Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction.
Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease.
This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age.
This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances.
1. Introduction - p. 217 2. Prevalence of PSU - p. 218 3. Overview of Cognition in Monosubstance Users - p. 219 4. Overview of Neuroimaging in Monosubstance Users - p. 220 5. Review of Cognition in Polysubstance Users - p. 221 6. Review of Neuroimaging in Polysubstance Users - p. 225 7. Review Summary and Outlook - p. 230 8. Chapter 22. Deep Brain Stimulation: A Possible Therapeutic Technique for Treating Refractory Alcohol and Drug Addiction Behaviors - p. 239 9. Part III. Tobacco Smoking in Neuromodulation - p. 248 10. Chapter 23. Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use - p. 251 11. Introduction - p. 251 12. The Brain Disease Model of Nicotine Dependence - p. 252 13. Elucidating the Neurobiology of Nicotine Dependence Using Structural Magnetic Resonance Imaging - p. 252 14. The Genetic Epidemiology of Smoking and Brain Structure - p. 256 15. Twin and Family Studies - p. 256 16. Understanding the Neurobiological Pathways Involved in Nicotine Dependence - p. 259 17. Gene-Based Genetic Epidemiological Study Designs - p. 260 18. Candidate Gene Association Studies - p. 260 19. Genome-Wide Association Studies - p. 261 20. The Impact of Genome-Wide Significant Variants for Smoking on Brain Structure - p. 262 21. Limitations of Genetic Association Studies - p. 262 22. Epigenetic Studies - p. 263 23. DNA Methylation and Smoking Behavior - p. 263 24. Epigenetic Studies of Brain Morphology - p. 264 25. Future Directions - p. 264 26. Chapter 24. Tobacco Smoke and Nicotine: Neurotoxicity in Brain Development - p. 273 27. Chapter 25. Paradise Lost: A New Paradigm for Explaining the Interaction Between Neural and Psychological Changes in Nicotine Addiction Patients - p. 281 28. Chapter 26. Interactions of Alcohol and Nicotine: CNS Sites and Contributions to Their Co-abuse - p. 293 29. Chapter 27. Role of Basal Forebrain in Nicotine Alcohol Co-abuse - p. 307 30. Chapter 28. Chronic and Acute Nicotine Exposure Versus Placebo in Smokers and Nonsmokers: A Systematic Review of Resting-State fMRI Studies - p. 319 31. Part IV. Drugs of Abuse and Brain Structure and Function - p. 338 32. Chapter 29. Novel Psychoactive Substances: A New Behavioral and Mental Health Threat - p. 341 33. Chapter 30. Cholesterol and Caffeine Modulate Alcohol Actions on Cerebral Arteries and Brain - p. 355 34. Chapter 31. Sleep, Caffeine, and Physical Activity in Older Adults - p. 365 35. Chapter 32. Ketamine: Neurotoxicity and Neurobehavioral Disorders - p. 373 36. Chapter 33. Left/Right Hemispheric “Unbalance” Model in Addiction - p. 383 37. Index - p. 393
Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction.
Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease.
This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age.
This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances.
1. Introduction - p. 217 2. Prevalence of PSU - p. 218 3. Overview of Cognition in Monosubstance Users - p. 219 4. Overview of Neuroimaging in Monosubstance Users - p. 220 5. Review of Cognition in Polysubstance Users - p. 221 6. Review of Neuroimaging in Polysubstance Users - p. 225 7. Review Summary and Outlook - p. 230 8. Chapter 22. Deep Brain Stimulation: A Possible Therapeutic Technique for Treating Refractory Alcohol and Drug Addiction Behaviors - p. 239 9. Part III. Tobacco Smoking in Neuromodulation - p. 248 10. Chapter 23. Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use - p. 251 11. Introduction - p. 251 12. The Brain Disease Model of Nicotine Dependence - p. 252 13. Elucidating the Neurobiology of Nicotine Dependence Using Structural Magnetic Resonance Imaging - p. 252 14. The Genetic Epidemiology of Smoking and Brain Structure - p. 256 15. Twin and Family Studies - p. 256 16. Understanding the Neurobiological Pathways Involved in Nicotine Dependence - p. 259 17. Gene-Based Genetic Epidemiological Study Designs - p. 260 18. Candidate Gene Association Studies - p. 260 19. Genome-Wide Association Studies - p. 261 20. The Impact of Genome-Wide Significant Variants for Smoking on Brain Structure - p. 262 21. Limitations of Genetic Association Studies - p. 262 22. Epigenetic Studies - p. 263 23. DNA Methylation and Smoking Behavior - p. 263 24. Epigenetic Studies of Brain Morphology - p. 264 25. Future Directions - p. 264 26. Chapter 24. Tobacco Smoke and Nicotine: Neurotoxicity in Brain Development - p. 273 27. Chapter 25. Paradise Lost: A New Paradigm for Explaining the Interaction Between Neural and Psychological Changes in Nicotine Addiction Patients - p. 281 28. Chapter 26. Interactions of Alcohol and Nicotine: CNS Sites and Contributions to Their Co-abuse - p. 293 29. Chapter 27. Role of Basal Forebrain in Nicotine Alcohol Co-abuse - p. 307 30. Chapter 28. Chronic and Acute Nicotine Exposure Versus Placebo in Smokers and Nonsmokers: A Systematic Review of Resting-State fMRI Studies - p. 319 31. Part IV. Drugs of Abuse and Brain Structure and Function - p. 338 32. Chapter 29. Novel Psychoactive Substances: A New Behavioral and Mental Health Threat - p. 341 33. Chapter 30. Cholesterol and Caffeine Modulate Alcohol Actions on Cerebral Arteries and Brain - p. 355 34. Chapter 31. Sleep, Caffeine, and Physical Activity in Older Adults - p. 365 35. Chapter 32. Ketamine: Neurotoxicity and Neurobehavioral Disorders - p. 373 36. Chapter 33. Left/Right Hemispheric “Unbalance” Model in Addiction - p. 383 37. Index - p. 393
