Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms.
1. Introduction - p. 1 2. Specific Functions of Autophagy (A Summary) - p. 15 3. Autophagy Process - p. 16 4. Autophagy in Normal Mammalian Cells - p. 16 5. Endoplasmic Reticulum - p. 18 6. Major Types of Autophagies - p. 21 7. Autophagosome Formation - p. 22 8. Autophagic Flux - p. 24 9. Autophagic Lysosome Reformation - p. 24 10. Autophagy as a Double-Edged Sword - p. 25 11. Protein Synthesis - p. 26 12. Autophagic Proteins - p. 35 13. Ubiquitin-Proteasome System - p. 38 14. Aggrephagy–Autophagy System - p. 39 15. Aggresome, Ubiquitin Proteasome, and Autophagic Systems - p. 41 16. Monitoring Autophagy - p. 41 17. Reactive Oxygen Species - p. 42 18. Mammalian (Mechanistic) Target of Rapamycin - p. 43 19. Role of Autophagy in Tumorigenesis and Cancer - p. 46 20. Immunotherapy and Tumor Microenvironment - p. 48 21. Autophagy and Immune System - p. 49 22. Autophagy and Warburg Effect - p. 50 23. Autophagy and Senescence - p. 52 24. Role of Autophagy and Cellular Senescence in Aging - p. 53 25. Role of Autophagy in Heart Disease and Aging - p. 55 26. Autophagy in Stem Cells - p. 62 27. Role of Autophagy in Viral Infection - p. 66 28. Role of Autophagy in Bacterial Infection - p. 67 29. Cross-Talk Between Autophagy and Apoptosis - p. 68 30. Autophagy and Ubiquitination - p. 72 31. Autophagy and Necroptosis - p. 73 32. Mitochondrial Fusion and Fission - p. 73 33. Selective Autophagy - p. 74 34. References - p. 100 35. Chapter 2. The Role of Autophagy in Aging: Molecular Mechanisms - p. 123 36. Chapter 3. The Role of p62 in Aggregopathies - p. 139 37. Chapter 4. Role of Autophagy in the Transition From Monocyte to Differentiation - p. 149 38. Chapter 5. Cdc48 AAA ATPase Regulates Protein Dynamics and Turnover in Mitochondria - p. 161 39. Chapter 6. Autophagy in Plasma Cells - p. 175 40. Chapter 7. Loss of PINK1 or Parkin Function Results in a Progressive Loss of Mitochondrial Function - p. 187 41. Chapter 8. Role of the Transcription Factor Interferon Regulatory Factor-1 in Regulating Autophagy in Lipopolysaccharide-Stimulated Macrophages - p. 211 42. Chapter 9. Mechanistic Target of Rapamycin: The Alpha and Omega of Autophagy Regulation - p. 231 43. Chapter 10. ER-Phagy in Starvation, ER Stress, and Quality Control - p. 251 44. Chapter 11. Role of Autophagy Inhibition in Tumor Proliferative Arrest - p. 261 45. Chapter 12. Survival at the Brink: Chromatin Autophagy of Tumor Cells in Response to Genotoxic Challenge - p. 275 46. Chapter 13. Loss of Autophagy in Hypothalamic Neurons May Be Involved in the Pathogenesis of Obesity - p. 295 47. Chapter 14. Defective Autophagy in Mesenteric Fat Tissue Maintains Inflammation in Crohn’s Disease - p. 313 48. Chapter 15. Autophagy Regulates Inflammatory Responses in Antigen-Presenting Cells: Underlying Mechanisms - p. 325 49. Chapter 16. Autophagy Accompanies Inflammasome Activation to Moderate Inflammation by Eliminating Active Inflammasomes - p. 343 50. Chapter 17. Autophagy, Inflammation, and Breast Cancer Risk - p. 359 51. Chapter 18. AMBRA1-Mediated Regulation of C-MYC and Its Relevance to Cancer - p. 373 52. Chapter 19. The Delicate Balance of Autophagy in Neurodegeneration - p. 387 53. Chapter 20. Silibinin Protects Ultraviolet B–Irradiated Skin by Balancing Apoptosis and Autophagy in Epidermis and Dermis - p. 401 54. Chapter 21. Role of Autophagy Activation in Alleviating Alcohol Neurotoxicity - p. 419 55. Chapter 22. Lipopolysaccharide-Enhanced Bactericidal Activity is Mediated by Induction of the Autophagosomal Process - p. 435 56. Chapter 23. Role of Autophagy in Liver Regeneration - p. 451 57. Chapter 24. A Dual Role of a Soluble N-Ethylmaleimide Sensitive Factor–Attachment Protein Alpha (αSNAP) in the Regulation of Autophagy - p. 463 58. Chapter 25. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induces Autophagic Protein Cleavage in Melanoma Cells - p. 473 59. Abbreviations and Glossary - p. 489 60. Index - p. 503
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms.
1. Introduction - p. 1 2. Specific Functions of Autophagy (A Summary) - p. 15 3. Autophagy Process - p. 16 4. Autophagy in Normal Mammalian Cells - p. 16 5. Endoplasmic Reticulum - p. 18 6. Major Types of Autophagies - p. 21 7. Autophagosome Formation - p. 22 8. Autophagic Flux - p. 24 9. Autophagic Lysosome Reformation - p. 24 10. Autophagy as a Double-Edged Sword - p. 25 11. Protein Synthesis - p. 26 12. Autophagic Proteins - p. 35 13. Ubiquitin-Proteasome System - p. 38 14. Aggrephagy–Autophagy System - p. 39 15. Aggresome, Ubiquitin Proteasome, and Autophagic Systems - p. 41 16. Monitoring Autophagy - p. 41 17. Reactive Oxygen Species - p. 42 18. Mammalian (Mechanistic) Target of Rapamycin - p. 43 19. Role of Autophagy in Tumorigenesis and Cancer - p. 46 20. Immunotherapy and Tumor Microenvironment - p. 48 21. Autophagy and Immune System - p. 49 22. Autophagy and Warburg Effect - p. 50 23. Autophagy and Senescence - p. 52 24. Role of Autophagy and Cellular Senescence in Aging - p. 53 25. Role of Autophagy in Heart Disease and Aging - p. 55 26. Autophagy in Stem Cells - p. 62 27. Role of Autophagy in Viral Infection - p. 66 28. Role of Autophagy in Bacterial Infection - p. 67 29. Cross-Talk Between Autophagy and Apoptosis - p. 68 30. Autophagy and Ubiquitination - p. 72 31. Autophagy and Necroptosis - p. 73 32. Mitochondrial Fusion and Fission - p. 73 33. Selective Autophagy - p. 74 34. References - p. 100 35. Chapter 2. The Role of Autophagy in Aging: Molecular Mechanisms - p. 123 36. Chapter 3. The Role of p62 in Aggregopathies - p. 139 37. Chapter 4. Role of Autophagy in the Transition From Monocyte to Differentiation - p. 149 38. Chapter 5. Cdc48 AAA ATPase Regulates Protein Dynamics and Turnover in Mitochondria - p. 161 39. Chapter 6. Autophagy in Plasma Cells - p. 175 40. Chapter 7. Loss of PINK1 or Parkin Function Results in a Progressive Loss of Mitochondrial Function - p. 187 41. Chapter 8. Role of the Transcription Factor Interferon Regulatory Factor-1 in Regulating Autophagy in Lipopolysaccharide-Stimulated Macrophages - p. 211 42. Chapter 9. Mechanistic Target of Rapamycin: The Alpha and Omega of Autophagy Regulation - p. 231 43. Chapter 10. ER-Phagy in Starvation, ER Stress, and Quality Control - p. 251 44. Chapter 11. Role of Autophagy Inhibition in Tumor Proliferative Arrest - p. 261 45. Chapter 12. Survival at the Brink: Chromatin Autophagy of Tumor Cells in Response to Genotoxic Challenge - p. 275 46. Chapter 13. Loss of Autophagy in Hypothalamic Neurons May Be Involved in the Pathogenesis of Obesity - p. 295 47. Chapter 14. Defective Autophagy in Mesenteric Fat Tissue Maintains Inflammation in Crohn’s Disease - p. 313 48. Chapter 15. Autophagy Regulates Inflammatory Responses in Antigen-Presenting Cells: Underlying Mechanisms - p. 325 49. Chapter 16. Autophagy Accompanies Inflammasome Activation to Moderate Inflammation by Eliminating Active Inflammasomes - p. 343 50. Chapter 17. Autophagy, Inflammation, and Breast Cancer Risk - p. 359 51. Chapter 18. AMBRA1-Mediated Regulation of C-MYC and Its Relevance to Cancer - p. 373 52. Chapter 19. The Delicate Balance of Autophagy in Neurodegeneration - p. 387 53. Chapter 20. Silibinin Protects Ultraviolet B–Irradiated Skin by Balancing Apoptosis and Autophagy in Epidermis and Dermis - p. 401 54. Chapter 21. Role of Autophagy Activation in Alleviating Alcohol Neurotoxicity - p. 419 55. Chapter 22. Lipopolysaccharide-Enhanced Bactericidal Activity is Mediated by Induction of the Autophagosomal Process - p. 435 56. Chapter 23. Role of Autophagy in Liver Regeneration - p. 451 57. Chapter 24. A Dual Role of a Soluble N-Ethylmaleimide Sensitive Factor–Attachment Protein Alpha (αSNAP) in the Regulation of Autophagy - p. 463 58. Chapter 25. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Induces Autophagic Protein Cleavage in Melanoma Cells - p. 473 59. Abbreviations and Glossary - p. 489 60. Index - p. 503
