Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Any screen, Any time, Anywhere - p. iii 5. Title page - p. IFC1 6. Copyright - p. IFC1 7. Contributors - p. IFC1 8. Preface - p. IFC1 9. Foreword - p. iv 10. Acknowledgment - p. vii 11. Contents - p. viii 12. Section I: A History of Atopy - p. viii 13. List of Tables - p. viii 14. Chapter 1: Historic Perspective - p. viii 15. Chapter 2: Atopy Redefined - p. 8 16. Chapter 3: Atopy of the Skin - p. 14 17. Chapter 4: Epidemiology - p. 22 18. Section II: External Factors - p. 31 19. Chapter 5: Skin Barrier - p. 31 20. Chapter 6: Skin and Gut Microbiome - p. 41 21. Chapter 7: Immunogens - p. 51 22. Chapter 8: Nutrition - p. 64 23. Chapter 9: Oxidative Stress, Environmental Factors, and Pollutants - p. 74 24. Chapter 10: Clinical Evidence: External Factors - p. 83 25. Section III: Internal Factors - p. 88 26. Chapter 11: Keratinocytes - p. 88 27. Chapter 12: Microvasculature - p. 100 28. Chapter 13: Humoral Factors - p. 119 29. Chapter 14: Cellular Factors - p. 130 30. Chapter 15: Skin-Gut-Lung Epithelial Permeability - p. 141 31. Chapter 16: Neurosensory Mechanisms - p. 155 32. Chapter 17: Epigenetics - p. 165 33. Chapter 18: Clinical Evidence: Internal Factors - p. 175 34. Section IV: Clinician’s Corner - p. 184 35. Chapter 19: Therapeutic Guideline Overview - p. 184 36. Chapter 20: Topical Therapies - p. 196 37. Chapter 21: Wound Care - p. 205 38. Chapter 22: Skin Barrier Repair - p. 218 39. Chapter 23: Emerging Targeted Treatments - p. 233 40. Chapter 24: Microbiome Modulation - p. 246 41. Chapter 25: Itch and Pain Treatments - p. 259 42. Chapter 26: Complementary and Alternative Approaches I - p. 271 43. Chapter 27: Complementary and Alternative Approaches II - p. 283 44. Glossary - p. 291 45. Bibliography - p. 291 46. Index - p. 291 47. Confidence is ClinicalKey - p. 291
Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Any screen, Any time, Anywhere - p. iii 5. Title page - p. IFC1 6. Copyright - p. IFC1 7. Contributors - p. IFC1 8. Preface - p. IFC1 9. Foreword - p. iv 10. Acknowledgment - p. vii 11. Contents - p. viii 12. Section I: A History of Atopy - p. viii 13. List of Tables - p. viii 14. Chapter 1: Historic Perspective - p. viii 15. Chapter 2: Atopy Redefined - p. 8 16. Chapter 3: Atopy of the Skin - p. 14 17. Chapter 4: Epidemiology - p. 22 18. Section II: External Factors - p. 31 19. Chapter 5: Skin Barrier - p. 31 20. Chapter 6: Skin and Gut Microbiome - p. 41 21. Chapter 7: Immunogens - p. 51 22. Chapter 8: Nutrition - p. 64 23. Chapter 9: Oxidative Stress, Environmental Factors, and Pollutants - p. 74 24. Chapter 10: Clinical Evidence: External Factors - p. 83 25. Section III: Internal Factors - p. 88 26. Chapter 11: Keratinocytes - p. 88 27. Chapter 12: Microvasculature - p. 100 28. Chapter 13: Humoral Factors - p. 119 29. Chapter 14: Cellular Factors - p. 130 30. Chapter 15: Skin-Gut-Lung Epithelial Permeability - p. 141 31. Chapter 16: Neurosensory Mechanisms - p. 155 32. Chapter 17: Epigenetics - p. 165 33. Chapter 18: Clinical Evidence: Internal Factors - p. 175 34. Section IV: Clinician’s Corner - p. 184 35. Chapter 19: Therapeutic Guideline Overview - p. 184 36. Chapter 20: Topical Therapies - p. 196 37. Chapter 21: Wound Care - p. 205 38. Chapter 22: Skin Barrier Repair - p. 218 39. Chapter 23: Emerging Targeted Treatments - p. 233 40. Chapter 24: Microbiome Modulation - p. 246 41. Chapter 25: Itch and Pain Treatments - p. 259 42. Chapter 26: Complementary and Alternative Approaches I - p. 271 43. Chapter 27: Complementary and Alternative Approaches II - p. 283 44. Glossary - p. 291 45. Bibliography - p. 291 46. Index - p. 291 47. Confidence is ClinicalKey - p. 291
