Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Any screen, Any time, Anywhere - p. iii 5. Copyright - p. iv 6. Contributors - p. iv 7. Preface - p. vi 8. Foreword - p. vii 9. Acknowledgment - p. viii 10. Section I: A History of Atopy - p. ix 11. 1. Historic Perspective - p. 1 12. 2. Atopy Redefined - p. 10 13. 3. Atopy of the Skin - p. 17 14. 4. Epidemiology - p. 25 15. Section II: External Factors - p. 31 16. 5. Skin Barrier - p. 34 17. 6. Skin and Gut Microbiome - p. 44 18. 7. Immunogens - p. 56 19. 8. Nutrition - p. 67 20. 9. Oxidative Stress, Environmental Factors, and Pollutants - p. 79 21. 10. Clinical Evidence: External Factors - p. 85 22. Section III: Internal Factors - p. 88 23. 11. Keratinocytes - p. 90 24. 12. Microvasculature - p. 106 25. 13. Humoral Factors - p. 123 26. 14. Cellular Factors - p. 134 27. 15. Skin-Gut-Lung Epithelial Permeability - p. 146 28. 16. Neurosensory Mechanisms - p. 159 29. 17. Epigenetics - p. 168 30. 18. Clinical Evidence: Internal Factors - p. 179 31. Section IV: Clinician’s Corner - p. 184 32. 19. Therapeutic Guideline Overview - p. 188 33. 20. Topical Therapies - p. 197 34. 21. Wound Care - p. 209 35. 22. Skin Barrier Repair - p. 226 36. 23. Emerging Targeted Treatments - p. 237 37. 24. Microbiome Modulation - p. 252 38. 25. Itch and Pain Treatments - p. 264 39. 26. Complementary and Alternative Approaches I - p. 276 40. 27. Complementary and Alternative Approaches II - p. 287 41. Glossary - p. 293 42. Bibliography - p. 297 43. Index - p. 298 44. Confidence is ClinicalKey - p. 304
Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Any screen, Any time, Anywhere - p. iii 5. Copyright - p. iv 6. Contributors - p. iv 7. Preface - p. vi 8. Foreword - p. vii 9. Acknowledgment - p. viii 10. Section I: A History of Atopy - p. ix 11. 1. Historic Perspective - p. 1 12. 2. Atopy Redefined - p. 10 13. 3. Atopy of the Skin - p. 17 14. 4. Epidemiology - p. 25 15. Section II: External Factors - p. 31 16. 5. Skin Barrier - p. 34 17. 6. Skin and Gut Microbiome - p. 44 18. 7. Immunogens - p. 56 19. 8. Nutrition - p. 67 20. 9. Oxidative Stress, Environmental Factors, and Pollutants - p. 79 21. 10. Clinical Evidence: External Factors - p. 85 22. Section III: Internal Factors - p. 88 23. 11. Keratinocytes - p. 90 24. 12. Microvasculature - p. 106 25. 13. Humoral Factors - p. 123 26. 14. Cellular Factors - p. 134 27. 15. Skin-Gut-Lung Epithelial Permeability - p. 146 28. 16. Neurosensory Mechanisms - p. 159 29. 17. Epigenetics - p. 168 30. 18. Clinical Evidence: Internal Factors - p. 179 31. Section IV: Clinician’s Corner - p. 184 32. 19. Therapeutic Guideline Overview - p. 188 33. 20. Topical Therapies - p. 197 34. 21. Wound Care - p. 209 35. 22. Skin Barrier Repair - p. 226 36. 23. Emerging Targeted Treatments - p. 237 37. 24. Microbiome Modulation - p. 252 38. 25. Itch and Pain Treatments - p. 264 39. 26. Complementary and Alternative Approaches I - p. 276 40. 27. Complementary and Alternative Approaches II - p. 287 41. Glossary - p. 293 42. Bibliography - p. 297 43. Index - p. 298 44. Confidence is ClinicalKey - p. 304
