American Trypanosomiasis, Chagas Disease: One Hundred Years of Research, Second Edition, provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease, the host, the insect vectors, and the causative parasite.
In addition, new insights on the molecular biology and diagnostics of Chagas diseases, the persistence of infections in the host, and the interaction of the parasite and host metabolism are now included in this new and updated edition.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xv 6. Preface - p. xix 7. 1. History of the discovery of the American Trypanosomiasis (Chagas disease) - p. 1 8. 2. Chagas disease in pre-Colombian civilizations - p. 23 9. 3. Social and medical aspects on Chagas disease management and control - p. 47 10. 4. Current epidemiological trends of Chagas disease in Latin America and future challenges: epidemiology, surveillance, and health policies - p. 59 11. 5. Geographical distribution of Chagas disease - p. 89 12. 6. Classification and systematics of the Triatominae - p. 113 13. 7. Biology of Triatominae - p. 145 14. 8. Population genetics of Triatominae - p. 169 15. 9. Geographic distribution of Triatominae vectors in America - p. 197 16. 10. Control strategies against Triatominae - p. 223 17. 11. Ecological aspects of Trypanosoma cruzi: Wild hosts and reservoirs - p. 243 18. 12. Trypanosoma cruzi enzootic cycle: General aspects, domestic and synanthropic hosts and reservoirs - p. 265 19. 13. Veterinary aspects - p. 283 20. 14. Experimental studies of Chagas disease in animal models - p. 299 21. 15. Classification and phylogeny of Trypanosoma cruzi - p. 321 22. 16. Biology of Trypanosoma cruzi and biological diversity - p. 345 23. 17. Biochemistry of Trypanosoma cruzi - p. 371 24. 18. Ultrastructure of Trypanosoma cruzi and its interaction with host cells - p. 401 25. 19. Genetics of Trypanosoma cruzi - p. 429 26. 20. Experimental and natural recombination in Trypanosoma cruzi - p. 455 27. 21. Trypanosoma cruzi and the model of predominant clonal evolution - p. 475 28. 22. Vector transmission: How it works, what transmits, where it occurs - p. 497 29. 23. Maternal–fetal transmission of Trypanosoma cruzi - p. 517 30. 24. Other forms of transmission: Blood transfusion, organ transplantation, laboratory accidents, oral and sexual transmission - p. 561 31. 25. Protective host response to Trypanosoma cruzi and its limitations - p. 579 32. 26. Cell invasion by Trypanosoma cruzi and the type I interferon response - p. 605 33. 27. Human genetic susceptibility to Chagas disease - p. 629 34. 28. Clinical phases and forms of Chagas disease - p. 653 35. 29. Diagnosis of Trypanosoma cruzi infection - p. 687 36. 30. AIDS and Chagas’ disease - p. 731 37. 31. Treatment of Chagas disease - p. 751 38. 32. Vaccine development for Chagas disease - p. 773 39. Index - p. 797
American Trypanosomiasis, Chagas Disease: One Hundred Years of Research, Second Edition, provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease, the host, the insect vectors, and the causative parasite.
In addition, new insights on the molecular biology and diagnostics of Chagas diseases, the persistence of infections in the host, and the interaction of the parasite and host metabolism are now included in this new and updated edition.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xv 6. Preface - p. xix 7. 1. History of the discovery of the American Trypanosomiasis (Chagas disease) - p. 1 8. 2. Chagas disease in pre-Colombian civilizations - p. 23 9. 3. Social and medical aspects on Chagas disease management and control - p. 47 10. 4. Current epidemiological trends of Chagas disease in Latin America and future challenges: epidemiology, surveillance, and health policies - p. 59 11. 5. Geographical distribution of Chagas disease - p. 89 12. 6. Classification and systematics of the Triatominae - p. 113 13. 7. Biology of Triatominae - p. 145 14. 8. Population genetics of Triatominae - p. 169 15. 9. Geographic distribution of Triatominae vectors in America - p. 197 16. 10. Control strategies against Triatominae - p. 223 17. 11. Ecological aspects of Trypanosoma cruzi: Wild hosts and reservoirs - p. 243 18. 12. Trypanosoma cruzi enzootic cycle: General aspects, domestic and synanthropic hosts and reservoirs - p. 265 19. 13. Veterinary aspects - p. 283 20. 14. Experimental studies of Chagas disease in animal models - p. 299 21. 15. Classification and phylogeny of Trypanosoma cruzi - p. 321 22. 16. Biology of Trypanosoma cruzi and biological diversity - p. 345 23. 17. Biochemistry of Trypanosoma cruzi - p. 371 24. 18. Ultrastructure of Trypanosoma cruzi and its interaction with host cells - p. 401 25. 19. Genetics of Trypanosoma cruzi - p. 429 26. 20. Experimental and natural recombination in Trypanosoma cruzi - p. 455 27. 21. Trypanosoma cruzi and the model of predominant clonal evolution - p. 475 28. 22. Vector transmission: How it works, what transmits, where it occurs - p. 497 29. 23. Maternal–fetal transmission of Trypanosoma cruzi - p. 517 30. 24. Other forms of transmission: Blood transfusion, organ transplantation, laboratory accidents, oral and sexual transmission - p. 561 31. 25. Protective host response to Trypanosoma cruzi and its limitations - p. 579 32. 26. Cell invasion by Trypanosoma cruzi and the type I interferon response - p. 605 33. 27. Human genetic susceptibility to Chagas disease - p. 629 34. 28. Clinical phases and forms of Chagas disease - p. 653 35. 29. Diagnosis of Trypanosoma cruzi infection - p. 687 36. 30. AIDS and Chagas’ disease - p. 731 37. 31. Treatment of Chagas disease - p. 751 38. 32. Vaccine development for Chagas disease - p. 773 39. Index - p. 797
