Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures.
The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host.
These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.
1. Introduction - p. 59 2. The Genetic Basis of Vector Competence and Its Link to Mosquito Immunity - p. 61 3. Current Knowledge of Antiparasite Immune Reactions in the Mosquito Vector - p. 62 4. The Regulation of Anti-Parasite Immunity by Canonical Signal Transduction Pathways - p. 67 5. Creating Malaria-Refractory Mosquitoes in the Laboratory: The Proof of Principle - p. 75 6. The Challenges and Opportunities for Boosting Mosquito Immunity in the Field - p. 80 7. Chapter 5. Molecular Mechanisms Mediating Immune Priming in Anopheles gambiae Mosquitoes - p. 91 8. Chapter 6. The Mosquito Immune System and Its Interactions With the Microbiota: Implications for Disease Transmission - p. 101 9. Chapter 7. Using an Endosymbiont to Control Mosquito-Transmitted Disease - p. 123 10. Chapter 8. Effect of Host Blood–Derived Antibodies Targeting Critical Mosquito Neuronal Receptors and Other Proteins: Disruption of Vector Physiology and Potential for Disease Control - p. 143 11. Chapter 9. Role of the Microbiota During Development of the Arthropod Vector Immune System - p. 161 12. Chapter 10. Host–Microbe Interactions: A Case for Wolbachia Dialogue - p. 173 13. Chapter 11. The Gut Microbiota of Mosquitoes: Diversity and Function - p. 185 14. Chapter 12. Targeting Dengue Virus Replication in Mosquitoes - p. 201 15. Chapter 13. Paratransgenesis Applications: Fighting Malaria With Engineered Mosquito Symbiotic Bacteria - p. 219 16. Chapter 14. Insulin-Like Peptides Regulate Plasmodium falciparum Infection in Anopheles stephensi - p. 235 17. Index - p. 249
Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures.
The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host.
These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.
1. Introduction - p. 59 2. The Genetic Basis of Vector Competence and Its Link to Mosquito Immunity - p. 61 3. Current Knowledge of Antiparasite Immune Reactions in the Mosquito Vector - p. 62 4. The Regulation of Anti-Parasite Immunity by Canonical Signal Transduction Pathways - p. 67 5. Creating Malaria-Refractory Mosquitoes in the Laboratory: The Proof of Principle - p. 75 6. The Challenges and Opportunities for Boosting Mosquito Immunity in the Field - p. 80 7. Chapter 5. Molecular Mechanisms Mediating Immune Priming in Anopheles gambiae Mosquitoes - p. 91 8. Chapter 6. The Mosquito Immune System and Its Interactions With the Microbiota: Implications for Disease Transmission - p. 101 9. Chapter 7. Using an Endosymbiont to Control Mosquito-Transmitted Disease - p. 123 10. Chapter 8. Effect of Host Blood–Derived Antibodies Targeting Critical Mosquito Neuronal Receptors and Other Proteins: Disruption of Vector Physiology and Potential for Disease Control - p. 143 11. Chapter 9. Role of the Microbiota During Development of the Arthropod Vector Immune System - p. 161 12. Chapter 10. Host–Microbe Interactions: A Case for Wolbachia Dialogue - p. 173 13. Chapter 11. The Gut Microbiota of Mosquitoes: Diversity and Function - p. 185 14. Chapter 12. Targeting Dengue Virus Replication in Mosquitoes - p. 201 15. Chapter 13. Paratransgenesis Applications: Fighting Malaria With Engineered Mosquito Symbiotic Bacteria - p. 219 16. Chapter 14. Insulin-Like Peptides Regulate Plasmodium falciparum Infection in Anopheles stephensi - p. 235 17. Index - p. 249
