Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm.
This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.
1. Anti-Aging Pharmacology - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Preface - p. xvii 9. Acknowledgments - p. xix 10. Chapter 1 Geroscience—the concept - p. 1 11. Chapter 2 Basic pathways and targets for anti-aging intervention - p. 13 12. Chapter 3 Omics approaches in aging research - p. 41 13. Chapter 4 Metformin - p. 71 14. Chapter 5 Rapamycin and rapalogs - p. 89 15. Chapter 6 Anti-aging effects of phenolic compounds - p. 119 16. Chapter 7 Curcumin - p. 153 17. Chapter 8 Pharmacology of NAD+ boosters - p. 177 18. Chapter 9 Mitochondrial modulators - p. 193 19. Chapter 10 Nonsteroidal anti-inflammatory drugs - p. 227 20. Chapter 11 Senolytics in diseases - p. 245 21. Chapter 12 Anti-aging skincare - p. 269 22. Chapter 13 Protein kinase modulation for anti-aging intervention - p. 285 23. Chapter 14 The anti-aging mechanism of Berberine associated with metabolic control - p. 305 24. Chapter 15 Growth hormone - p. 329 25. Chapter 16 Antioxidant pharmacology - p. 341 26. Afterword: conclusions and outlook - p. 367 27. Index - p. 373
Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm.
This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.
1. Anti-Aging Pharmacology - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Contributors - p. xiii 8. Preface - p. xvii 9. Acknowledgments - p. xix 10. Chapter 1 Geroscience—the concept - p. 1 11. Chapter 2 Basic pathways and targets for anti-aging intervention - p. 13 12. Chapter 3 Omics approaches in aging research - p. 41 13. Chapter 4 Metformin - p. 71 14. Chapter 5 Rapamycin and rapalogs - p. 89 15. Chapter 6 Anti-aging effects of phenolic compounds - p. 119 16. Chapter 7 Curcumin - p. 153 17. Chapter 8 Pharmacology of NAD+ boosters - p. 177 18. Chapter 9 Mitochondrial modulators - p. 193 19. Chapter 10 Nonsteroidal anti-inflammatory drugs - p. 227 20. Chapter 11 Senolytics in diseases - p. 245 21. Chapter 12 Anti-aging skincare - p. 269 22. Chapter 13 Protein kinase modulation for anti-aging intervention - p. 285 23. Chapter 14 The anti-aging mechanism of Berberine associated with metabolic control - p. 305 24. Chapter 15 Growth hormone - p. 329 25. Chapter 16 Antioxidant pharmacology - p. 341 26. Afterword: conclusions and outlook - p. 367 27. Index - p. 373
