Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and longevity. The first part examines histological, structural, physiological, and functional changes that contribute to age-related declines in kidney function. The role of nutrition and proteomics is also discussed. The second part examines the functional decline in elderly patients and includes subparts on impaired quality of life, sleep quality, fall risk, frailty, depression, and sarcopenia. It also considers unique features of hypertension, diabetes, glomerulonephritis, and peripheral vascular disease.
The final part focuses on diagnostic, management, and prevention strategies. Common myths about chronic kidney disease in the elderly are addressed, with particular attention to how a solitary kidney in living donors ages over time. In addition, kidney function and its relationship to neurologic complications, cancers, and cardiovascular disease are explained, along with current treatment approaches, medications, and future directions in the care of elderly patients.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. About the cover - p. v 7. Contributors - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Part 1: Mechanisms of aging in the kidney - p. P1 11. Chapter 1 Structural and functional changes in aging - p. 3 12. Chapter 2 Models of kidney aging - p. 11 13. Chapter 3 Molecular mechanisms of aging - p. 23 14. Chapter4 A review of podocyte senescence and aging - p. 45 15. Chapter 5 Epigenetics and the kidney - p. 71 16. Chapter 6 The influence of acute kidney injury on aging - p. 117 17. Chapter 7 Nutritional considerations and aging - p. 133 18. Chapter 8 Proteomics - p. 163 19. Part 2: Unique characteristics of kidney diseases in the elderly - p. P2 20. Chapter 9 Impaired quality of life in elderly CKD patients - p. 177 21. Chapter 10 Sleep - p. 193 22. Chapter 11 Falls - p. 207 23. Chapter 12 Fatigue and frailty in kidney disease - p. 229 24. Chapter 13 Hospitalizations - p. 245 25. Chapter 14 Depression - p. 253 26. Chapter 15 Sarcopenia - p. 275 27. Part 3: Aging in specific diseases - p. P3 28. Chapter 16 Hypertension - p. 299 29. Chapter 17 Diabetes in kidney disease progression - p. 315 30. Chapter 18 Glomerulonephritis - p. 333 31. Chapter 19 Peripheral vascular disease - p. 347 32. Part 4: Management and prevention - p. P4 33. Chapter 20 Diagnosis of CKD in an elderly individual, due to a decline in GFR with normal healthy aging - p. 367 34. Chapter 21 Myths about chronic kidney disease in the elderly - p. 387 35. Chapter 22 The living donor and aging - p. 405 36. Chapter 23 CNS limitations in elderly kidney patients - p. 429 37. Chapter 24 Cancer and the kidney in an elderly individual - p. 451 38. Chapter 25 Cardiovascular disease in aging kidney - p. 471 39. Chapter 26 Benefits of renin angiotensin aldosterone system blockage - p. 487 40. Chapter 27 Active medical care without dialysis - p. 507 41. Chapter 28 Drugs to avoid with geriatric kidney disease - p. 529 42. Chapter 29 Innovations in chronic kidney disease and aging - p. 539 43. Index - p. 559
Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and longevity. The first part examines histological, structural, physiological, and functional changes that contribute to age-related declines in kidney function. The role of nutrition and proteomics is also discussed. The second part examines the functional decline in elderly patients and includes subparts on impaired quality of life, sleep quality, fall risk, frailty, depression, and sarcopenia. It also considers unique features of hypertension, diabetes, glomerulonephritis, and peripheral vascular disease.
The final part focuses on diagnostic, management, and prevention strategies. Common myths about chronic kidney disease in the elderly are addressed, with particular attention to how a solitary kidney in living donors ages over time. In addition, kidney function and its relationship to neurologic complications, cancers, and cardiovascular disease are explained, along with current treatment approaches, medications, and future directions in the care of elderly patients.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. About the cover - p. v 7. Contributors - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Part 1: Mechanisms of aging in the kidney - p. P1 11. Chapter 1 Structural and functional changes in aging - p. 3 12. Chapter 2 Models of kidney aging - p. 11 13. Chapter 3 Molecular mechanisms of aging - p. 23 14. Chapter4 A review of podocyte senescence and aging - p. 45 15. Chapter 5 Epigenetics and the kidney - p. 71 16. Chapter 6 The influence of acute kidney injury on aging - p. 117 17. Chapter 7 Nutritional considerations and aging - p. 133 18. Chapter 8 Proteomics - p. 163 19. Part 2: Unique characteristics of kidney diseases in the elderly - p. P2 20. Chapter 9 Impaired quality of life in elderly CKD patients - p. 177 21. Chapter 10 Sleep - p. 193 22. Chapter 11 Falls - p. 207 23. Chapter 12 Fatigue and frailty in kidney disease - p. 229 24. Chapter 13 Hospitalizations - p. 245 25. Chapter 14 Depression - p. 253 26. Chapter 15 Sarcopenia - p. 275 27. Part 3: Aging in specific diseases - p. P3 28. Chapter 16 Hypertension - p. 299 29. Chapter 17 Diabetes in kidney disease progression - p. 315 30. Chapter 18 Glomerulonephritis - p. 333 31. Chapter 19 Peripheral vascular disease - p. 347 32. Part 4: Management and prevention - p. P4 33. Chapter 20 Diagnosis of CKD in an elderly individual, due to a decline in GFR with normal healthy aging - p. 367 34. Chapter 21 Myths about chronic kidney disease in the elderly - p. 387 35. Chapter 22 The living donor and aging - p. 405 36. Chapter 23 CNS limitations in elderly kidney patients - p. 429 37. Chapter 24 Cancer and the kidney in an elderly individual - p. 451 38. Chapter 25 Cardiovascular disease in aging kidney - p. 471 39. Chapter 26 Benefits of renin angiotensin aldosterone system blockage - p. 487 40. Chapter 27 Active medical care without dialysis - p. 507 41. Chapter 28 Drugs to avoid with geriatric kidney disease - p. 529 42. Chapter 29 Innovations in chronic kidney disease and aging - p. 539 43. Index - p. 559
