A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xvii 6. Preface - p. xxi 7. Part I. Principles & Concepts - p. xxiii 8. Chapter 1. What Can We Learn From This Book? - p. 3 9. Chapter 2. Features of Mesenchymal Stem Cells - p. 15 10. Chapter 3. Maintenance and Culture of MSCs - p. 39 11. Chapter 4. Manufacturing Mesenchymal Stromal Cell Banks - p. 63 12. Part II. Promises and Challenges of MSC-Based Therapies - p. 84 13. Chapter 5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic Strategies - p. 87 14. Chapter 6. Mesenchymal Stem Cell Therapy in Graft Versus Host Disease - p. 111 15. Chapter 7. Systemic Lupus Erythematosus - p. 143 16. Chapter 8. Mesenchymal Stem Cell–Based Therapies for Repair and Regeneration of Skin Wounds - p. 173 17. Chapter 9. Myocardial Infarction - p. 223 18. Chapter 10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus - p. 251 19. Chapter 11. Mesenchymal Stem Cell–Based Therapy for Chronic Kidney Disease - p. 275 20. Chapter 12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and Parkinsonism - p. 297 21. Chapter 13. Spinal Cord Injury - p. 321 22. Chapter 14. Stem Cell–Based Restoration of Salivary Gland Function - p. 345 23. Chapter 15. Tooth and Dental Pulp Regeneration - p. 367 24. Part III. Future Perspectives - p. 392 25. Chapter 16. MSCs as Biological Drugs - p. 395 26. Chapter 17. Mesenchymal Stem Cell–Derived Products for Tissue Repair and Regeneration - p. 419 27. Chapter 18. Use of MSCs in Antiaging Strategies - p. 443 28. Chapter 19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India, Argentina, and Brazil - p. 463 29. Index - p. 493
A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xvii 6. Preface - p. xxi 7. Part I. Principles & Concepts - p. xxiii 8. Chapter 1. What Can We Learn From This Book? - p. 3 9. Chapter 2. Features of Mesenchymal Stem Cells - p. 15 10. Chapter 3. Maintenance and Culture of MSCs - p. 39 11. Chapter 4. Manufacturing Mesenchymal Stromal Cell Banks - p. 63 12. Part II. Promises and Challenges of MSC-Based Therapies - p. 84 13. Chapter 5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic Strategies - p. 87 14. Chapter 6. Mesenchymal Stem Cell Therapy in Graft Versus Host Disease - p. 111 15. Chapter 7. Systemic Lupus Erythematosus - p. 143 16. Chapter 8. Mesenchymal Stem Cell–Based Therapies for Repair and Regeneration of Skin Wounds - p. 173 17. Chapter 9. Myocardial Infarction - p. 223 18. Chapter 10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus - p. 251 19. Chapter 11. Mesenchymal Stem Cell–Based Therapy for Chronic Kidney Disease - p. 275 20. Chapter 12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and Parkinsonism - p. 297 21. Chapter 13. Spinal Cord Injury - p. 321 22. Chapter 14. Stem Cell–Based Restoration of Salivary Gland Function - p. 345 23. Chapter 15. Tooth and Dental Pulp Regeneration - p. 367 24. Part III. Future Perspectives - p. 392 25. Chapter 16. MSCs as Biological Drugs - p. 395 26. Chapter 17. Mesenchymal Stem Cell–Derived Products for Tissue Repair and Regeneration - p. 419 27. Chapter 18. Use of MSCs in Antiaging Strategies - p. 443 28. Chapter 19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India, Argentina, and Brazil - p. 463 29. Index - p. 493
