Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches along with certain key topics related to molecular pharmacology of drugs and therapeutics.
Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology. It explains the phenomena of drug-target interactions considering different biochemical systems and cellular strategies. With the advent of technologies, current advances and research trends move toward molecular and/or target-based drug design and discovery.
Through this book, readers will be able to gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology, in a comprehensive and systematic manner with special reference to recent advances in drug discovery research.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xi 7. Section I: Biochemical and molecular aspects - p. xiv 8. Chapter 1. Structures and functions of biomolecules - p. 3 9. Chapter 2. Pharmacokinetics and pharmacodynamics - p. 21 10. Chapter 3. Overview of drugs and drug targets - p. 45 11. Chapter 4. Nucleic acids as drug targets - p. 71 12. Chapter 5. Molecular cloning of drug targets - p. 99 13. Chapter 6. Pharmacogenetics and pharmacogenomics: Role of pharmacogenomics in drug discovery and development - p. 121 14. Chapter 7. Drug receptor interactions - p. 139 15. Chapter 8. Enzymology in drug discovery - p. 151 16. Chapter 9. Targeting epitranscriptomics for novel drug development - p. 167 17. Chapter 10. Applications of molecular pharmacology in drug discovery - p. 197 18. Section II: Drug design and discovery - p. 235 19. Chapter 11. Fundamentals of drug design and discovery - p. 239 20. Chapter 12. Fundamental approaches of drug discovery - p. 251 21. Chapter 13. Enzyme inhibitors: Design of kinase inhibitors as anticancer drugs - p. 283 22. Chapter 14. Reverse pharmacology and drug repositioning in drug discovery - p. 297 23. Chapter 15. Bioinformatics and CADD approaches in drug discovery - p. 313 24. Chapter 16. Artificial intelligence-based protein structure prediction and systems biology-guided smart drug screening - p. 323 25. Chapter 17. Recombinant DNA technology and gene therapy - p. 353 26. Chapter 18. Gut-health pharmacology: Integrating microbiota insights with natural product based therapies - p. 377 27. Section III: Key aspects of molecular pharmacology - p. 399 28. Chapter 19. Neuropharmacology and neurotherapeutics: Advancing the understanding and treatment of neurological disorders - p. 403 29. Chapter 20. Molecular oncobiology and cancer chemotherapeutics - p. 427 30. Chapter 21. Molecular inflammopharmacology and therapeutics - p. 455 31. Chapter 22. Molecular cardiopharmacology and Therapeutics-I - p. 471 32. Chapter 23. Molecular cardiopharmacology and therapeutics-II - p. 487 33. Chapter 24. Molecular endocrine pharmacology and therapeutics - p. 503 34. Chapter 25. Molecular viral infections and antiviral therapeutics - p. 515 35. Index - p. 541
Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches along with certain key topics related to molecular pharmacology of drugs and therapeutics.
Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology. It explains the phenomena of drug-target interactions considering different biochemical systems and cellular strategies. With the advent of technologies, current advances and research trends move toward molecular and/or target-based drug design and discovery.
Through this book, readers will be able to gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology, in a comprehensive and systematic manner with special reference to recent advances in drug discovery research.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xi 7. Section I: Biochemical and molecular aspects - p. xiv 8. Chapter 1. Structures and functions of biomolecules - p. 3 9. Chapter 2. Pharmacokinetics and pharmacodynamics - p. 21 10. Chapter 3. Overview of drugs and drug targets - p. 45 11. Chapter 4. Nucleic acids as drug targets - p. 71 12. Chapter 5. Molecular cloning of drug targets - p. 99 13. Chapter 6. Pharmacogenetics and pharmacogenomics: Role of pharmacogenomics in drug discovery and development - p. 121 14. Chapter 7. Drug receptor interactions - p. 139 15. Chapter 8. Enzymology in drug discovery - p. 151 16. Chapter 9. Targeting epitranscriptomics for novel drug development - p. 167 17. Chapter 10. Applications of molecular pharmacology in drug discovery - p. 197 18. Section II: Drug design and discovery - p. 235 19. Chapter 11. Fundamentals of drug design and discovery - p. 239 20. Chapter 12. Fundamental approaches of drug discovery - p. 251 21. Chapter 13. Enzyme inhibitors: Design of kinase inhibitors as anticancer drugs - p. 283 22. Chapter 14. Reverse pharmacology and drug repositioning in drug discovery - p. 297 23. Chapter 15. Bioinformatics and CADD approaches in drug discovery - p. 313 24. Chapter 16. Artificial intelligence-based protein structure prediction and systems biology-guided smart drug screening - p. 323 25. Chapter 17. Recombinant DNA technology and gene therapy - p. 353 26. Chapter 18. Gut-health pharmacology: Integrating microbiota insights with natural product based therapies - p. 377 27. Section III: Key aspects of molecular pharmacology - p. 399 28. Chapter 19. Neuropharmacology and neurotherapeutics: Advancing the understanding and treatment of neurological disorders - p. 403 29. Chapter 20. Molecular oncobiology and cancer chemotherapeutics - p. 427 30. Chapter 21. Molecular inflammopharmacology and therapeutics - p. 455 31. Chapter 22. Molecular cardiopharmacology and Therapeutics-I - p. 471 32. Chapter 23. Molecular cardiopharmacology and therapeutics-II - p. 487 33. Chapter 24. Molecular endocrine pharmacology and therapeutics - p. 503 34. Chapter 25. Molecular viral infections and antiviral therapeutics - p. 515 35. Index - p. 541
