Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read.
Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. xiii 7. Preface - p. xix 8. Chapter 1: Role of animal research in human malignancies - p. xx 9. Chapter 2: Preclinical models in ovarian cancer - p. 29 10. Chapter 3: Animal models of cancer-associated cachexia - p. 57 11. Chapter 4: Imaging tools to enhance animal tumor models for cancer research and drug discovery - p. 74 12. Chapter 5: Protocols in genetic mice models of pancreatic cancer - p. 106 13. Chapter 6: Chemo-prevention and interception of obesity-promoted pancreatic ductal adenocarcinoma - p. 123 14. Chapter 7: Animal models of primary brain tumors - p. 147 15. Chapter 8: Metastatic brain tumor models and drug brain penetration analysis - p. 194 16. Chapter 9: A guide to tumor assessment methodologies in cancer drug discovery - p. 232 17. Chapter 10: Mouse models of pancreatic cancer: An ever-emerging arm of cancer drug discovery - p. 248 18. Chapter 11: Mouse models of gastrointestinal cancers in drug development and research - p. 266 19. Chapter 12: Preclinical animal tumor models to study prevention of colon cancer recurrence by curcumin - p. 292 20. Chapter 13: Role of 3D tissue engineering models for human cancer and drug development - p. 307 21. Chapter 14: Drug development using pancreatic and lung organoid models - p. 322 22. Chapter 15: Leveraging dogs with spontaneous cancer to advance drug development - p. 342 23. Chapter 16: Cancer imaging in preclinical models - p. 372 24. Chapter 17: Animal (mouse) models of melanoma - p. 400 25. Chapter 18: Animal mouse models of acute myeloid leukemia - p. 417 26. Index - p. 439
Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read.
Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. xiii 7. Preface - p. xix 8. Chapter 1: Role of animal research in human malignancies - p. xx 9. Chapter 2: Preclinical models in ovarian cancer - p. 29 10. Chapter 3: Animal models of cancer-associated cachexia - p. 57 11. Chapter 4: Imaging tools to enhance animal tumor models for cancer research and drug discovery - p. 74 12. Chapter 5: Protocols in genetic mice models of pancreatic cancer - p. 106 13. Chapter 6: Chemo-prevention and interception of obesity-promoted pancreatic ductal adenocarcinoma - p. 123 14. Chapter 7: Animal models of primary brain tumors - p. 147 15. Chapter 8: Metastatic brain tumor models and drug brain penetration analysis - p. 194 16. Chapter 9: A guide to tumor assessment methodologies in cancer drug discovery - p. 232 17. Chapter 10: Mouse models of pancreatic cancer: An ever-emerging arm of cancer drug discovery - p. 248 18. Chapter 11: Mouse models of gastrointestinal cancers in drug development and research - p. 266 19. Chapter 12: Preclinical animal tumor models to study prevention of colon cancer recurrence by curcumin - p. 292 20. Chapter 13: Role of 3D tissue engineering models for human cancer and drug development - p. 307 21. Chapter 14: Drug development using pancreatic and lung organoid models - p. 322 22. Chapter 15: Leveraging dogs with spontaneous cancer to advance drug development - p. 342 23. Chapter 16: Cancer imaging in preclinical models - p. 372 24. Chapter 17: Animal (mouse) models of melanoma - p. 400 25. Chapter 18: Animal mouse models of acute myeloid leukemia - p. 417 26. Index - p. 439
