Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.
1. Chapter one : Introduction: Organic Chemistry in the Nineteenth Century - p. Page vi 2. Chapter TWO : Vladimir Vasil'evich Markovnikov and his rule for addition - p. Page 10 3. Chapter Three : Markovnikov's rule: history and development - p. Page 46 4. Chapter Four : Aleksandr Mikhailovich Zaitsev and his empirical rule for elimination - p. Page 67 5. Chapter Five : August Wilhelm von Hofmann and Hofmann's rule for elimination - p. Page 101 6. Chapter Six : Paul Walden and the Walden inversion - p. Page 133 7. Chapter Seven : Mechanistic studies - p. Page 156 8. Chapter Eight : Development of highly regioselective addition reactions of alkenes and alkynes - p. Page 185 9. Chapter Nine : Development of highly regiospecific alkene syntheses: elimination and its substitutes - p. Page 222 10. Chapter Ten : Inversion of configuration in modern synthesis - p. Page 241 11. Index - p. Page 262
Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.
1. Chapter one : Introduction: Organic Chemistry in the Nineteenth Century - p. Page vi 2. Chapter TWO : Vladimir Vasil'evich Markovnikov and his rule for addition - p. Page 10 3. Chapter Three : Markovnikov's rule: history and development - p. Page 46 4. Chapter Four : Aleksandr Mikhailovich Zaitsev and his empirical rule for elimination - p. Page 67 5. Chapter Five : August Wilhelm von Hofmann and Hofmann's rule for elimination - p. Page 101 6. Chapter Six : Paul Walden and the Walden inversion - p. Page 133 7. Chapter Seven : Mechanistic studies - p. Page 156 8. Chapter Eight : Development of highly regioselective addition reactions of alkenes and alkynes - p. Page 185 9. Chapter Nine : Development of highly regiospecific alkene syntheses: elimination and its substitutes - p. Page 222 10. Chapter Ten : Inversion of configuration in modern synthesis - p. Page 241 11. Index - p. Page 262
