Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences.
As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.
1. Biochemistry of Lipids, Lipoproteins and Membranes - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xxiii 7. Preface - p. xxvii 8. Chapter 1 Functional roles of lipids in biological membranes - p. 1 9. Chapter 2 Methods of lipid analysis - p. 53 10. Chapter 3 Fatty acid and phospholipid biosynthesis in prokaryotes - p. 85 11. Chapter 4 Lipid metabolism in plants - p. 121 12. Chapter 5 Fatty acid handling in mammalian cells - p. 161 13. Chapter 6 Fatty acid desaturation and elongation in mammals - p. 201 14. Chapter 7 Phospholipid synthesis in mammalian cells - p. 227 15. Chapter 8 Phospholipid catabolism - p. 259 16. Chapter 9 Sphingolipids - p. 281 17. Chapter 10 Cholesterol synthesis - p. 317 18. Chapter 11 Structure and function of lipid droplets - p. 357 19. Chapter 12 Bile acid metabolism - p. 395 20. Chapter 13 Lipid modification of proteins - p. 429 21. Chapter 14 Inter- and intra-membrane lipid transport - p. 457 22. Chapter 15 High-density lipoproteins - p. 487 23. Chapter 16 Assembly and secretion of triacylglycerol-rich lipoproteins - p. 515 24. Chapter 17 Lipoprotein(a) - p. 547 25. Chapter 18 Lipoprotein receptors - p. 583 26. Chapter 19 Atherosclerosis - p. 623 27. Chapter 20 Diabetic dyslipidaemia - p. 667 28. Index - p. 695
Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences.
As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis.
1. Biochemistry of Lipids, Lipoproteins and Membranes - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xxiii 7. Preface - p. xxvii 8. Chapter 1 Functional roles of lipids in biological membranes - p. 1 9. Chapter 2 Methods of lipid analysis - p. 53 10. Chapter 3 Fatty acid and phospholipid biosynthesis in prokaryotes - p. 85 11. Chapter 4 Lipid metabolism in plants - p. 121 12. Chapter 5 Fatty acid handling in mammalian cells - p. 161 13. Chapter 6 Fatty acid desaturation and elongation in mammals - p. 201 14. Chapter 7 Phospholipid synthesis in mammalian cells - p. 227 15. Chapter 8 Phospholipid catabolism - p. 259 16. Chapter 9 Sphingolipids - p. 281 17. Chapter 10 Cholesterol synthesis - p. 317 18. Chapter 11 Structure and function of lipid droplets - p. 357 19. Chapter 12 Bile acid metabolism - p. 395 20. Chapter 13 Lipid modification of proteins - p. 429 21. Chapter 14 Inter- and intra-membrane lipid transport - p. 457 22. Chapter 15 High-density lipoproteins - p. 487 23. Chapter 16 Assembly and secretion of triacylglycerol-rich lipoproteins - p. 515 24. Chapter 17 Lipoprotein(a) - p. 547 25. Chapter 18 Lipoprotein receptors - p. 583 26. Chapter 19 Atherosclerosis - p. 623 27. Chapter 20 Diabetic dyslipidaemia - p. 667 28. Index - p. 695
