Biochemical Engineering and Biotechnology, Third Edition, continues to outline the principles of biochemical processes and explain their use in the manufacturing of everyday products. The author uses a direct approach that proved to be very useful for graduate students and fellow research scientists in following the concepts of biochemical engineering and practical applications related to the field of biotechnology.
This book is unique in having many solved problems, case studies, examples, and demonstrations of detailed experiments, with simple design equations and required calculations. All chapters are fully revised and updated and include the latest research results in the field of biochemical engineering and biotechnology. The new edition emphasizes practical aspects, microorganisms, and upgrades of new types of membrane bioreactors, and it contains more case studies and solved problems, along with seven new chapters on recent topics in biosensors, bioanode, nanoscience, hydrogel, conceptual investigations on biological processes for industrial wastewater treatment, and algal growth.
Biochemical Engineering and Biotechnology, Third Edition, remains an indispensable reference for researchers in bioprocess engineering, chemical and physical biological treatment of industrial wastewater, enzyme technology, fermentation processes, nanoparticle synthesis for antibiotic loading, medicine, and drug delivery.
1. Subchapter 3.1. Introduction - p. 63 2. 3.2 Aeration and agitation - p. 65 3. 3.3 Air sparger - p. 68 4. 3.4 Agitation and mixing phenomena - p. 69 5. 3.5 Types of agitator - p. 69 6. 3.6 Oxygen transfer rate in a fermenter - p. 70 7. 3.7 Mass transfer in a gas–liquid system - p. 72 8. 3.8 Gas hold-up - p. 75 9. 3.9 Mass transfer coefficients for stirred tanks - p. 76 10. 3.10 Agitated system and mixing phenomena - p. 77 11. 3.11 Mass transfer limited process - p. 78 12. Nomenclature - p. 88 13. Greek symbols - p. 89 14. Subchapter 3.13. Case study: oxygen transfer rate model in an aerated tank for pharmaceutical wastewater - p. 89 15. Subchapter 3.14. Case study: fuel and chemical production from the water gas shift reaction by fermentation processes - p. 96 16. Chapter 4. Fermentation process control - p. 117 17. Chapter 5. Growth kinetics - p. 143 18. Abstract - p. 143 19. Outline - p. 143 20. SubChapter 5.1. Introduction - p. 143 21. 5.2 Indirect measurements of cell growth - p. 142 22. 5.3 Cell growth in batch culture - p. 145 23. 5.4 Growth phases - p. 146 24. 5.5 Kinetics of batch culture - p. 146 25. 5.6 Growth kinetics for continuous culture - p. 147 26. 5.7 Material balance for continuous stirred tank reactor - p. 152 27. 5.8 Enzyme reaction kinetics - p. 159 28. 5.9 Unstructured kinetic model - p. 186 29. Nomenclature - p. 193 30. SubChapter 5.11. Case study: enzyme kinetic models for resolution of racemic ibuprofen esters in a membrane reactor - p. 193 31. Chapter 6. Bioreactor design - p. 207 32. Abstract - p. 207 33. Outline - p. 207 34. 6.1 Introduction - p. 207 35. 6.2 Bioreactors background - p. 209 36. 6.3 Type of bioreactor - p. 209 37. 6.4 Stirred tank bioreactor - p. 212 38. 6.5 Bubble column fermenter - p. 214 39. 6.6 Airlift bioreactors - p. 216 40. 6.7 Heat transfer - p. 217 41. 6.8 Design equations for CSTR fermenter - p. 219 42. 6.9 Temperature effect on rate constant - p. 223 43. 6.10 Scale-up of stirred-tank bioreactor - p. 224 44. 6.11 Biological transport of oxygen through cells - p. 231 45. Nomenclature - p. 237 46. References - p. 240 47. Chapter 7. Downstream processing - p. 241 48. Chapter 8. Immobilization of microbial cells for the production of organic acid and ethanol - p. 277 49. Chapter 9. Material and elemental balance - p. 311 50. Abstract - p. 311 51. Outline - p. 311 52. 9.1 Introduction - p. 311 53. 9.2 Media Preparation for Fermentation - p. 312 54. 9.3 Growth of stoichiometry and elemental balances - p. 323 55. 9.4 Energy balance for continuous ethanol fermentation - p. 325 56. 9.5 Mass balance for biological processes - p. 326 57. 9.6 Conservation of mass principle - p. 328 58. 9.7 Embden–Meyerhof–Parnas pathway - p. 337 59. 9.8 Problem - p. 346 60. References - p. 347 61. Chapter 10. Application of fermentation processes - p. 350 62. Chapter 11. Production of antibiotics - p. 367 63. Chapter 12. Production of citric acid - p. 385 64. Chapter 13. Bioprocess scale-up - p. 397 65. Abstract - p. 397 66. Outline - p. 397 67. 13.1 Introduction - p. 397 68. 13.2 Scale-up procedure from laboratory scale to commercial scale - p. 398 69. 13.3 Bioreactor design criteria - p. 405 70. 13.4 CSTR chemostat versus tubular plug flow - p. 409 71. 13.5 Dynamic model and oxygen transfer rate in activated sludge - p. 420 72. 13.6 Aerobic wastewater treatment - p. 431 73. Nomenclature - p. 436 74. References - p. 436 75. Chapter 14. Single-cell protein - p. 440 76. Chapter 15. Sterilization - p. 459 77. Chapter 16. Membrane reactor - p. 481 78. Chapter 17. Advanced downstream processing in biotechnology - p. 522 79. Chapter 18. Biofuel production - p. 553 80. Chapter 19. Microbial Fuel Cell New Source of Power - p. 591 81. Chapter 20. Biological treatment - p. 624 82. Chapter 21. Toward sustainable practices in anaerobic wastewater treatment - p. 663 83. Chapter 22. Mechanisms of Biological Nutrients Removal - p. 697 84. Abstract - p. 697 85. Outline - p. 697 86. 22.1 Biological phosphorous removal - p. 697 87. 22.2 Biological nitrogen removal - p. 707 88. 22.3 Conclusions and perspectives - p. 742 89. Acknowledgement - p. 742 90. References - p. 742 91. Chapter 23. Microalgae biotechnological potentials - p. 757 92. Abstract - p. 757 93. Outline - p. 757 94. 23.1 Introduction - p. 757 95. 23.2 Metabolic analysis of microalgae - p. 760 96. 23.3 Microalgae cultivation - p. 772 97. 23.4 Microalgal growth kinetics - p. 776 98. 23.5 Biotechnological applications of algae - p. 782 99. References - p. 793 100. Chapter 24. Application of bioanodes in microbial fuel cells - p. 805 101. Chapter 25. Biosensors developments: fundamentals and applications - p. 827 102. Chapter 26. Biomaterial-based hydrogels for bacterial infection treatment - p. 863 103. Chapter 27. Bacterial exopolysaccharides production and applications - p. 882 104. Appendix - p. 905 105. Index - p. 907
Biochemical Engineering and Biotechnology, Third Edition, continues to outline the principles of biochemical processes and explain their use in the manufacturing of everyday products. The author uses a direct approach that proved to be very useful for graduate students and fellow research scientists in following the concepts of biochemical engineering and practical applications related to the field of biotechnology.
This book is unique in having many solved problems, case studies, examples, and demonstrations of detailed experiments, with simple design equations and required calculations. All chapters are fully revised and updated and include the latest research results in the field of biochemical engineering and biotechnology. The new edition emphasizes practical aspects, microorganisms, and upgrades of new types of membrane bioreactors, and it contains more case studies and solved problems, along with seven new chapters on recent topics in biosensors, bioanode, nanoscience, hydrogel, conceptual investigations on biological processes for industrial wastewater treatment, and algal growth.
Biochemical Engineering and Biotechnology, Third Edition, remains an indispensable reference for researchers in bioprocess engineering, chemical and physical biological treatment of industrial wastewater, enzyme technology, fermentation processes, nanoparticle synthesis for antibiotic loading, medicine, and drug delivery.
1. Subchapter 3.1. Introduction - p. 63 2. 3.2 Aeration and agitation - p. 65 3. 3.3 Air sparger - p. 68 4. 3.4 Agitation and mixing phenomena - p. 69 5. 3.5 Types of agitator - p. 69 6. 3.6 Oxygen transfer rate in a fermenter - p. 70 7. 3.7 Mass transfer in a gas–liquid system - p. 72 8. 3.8 Gas hold-up - p. 75 9. 3.9 Mass transfer coefficients for stirred tanks - p. 76 10. 3.10 Agitated system and mixing phenomena - p. 77 11. 3.11 Mass transfer limited process - p. 78 12. Nomenclature - p. 88 13. Greek symbols - p. 89 14. Subchapter 3.13. Case study: oxygen transfer rate model in an aerated tank for pharmaceutical wastewater - p. 89 15. Subchapter 3.14. Case study: fuel and chemical production from the water gas shift reaction by fermentation processes - p. 96 16. Chapter 4. Fermentation process control - p. 117 17. Chapter 5. Growth kinetics - p. 143 18. Abstract - p. 143 19. Outline - p. 143 20. SubChapter 5.1. Introduction - p. 143 21. 5.2 Indirect measurements of cell growth - p. 142 22. 5.3 Cell growth in batch culture - p. 145 23. 5.4 Growth phases - p. 146 24. 5.5 Kinetics of batch culture - p. 146 25. 5.6 Growth kinetics for continuous culture - p. 147 26. 5.7 Material balance for continuous stirred tank reactor - p. 152 27. 5.8 Enzyme reaction kinetics - p. 159 28. 5.9 Unstructured kinetic model - p. 186 29. Nomenclature - p. 193 30. SubChapter 5.11. Case study: enzyme kinetic models for resolution of racemic ibuprofen esters in a membrane reactor - p. 193 31. Chapter 6. Bioreactor design - p. 207 32. Abstract - p. 207 33. Outline - p. 207 34. 6.1 Introduction - p. 207 35. 6.2 Bioreactors background - p. 209 36. 6.3 Type of bioreactor - p. 209 37. 6.4 Stirred tank bioreactor - p. 212 38. 6.5 Bubble column fermenter - p. 214 39. 6.6 Airlift bioreactors - p. 216 40. 6.7 Heat transfer - p. 217 41. 6.8 Design equations for CSTR fermenter - p. 219 42. 6.9 Temperature effect on rate constant - p. 223 43. 6.10 Scale-up of stirred-tank bioreactor - p. 224 44. 6.11 Biological transport of oxygen through cells - p. 231 45. Nomenclature - p. 237 46. References - p. 240 47. Chapter 7. Downstream processing - p. 241 48. Chapter 8. Immobilization of microbial cells for the production of organic acid and ethanol - p. 277 49. Chapter 9. Material and elemental balance - p. 311 50. Abstract - p. 311 51. Outline - p. 311 52. 9.1 Introduction - p. 311 53. 9.2 Media Preparation for Fermentation - p. 312 54. 9.3 Growth of stoichiometry and elemental balances - p. 323 55. 9.4 Energy balance for continuous ethanol fermentation - p. 325 56. 9.5 Mass balance for biological processes - p. 326 57. 9.6 Conservation of mass principle - p. 328 58. 9.7 Embden–Meyerhof–Parnas pathway - p. 337 59. 9.8 Problem - p. 346 60. References - p. 347 61. Chapter 10. Application of fermentation processes - p. 350 62. Chapter 11. Production of antibiotics - p. 367 63. Chapter 12. Production of citric acid - p. 385 64. Chapter 13. Bioprocess scale-up - p. 397 65. Abstract - p. 397 66. Outline - p. 397 67. 13.1 Introduction - p. 397 68. 13.2 Scale-up procedure from laboratory scale to commercial scale - p. 398 69. 13.3 Bioreactor design criteria - p. 405 70. 13.4 CSTR chemostat versus tubular plug flow - p. 409 71. 13.5 Dynamic model and oxygen transfer rate in activated sludge - p. 420 72. 13.6 Aerobic wastewater treatment - p. 431 73. Nomenclature - p. 436 74. References - p. 436 75. Chapter 14. Single-cell protein - p. 440 76. Chapter 15. Sterilization - p. 459 77. Chapter 16. Membrane reactor - p. 481 78. Chapter 17. Advanced downstream processing in biotechnology - p. 522 79. Chapter 18. Biofuel production - p. 553 80. Chapter 19. Microbial Fuel Cell New Source of Power - p. 591 81. Chapter 20. Biological treatment - p. 624 82. Chapter 21. Toward sustainable practices in anaerobic wastewater treatment - p. 663 83. Chapter 22. Mechanisms of Biological Nutrients Removal - p. 697 84. Abstract - p. 697 85. Outline - p. 697 86. 22.1 Biological phosphorous removal - p. 697 87. 22.2 Biological nitrogen removal - p. 707 88. 22.3 Conclusions and perspectives - p. 742 89. Acknowledgement - p. 742 90. References - p. 742 91. Chapter 23. Microalgae biotechnological potentials - p. 757 92. Abstract - p. 757 93. Outline - p. 757 94. 23.1 Introduction - p. 757 95. 23.2 Metabolic analysis of microalgae - p. 760 96. 23.3 Microalgae cultivation - p. 772 97. 23.4 Microalgal growth kinetics - p. 776 98. 23.5 Biotechnological applications of algae - p. 782 99. References - p. 793 100. Chapter 24. Application of bioanodes in microbial fuel cells - p. 805 101. Chapter 25. Biosensors developments: fundamentals and applications - p. 827 102. Chapter 26. Biomaterial-based hydrogels for bacterial infection treatment - p. 863 103. Chapter 27. Bacterial exopolysaccharides production and applications - p. 882 104. Appendix - p. 905 105. Index - p. 907
