Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease.
This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens.
1. Biochemistry of Collagens, Laminins and Elastin - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of contributors - p. xv 7. Foreword - p. xix 8. Preface - p. xxi 9. Acknowledgments - p. xxiii 10. List of abbreviations - p. xxv 11. Chapter 1 Type I collagen - p. 1 12. References - p. 7 13. Chapter 2 Type II collagen - p. 13 14. Chapter 3 Type III collagen - p. 23 15. Chapter 4 Type IV collagen - p. 37 16. Chapter 5 Type V collagen - p. 55 17. Chapter 6 Type VI collagen - p. 61 18. Chapter 7 Type VII collagen - p. 75 19. Chapter 8 Type VIII collagen - p. 81 20. Chapter 9 Type IX collagen - p. 89 21. Chapter 10 Type X collagen - p. 97 22. Chapter 11 Type XI collagen - p. 105 23. Chapter 12 Type XII collagen - p. 113 24. References - p. 118 25. Chapter 13 Type XIII collagen - p. 123 26. Chapter 14 Type XIV collagen - p. 131 27. References - p. 134 28. Chapter 15 Type XV collagen - p. 137 29. References - p. 140 30. Chapter 16 Type XVI collagen - p. 145 31. Chapter 17 Type XVII collagen - p. 153 32. References - p. 157 33. Chapter 18 Type XVIII collagen - p. 161 34. Chapter 19 Type XIX collagen - p. 175 35. Chapter 20 Type XX collagen - p. 181 36. References - p. 184 37. Chapter 21 Type XXI collagen - p. 187 38. References - p. 190 39. Chapter 22 Type XXII collagen - p. 193 40. Chapter 23 Type XXIII collagen - p. 199 41. Chapter 24 Type XXIV collagen - p. 203 42. References - p. 205 43. Chapter 25 Type XXV collagen - p. 207 44. References - p. 211 45. Chapter 26 Type XXVI collagen - p. 213 46. References - p. 215 47. Chapter 27 Type XXVII collagen - p. 217 48. References - p. 220 49. Chapter 28 Type XXVIII collagen - p. 223 50. Chapter 29 Laminins - p. 227 51. Chapter 30 Elastin - p. 279 52. Chapter 31 Fibronectin - p. 291 53. Chapter 32 The extended family of collagens - p. 303 54. Chapter 33 Collagen receptors - p. 317 55. Chapter 34 Aging—the most important collagen neoepitope? - p. 337 56. Chapter 35 Collagen chaperones - p. 351 57. Chapter 36 Collagen diseases - p. 371 58. Chapter 37 The signals of the extracellular matrix - p. 399 59. Chapter 38 The roles of collagens and fibroblasts in cancer - p. 419 60. Chapter 39 Use of extracellular matrix biomarkers in clinical research - p. 435 61. Chapter 40 Common confounders when evaluating noninvasive protein biomarkers - p. 445 62. Chapter 41 Extracellular matrix and endotypes - p. 455 63. Chapter 42 The extracellular matrix of the skin: systemic diseases with local manifestations - p. 459 64. Chapter 43 The basement membrane and its role in pulmonary disease - p. 473 65. Chapter 44 Collagen remodeling in inflammatory bowel disease - p. 483 66. Chapter 45 ECM biomarkers in population-based cohorts - p. 495 67. Chapter 46 Collagen biomarkers of chronic diseases - p. 501 68. References - p. 503 69. Index - p. 509
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease.
This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens.
1. Biochemistry of Collagens, Laminins and Elastin - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of contributors - p. xv 7. Foreword - p. xix 8. Preface - p. xxi 9. Acknowledgments - p. xxiii 10. List of abbreviations - p. xxv 11. Chapter 1 Type I collagen - p. 1 12. References - p. 7 13. Chapter 2 Type II collagen - p. 13 14. Chapter 3 Type III collagen - p. 23 15. Chapter 4 Type IV collagen - p. 37 16. Chapter 5 Type V collagen - p. 55 17. Chapter 6 Type VI collagen - p. 61 18. Chapter 7 Type VII collagen - p. 75 19. Chapter 8 Type VIII collagen - p. 81 20. Chapter 9 Type IX collagen - p. 89 21. Chapter 10 Type X collagen - p. 97 22. Chapter 11 Type XI collagen - p. 105 23. Chapter 12 Type XII collagen - p. 113 24. References - p. 118 25. Chapter 13 Type XIII collagen - p. 123 26. Chapter 14 Type XIV collagen - p. 131 27. References - p. 134 28. Chapter 15 Type XV collagen - p. 137 29. References - p. 140 30. Chapter 16 Type XVI collagen - p. 145 31. Chapter 17 Type XVII collagen - p. 153 32. References - p. 157 33. Chapter 18 Type XVIII collagen - p. 161 34. Chapter 19 Type XIX collagen - p. 175 35. Chapter 20 Type XX collagen - p. 181 36. References - p. 184 37. Chapter 21 Type XXI collagen - p. 187 38. References - p. 190 39. Chapter 22 Type XXII collagen - p. 193 40. Chapter 23 Type XXIII collagen - p. 199 41. Chapter 24 Type XXIV collagen - p. 203 42. References - p. 205 43. Chapter 25 Type XXV collagen - p. 207 44. References - p. 211 45. Chapter 26 Type XXVI collagen - p. 213 46. References - p. 215 47. Chapter 27 Type XXVII collagen - p. 217 48. References - p. 220 49. Chapter 28 Type XXVIII collagen - p. 223 50. Chapter 29 Laminins - p. 227 51. Chapter 30 Elastin - p. 279 52. Chapter 31 Fibronectin - p. 291 53. Chapter 32 The extended family of collagens - p. 303 54. Chapter 33 Collagen receptors - p. 317 55. Chapter 34 Aging—the most important collagen neoepitope? - p. 337 56. Chapter 35 Collagen chaperones - p. 351 57. Chapter 36 Collagen diseases - p. 371 58. Chapter 37 The signals of the extracellular matrix - p. 399 59. Chapter 38 The roles of collagens and fibroblasts in cancer - p. 419 60. Chapter 39 Use of extracellular matrix biomarkers in clinical research - p. 435 61. Chapter 40 Common confounders when evaluating noninvasive protein biomarkers - p. 445 62. Chapter 41 Extracellular matrix and endotypes - p. 455 63. Chapter 42 The extracellular matrix of the skin: systemic diseases with local manifestations - p. 459 64. Chapter 43 The basement membrane and its role in pulmonary disease - p. 473 65. Chapter 44 Collagen remodeling in inflammatory bowel disease - p. 483 66. Chapter 45 ECM biomarkers in population-based cohorts - p. 495 67. Chapter 46 Collagen biomarkers of chronic diseases - p. 501 68. References - p. 503 69. Index - p. 509
