Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance.
Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges.
1. Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table Of Contents - p. iv 6. Cover Image Insert - p. v 7. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. vii 8. About the Series Editor - p. ix 9. Aims and Scope of Volume - p. xi 10. About the Volume Editors - p. xiii 11. Preface - p. xv 12. Contributors - p. xxvii 13. Chapter 1 Luminal A breast cancer resistance mechanisms and emerging treatments - p. 1 14. Chapter 2 Development of novel androgen receptor inhibitors to overcome castrate-resistant prostate cancer - p. 23 15. Chapter 3 Autotaxin is an important component of the tumor microenvironment and a major modulator of therapy responses for breast cancer - p. 47 16. Chapter 4 Revisiting immunogenic cell death to improve treatment response in cancer - p. 65 17. Chapter 5 Overcoming therapeutic resistance in glioblastoma: Moving beyond the sole targeting of the glioma cells - p. 91 18. Chapter 6 Preventing phenotypic plasticity in cancer to mitigate therapy resistance - p. 119 19. Chapter 7 Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia (T-ALL) - p. 161 20. Chapter 8 Tumor metabolic reprogramming in therapeutic resistance - p. 199 21. Chapter 9 From genetic data and structures to drug development: New approaches to target Eph receptors - p. 227 22. Chapter 10 Anastasis, recovery from the brink of death as a mechanism of drug resistance - p. 251 23. Chapter 11 Overcoming drug resistance in osteosarcoma and pancreatic adenocarcinoma with radioimmunotherapy - p. 261 24. Index - p. 273
Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance.
Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges.
1. Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table Of Contents - p. iv 6. Cover Image Insert - p. v 7. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. vii 8. About the Series Editor - p. ix 9. Aims and Scope of Volume - p. xi 10. About the Volume Editors - p. xiii 11. Preface - p. xv 12. Contributors - p. xxvii 13. Chapter 1 Luminal A breast cancer resistance mechanisms and emerging treatments - p. 1 14. Chapter 2 Development of novel androgen receptor inhibitors to overcome castrate-resistant prostate cancer - p. 23 15. Chapter 3 Autotaxin is an important component of the tumor microenvironment and a major modulator of therapy responses for breast cancer - p. 47 16. Chapter 4 Revisiting immunogenic cell death to improve treatment response in cancer - p. 65 17. Chapter 5 Overcoming therapeutic resistance in glioblastoma: Moving beyond the sole targeting of the glioma cells - p. 91 18. Chapter 6 Preventing phenotypic plasticity in cancer to mitigate therapy resistance - p. 119 19. Chapter 7 Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia (T-ALL) - p. 161 20. Chapter 8 Tumor metabolic reprogramming in therapeutic resistance - p. 199 21. Chapter 9 From genetic data and structures to drug development: New approaches to target Eph receptors - p. 227 22. Chapter 10 Anastasis, recovery from the brink of death as a mechanism of drug resistance - p. 251 23. Chapter 11 Overcoming drug resistance in osteosarcoma and pancreatic adenocarcinoma with radioimmunotherapy - p. 261 24. Index - p. 273
