Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.
Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.
1. Chapter 1. Introduction to cancer - p. 5 2. Chapter 2. Current practices in cancer chemotherapy - p. 27 3. Chapter 3. Emerging trend in anticancer drug delivery - p. 51 4. Chapter 4. Cancer therapy depending on tumor stroma - p. 79 5. Chapter 5. Targeting cancer cell respiration in hypoxic and acidic tumor microenvironment: Exploring the therapeutic interventions - p. 95 6. Chapter 6. Cancer therapy depending on tumor vasculature and EPR effects - p. 121 7. Chapter 7. Cancer therapy based on extracellular matrix - p. 145 8. Chapter 8. Heterogenicity of cancer and drug resistance - p. 159 9. Chapter II. Strategies and technologies for cancer therapy - p. P2 10. Chapter II Strategies and technologies for cancer therapy - p. 177 11. Chapter 9. Materials and strategies for advanced anticancer drug delivery - p. 179 12. Chapter 10. Drug conjugates for anticancer drug delivery - p. 221 13. Chapter 11. Self-assembled supramolecular systems for anticancer drug delivery - p. 237 14. Chapter 12. Advances in metal-organic frameworks for anticancer drug delivery - p. 269 15. Chapter 13. Tumor microenvironment targeted drug delivery systems - p. 291 16. Chapter 14. Advances in dendrimers for anticancer drug delivery - p. 317 17. Chapter 15. Advances in metallic nanoparticles for anticancer drug delivery - p. 343 18. Chapter 16. Advances in polymeric nanoparticles for anticancer drug delivery - p. 359 19. Chapter 17. Advances in lipid-based nanoparticles for anticancer drug delivery - p. 395 20. Chapter 18. Advances in SNEDDS for anticancer drug delivery - p. 443 21. Chapter 19. Advances in nanocrystals for anticancer drug delivery - p. 461 22. Chapter 20. Theranostic nanoparticles for advanced cancer therapy - p. 483 23. Chapter 21. DNA based nanomaterials for anticancer therapy - p. 511 24. Chapter 22. Nanofibrous scaffolds for cancer management - p. 555 25. Chapter 23. Advances in hydrogel for anticancer drug delivery - p. 589 26. Chapter 24. Advances in inorganic nanocarriers for anticancer drug delivery - p. 611 27. Chapter 25. Microparticles for anticancer drug delivery - p. 633 28. Chapter 26. Microneedles for anticancer drug delivery - p. 649 29. Chapter 27. Implants for anticancer drug delivery - p. 681 30. Chapter 28. Phytomedicine for cancer therapy - p. 699 31. Chapter 29. Small molecules as delivery tools for enzymes employed in enzyme-prodrug therapy - p. 729 32. Chapter III. Clinical status, challenges, and future prospectives - p. P3 33. Chapter III Clinical status, challenges, and future prospectives - p. 753 34. Chapter 30. Clinical status of anticancer drug delivery systems - p. 755 35. Chapter 31. Challenges and future prospectives in anticancer drug delivery - p. 787 36. Chapter 32. Regulatory considerations for anticancer drug delivery systems - p. 801 37. Index - p. 821
Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.
Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.
1. Chapter 1. Introduction to cancer - p. 5 2. Chapter 2. Current practices in cancer chemotherapy - p. 27 3. Chapter 3. Emerging trend in anticancer drug delivery - p. 51 4. Chapter 4. Cancer therapy depending on tumor stroma - p. 79 5. Chapter 5. Targeting cancer cell respiration in hypoxic and acidic tumor microenvironment: Exploring the therapeutic interventions - p. 95 6. Chapter 6. Cancer therapy depending on tumor vasculature and EPR effects - p. 121 7. Chapter 7. Cancer therapy based on extracellular matrix - p. 145 8. Chapter 8. Heterogenicity of cancer and drug resistance - p. 159 9. Chapter II. Strategies and technologies for cancer therapy - p. P2 10. Chapter II Strategies and technologies for cancer therapy - p. 177 11. Chapter 9. Materials and strategies for advanced anticancer drug delivery - p. 179 12. Chapter 10. Drug conjugates for anticancer drug delivery - p. 221 13. Chapter 11. Self-assembled supramolecular systems for anticancer drug delivery - p. 237 14. Chapter 12. Advances in metal-organic frameworks for anticancer drug delivery - p. 269 15. Chapter 13. Tumor microenvironment targeted drug delivery systems - p. 291 16. Chapter 14. Advances in dendrimers for anticancer drug delivery - p. 317 17. Chapter 15. Advances in metallic nanoparticles for anticancer drug delivery - p. 343 18. Chapter 16. Advances in polymeric nanoparticles for anticancer drug delivery - p. 359 19. Chapter 17. Advances in lipid-based nanoparticles for anticancer drug delivery - p. 395 20. Chapter 18. Advances in SNEDDS for anticancer drug delivery - p. 443 21. Chapter 19. Advances in nanocrystals for anticancer drug delivery - p. 461 22. Chapter 20. Theranostic nanoparticles for advanced cancer therapy - p. 483 23. Chapter 21. DNA based nanomaterials for anticancer therapy - p. 511 24. Chapter 22. Nanofibrous scaffolds for cancer management - p. 555 25. Chapter 23. Advances in hydrogel for anticancer drug delivery - p. 589 26. Chapter 24. Advances in inorganic nanocarriers for anticancer drug delivery - p. 611 27. Chapter 25. Microparticles for anticancer drug delivery - p. 633 28. Chapter 26. Microneedles for anticancer drug delivery - p. 649 29. Chapter 27. Implants for anticancer drug delivery - p. 681 30. Chapter 28. Phytomedicine for cancer therapy - p. 699 31. Chapter 29. Small molecules as delivery tools for enzymes employed in enzyme-prodrug therapy - p. 729 32. Chapter III. Clinical status, challenges, and future prospectives - p. P3 33. Chapter III Clinical status, challenges, and future prospectives - p. 753 34. Chapter 30. Clinical status of anticancer drug delivery systems - p. 755 35. Chapter 31. Challenges and future prospectives in anticancer drug delivery - p. 787 36. Chapter 32. Regulatory considerations for anticancer drug delivery systems - p. 801 37. Index - p. 821
