Animal Models of Neurological Conditions informs about novel animal models and their unique strengths and limitations in the research of neurological conditions. It demonstrates the importance of animal models’ abilities to replicate only aspects of a given neurological condition and highlights the value of these animal models in increasing human brain function in afflicted patients. This book, comprised of thirteen chapters discusses various animal models and research methods for mental health, neurodevelopmental disorders, addiction, age-related neurodegenerative conditions, and viruses affecting brain function. Although developed with neuroscience researchers and trainees involved in pre-clinical and clinical research in mind, neurologists and other treatment professionals caring for patients with neurological conditions will also find value in this detailed resource.
This is an invaluable resource for neuroscience researchers, trainees, and healthcare professionals.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Preface - p. xvii 8. Acknowledgment - p. xxi 9. Section 1: Animal models of alcohol and drugs of abuse - p. S1 10. Chapter 1. Mouse behavioral models of alcohol and drug hedonic effects - p. 3 11. Chapter 2. Nonhuman primate models of fetal alcohol spectrum disorders - p. 27 12. Section 2: Posttraumatic stress disorder animal models - p. S53 13. Chapter 3. Rodent models of posttraumatic stress disorder - p. 55 14. Section 3: Animal models of traumatic brain injury - p. S95 15. Chapter 4. Mouse models of traumatic brain injury - p. 97 16. Section 4: Animal models of ischemic and vascular conditions - p. S123 17. Chapter 5. Sheep model of hypoxia to the developing brain - p. 125 18. Chapter 6. Animal models of ischemic and hemorrhagic stroke - p. 153 19. Chapter 7. Animal models of depression: a novel preclinical framework for post-myocardial infarction depression - p. 193 20. Section 5: Animal models of mild cognitive impairment - p. S229 21. Chapter 8. Nonhuman primate model of mild cognitive impairment - p. 231 22. Section 6: Parkinson’s disease animal models - p. S257 23. Chapter 9. MPTP progressive model of Parkinson’s disease: changes in basal ganglia circuitry and restorative treatment strategies - p. 259 24. Section 7: Alzheimer’s disease mouse models - p. S279 25. Chapter 10. Mouse models of Alzheimer’s disease pathology - p. 281 26. Chapter 11. Mouse models elucidating the role of apolipoprotein E in neurological conditions - p. 307 27. Section 8: Western Pacific ALS/PDC mouse models - p. S353 28. Chapter 12. Animal models of Western Pacific amyotrophic lateral sclerosis and Parkinsonism-dementia complex - p. 355 29. Section 9: Second-hand cigarette smoke rodent models - p. S385 30. Chapter 13. Animal models of second-hand cigarette smoke (SHS) exposure in neurodevelopmental disorders and neurodegenerative disease - p. 387 31. Section 10: Multiple sclerosis animal models - p. S413 32. Chapter 14. Nonhuman primate models of multiple sclerosis: advantages over rodent models for preclinical studies - p. 415 33. Section 11: Hepatitis mouse models - p. S431 34. Chapter 15. Animal models of hepatitis - p. 433 35. Index - p. 473
Animal Models of Neurological Conditions informs about novel animal models and their unique strengths and limitations in the research of neurological conditions. It demonstrates the importance of animal models’ abilities to replicate only aspects of a given neurological condition and highlights the value of these animal models in increasing human brain function in afflicted patients. This book, comprised of thirteen chapters discusses various animal models and research methods for mental health, neurodevelopmental disorders, addiction, age-related neurodegenerative conditions, and viruses affecting brain function. Although developed with neuroscience researchers and trainees involved in pre-clinical and clinical research in mind, neurologists and other treatment professionals caring for patients with neurological conditions will also find value in this detailed resource.
This is an invaluable resource for neuroscience researchers, trainees, and healthcare professionals.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xiii 7. Preface - p. xvii 8. Acknowledgment - p. xxi 9. Section 1: Animal models of alcohol and drugs of abuse - p. S1 10. Chapter 1. Mouse behavioral models of alcohol and drug hedonic effects - p. 3 11. Chapter 2. Nonhuman primate models of fetal alcohol spectrum disorders - p. 27 12. Section 2: Posttraumatic stress disorder animal models - p. S53 13. Chapter 3. Rodent models of posttraumatic stress disorder - p. 55 14. Section 3: Animal models of traumatic brain injury - p. S95 15. Chapter 4. Mouse models of traumatic brain injury - p. 97 16. Section 4: Animal models of ischemic and vascular conditions - p. S123 17. Chapter 5. Sheep model of hypoxia to the developing brain - p. 125 18. Chapter 6. Animal models of ischemic and hemorrhagic stroke - p. 153 19. Chapter 7. Animal models of depression: a novel preclinical framework for post-myocardial infarction depression - p. 193 20. Section 5: Animal models of mild cognitive impairment - p. S229 21. Chapter 8. Nonhuman primate model of mild cognitive impairment - p. 231 22. Section 6: Parkinson’s disease animal models - p. S257 23. Chapter 9. MPTP progressive model of Parkinson’s disease: changes in basal ganglia circuitry and restorative treatment strategies - p. 259 24. Section 7: Alzheimer’s disease mouse models - p. S279 25. Chapter 10. Mouse models of Alzheimer’s disease pathology - p. 281 26. Chapter 11. Mouse models elucidating the role of apolipoprotein E in neurological conditions - p. 307 27. Section 8: Western Pacific ALS/PDC mouse models - p. S353 28. Chapter 12. Animal models of Western Pacific amyotrophic lateral sclerosis and Parkinsonism-dementia complex - p. 355 29. Section 9: Second-hand cigarette smoke rodent models - p. S385 30. Chapter 13. Animal models of second-hand cigarette smoke (SHS) exposure in neurodevelopmental disorders and neurodegenerative disease - p. 387 31. Section 10: Multiple sclerosis animal models - p. S413 32. Chapter 14. Nonhuman primate models of multiple sclerosis: advantages over rodent models for preclinical studies - p. 415 33. Section 11: Hepatitis mouse models - p. S431 34. Chapter 15. Animal models of hepatitis - p. 433 35. Index - p. 473
