 297 291. Discontinuation of preoperative clopidogrel is unnecessary in peripheral arterial surgery - p. 298 292. 13. General Thoracic Surgery - p. 299 293. 13.1. Intra-Operative Concerns - p. 300 294. Subxiphoid pericardial window to exclude occult cardiac injury after penetrating thoracoabdominal trauma - p. 301 295. Midodrine: A Novel Therapeutic for Refractory Chylothorax - p. 302 296. State of the Art of Robotic Thymectomy - p. 303 297. Complications of Bronchial Stapling in Thoracic Surgery - p. 304 298. 13.2. Pre- and Postoperative Management - p. 305 299. Outcomes of endovascular repair for blunt thoracic aortic injury - p. 306 300. Chylothorax Complicating Pulmonary Resection for Lung Cancer: Effective Management and Pleurodesis - p. 307 301. Low-fat diet management strategy for chylothorax after pulmonary resection and lymph node dissection for primary lung cancer - p. 308 302. Does External Pleural Suction Reduce Prolonged Air Leak After Lung Resection? Results From the AirINTrial After 500 Randomized Cases - p. 309 303. Optimal Timing of Thoracoscopic Drainage and Decortication for Empyema - p. 310 304. 13.3. Miscellaneous - p. 311 305. Randomized clinical trial of pigtail catheter versus chest tube in injured patients with uncomplicated traumatic pneumothorax - p. 312 306. Traumatic tricuspid valve rupture presenting as third-degree atrioventricular block - p. 313 307. Outcomes of Cholecystectomy in US Heart Transplant Recipients - p. 314 308. Operative Management of Rib Fractures in the Setting of Flail Chest: A Systematic Review and Meta-Analysis - p. 315 309. Hemorrhagic Complications of Thoracentesis and Small-Bore Chest Tube Placement in Patients Taking Clopidogrel - p. 316 310. Commercial Air Travel After Pneumothorax: A Review of the Literature - p. 317 311. Slipping Rib Syndrome in an Adolescent: An Elusive Diagnosis - p. 318 312. Arterial Thoracic Outlet Syndrome: A 32-Year Experience - p. 319 313. 13.4. Benign Esophageal Disease - p. 320 314. Esophagography After Pneumomediastinum Without CT Findings of Esophageal Perforation: Is It Necessary? - p. 321 315. 13.5. Tumor Biology and Prognostic Variables - p. 322 316. Does the Mode of Surgical Resection Affect the Prognosis/Recurrence in Patients With Thymoma? - p. 323 317. 13.6. Staging of Non-small Lung Cancer - p. 324 318. A National Study of Nodal Upstaging After Thoracoscopic Versus Open Lobectomy for Clinical Stage I Lung Cancer - p. 325