Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.
This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.
1. Mitochondrial Dysfunction and Nanotherapeutics - p. i 2. Cover - p. i 3. Title page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xix 8. About the editor - p. xxvii 9. Preface - p. xxix 10. Acknowledgments - p. xxxiii 11. Chapter 1 Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging - p. 1 12. Chapter 2 Mitochondrial dysfunction in inborn errors of metabolism - p. 35 13. Chapter 3 Impaired mitochondrial dynamics in disease - p. 57 14. Chapter 4 Mitochondrial dysfunction in metabolic disorders - p. 91 15. Chapter 5 Mitochondrial dysfunction and autophagy in neurodegeneration - p. 139 16. Chapter 6 Mitochondrial dysfunction in sepsis - p. 179 17. Chapter 7 Drug- or toxin-induced mitochondrial toxicity - p. 203 18. Chapter 8 Aging, mitochondria, and autophagy - p. 221 19. Chapter 9 Skin aging and mitochondria - p. 237 20. Chapter 10 Organelle targeting: Focus on the mitochondria - p. 261 21. Chapter 11 Nanotechnology, mitochondria, and cancer - p. 291 22. Chapter 12 Nanomaterials aimed toward the cardiac mitochondria: from therapeutics to nanosafety - p. 311 23. Chapter 13 Increasing resveratrol bioavailability: A therapeutic challenge focusing on the mitochondria - p. 349 24. Chapter 14 Advances in nanotechnology-related strategies against melanoma - p. 385 25. Chapter 15 Challenges in the delivery of polyphenols to cancer cells - p. 425 26. Chapter 16 Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets - p. 441 27. Chapter 17 Therapeutic implications of targeting antioxidants to mitochondria - p. 459 28. Chapter 18 Nanomedicines and phytochemicals targeting Alzheimer’s disease - p. 477 29. Chapter 19 Mitochondria-targeted drugs and immune function - p. 499 30. Chapter 20 Polymeric drug delivery systems for mitigating oxidative stress - p. 525 31. Chapter 21 Polyphenols and the microbiota: A challenge in mitochondrial therapy - p. 541 32. Index - p. 557
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.
This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.
1. Mitochondrial Dysfunction and Nanotherapeutics - p. i 2. Cover - p. i 3. Title page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xix 8. About the editor - p. xxvii 9. Preface - p. xxix 10. Acknowledgments - p. xxxiii 11. Chapter 1 Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging - p. 1 12. Chapter 2 Mitochondrial dysfunction in inborn errors of metabolism - p. 35 13. Chapter 3 Impaired mitochondrial dynamics in disease - p. 57 14. Chapter 4 Mitochondrial dysfunction in metabolic disorders - p. 91 15. Chapter 5 Mitochondrial dysfunction and autophagy in neurodegeneration - p. 139 16. Chapter 6 Mitochondrial dysfunction in sepsis - p. 179 17. Chapter 7 Drug- or toxin-induced mitochondrial toxicity - p. 203 18. Chapter 8 Aging, mitochondria, and autophagy - p. 221 19. Chapter 9 Skin aging and mitochondria - p. 237 20. Chapter 10 Organelle targeting: Focus on the mitochondria - p. 261 21. Chapter 11 Nanotechnology, mitochondria, and cancer - p. 291 22. Chapter 12 Nanomaterials aimed toward the cardiac mitochondria: from therapeutics to nanosafety - p. 311 23. Chapter 13 Increasing resveratrol bioavailability: A therapeutic challenge focusing on the mitochondria - p. 349 24. Chapter 14 Advances in nanotechnology-related strategies against melanoma - p. 385 25. Chapter 15 Challenges in the delivery of polyphenols to cancer cells - p. 425 26. Chapter 16 Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets - p. 441 27. Chapter 17 Therapeutic implications of targeting antioxidants to mitochondria - p. 459 28. Chapter 18 Nanomedicines and phytochemicals targeting Alzheimer’s disease - p. 477 29. Chapter 19 Mitochondria-targeted drugs and immune function - p. 499 30. Chapter 20 Polymeric drug delivery systems for mitigating oxidative stress - p. 525 31. Chapter 21 Polyphenols and the microbiota: A challenge in mitochondrial therapy - p. 541 32. Index - p. 557
