Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions.
The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.
A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Foreword - p. xv 7. Part I. Biology of Stem Cell Niches and Molecular Mechanisms - p. xv 8. Chapter 1. The Need to Study, Mimic, and Target Stem Cell Niches - p. 3 9. Chapter 2. Harnessing the Biology of Stem Cells' Niche - p. 15 10. Chapter 3. Pluripotent Stem Cell Microenvironment - p. 33 11. Chapter 4. Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling - p. 51 12. Chapter 5. HSC Niche: Regulation of Mobilization and Homing - p. 63 13. Chapter 6. Neuronal Stem Cell Niches of the Brain - p. 75 14. Chapter 7. Cardiovascular Stem Cell Niche - p. 93 15. Chapter 8. Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids - p. 111 16. Chapter 9. The Epithelial Stem Cell Niche in Skin - p. 127 17. Chapter 10. The Satellite Cell Niche in Skeletal Muscle - p. 145 18. Chapter 11. The Cancer Stem Cell Niche - p. 167 19. Chapter 12. Cellular Senescence and Stem Cell Niche - p. 185 20. Part II. Biochemical and Physical Cues in The Stem Cell Niche Directing Cell Fate - p. 192 21. Chapter 13. Matrix Chemistry Controlling Stem Cell Behavior - p. 195 22. Chapter 14. Matrix Growth Factor and Surface Ligand Presentation - p. 215 23. Chapter 15. Effect of Matrix Mechanical Forces and Geometry on Stem Cell Behavior - p. 233 24. Chapter 16. Wettability Effect on Stem Cell Behavior - p. 245 25. Chapter 17. Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways - p. 257 26. Chapter 18. Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and Applications - p. 273 27. Part III. Designing Smart Biomaterials to Mimic and Control Stem Cell Niche - p. 291 28. Chapter 19. Polymer Design and Development - p. 295 29. Chapter 20. Design and Development of Ceramics and Glasses - p. 315 30. Chapter 21. Surface Functionalization of Biomaterials - p. 331 31. Chapter 22. Biofunctional Hydrogels for Three-Dimensional Stem Cell Culture - p. 345 32. Chapter 23. Technologies to Engineer Cell Substrate Mechanics in Hydrogels - p. 363 33. Chapter 24. Micro- and Nanosurface Patterning Technologies - p. 375 34. Chapter 25. Self-Assembled Nanostructures (SANs) - p. 391 35. Chapter 26. Biomimetic Nanofibers as Artificial Stem Cell Niche - p. 411 36. Chapter 27. Employing Microfluidic Devices to Induce Concentration Gradients - p. 429 37. Part IV. Bioengineering Strategies to Model Synthetic Stem Cell Niches - p. 442 38. Chapter 28. Engineering Niches for Embryonic and Induced Pluripotent Stem Cells - p. 445 39. Chapter 29. Engineering Niches for Cardiovascular Tissue Regeneration - p. 459 40. Chapter 30. Engineering Niches for Blood Vessel Regeneration - p. 479 41. Chapter 31. Engineering Niches for Bone Tissue Regeneration - p. 499 42. Chapter 32. Engineering Vascular Niche for Bone Tissue Regeneration - p. 517 43. Chapter 33. Engineering Niches for Cartilage Tissue Regeneration - p. 531 44. Chapter 34. Engineering Niches for Stem and Progenitor Cell Differentiation Into Immune Cells - p. 547 45. Chapter 35. Engineering Niches for Skin and Wound Healing - p. 559 46. Chapter 36. Designing Stem Cell Niche for Liver Development and Regeneration - p. 581 47. Chapter 37. Engineering the Niche for Intestinal Regeneration - p. 601 48. Index - p. 617
Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions.
The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.
A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Foreword - p. xv 7. Part I. Biology of Stem Cell Niches and Molecular Mechanisms - p. xv 8. Chapter 1. The Need to Study, Mimic, and Target Stem Cell Niches - p. 3 9. Chapter 2. Harnessing the Biology of Stem Cells' Niche - p. 15 10. Chapter 3. Pluripotent Stem Cell Microenvironment - p. 33 11. Chapter 4. Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling - p. 51 12. Chapter 5. HSC Niche: Regulation of Mobilization and Homing - p. 63 13. Chapter 6. Neuronal Stem Cell Niches of the Brain - p. 75 14. Chapter 7. Cardiovascular Stem Cell Niche - p. 93 15. Chapter 8. Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids - p. 111 16. Chapter 9. The Epithelial Stem Cell Niche in Skin - p. 127 17. Chapter 10. The Satellite Cell Niche in Skeletal Muscle - p. 145 18. Chapter 11. The Cancer Stem Cell Niche - p. 167 19. Chapter 12. Cellular Senescence and Stem Cell Niche - p. 185 20. Part II. Biochemical and Physical Cues in The Stem Cell Niche Directing Cell Fate - p. 192 21. Chapter 13. Matrix Chemistry Controlling Stem Cell Behavior - p. 195 22. Chapter 14. Matrix Growth Factor and Surface Ligand Presentation - p. 215 23. Chapter 15. Effect of Matrix Mechanical Forces and Geometry on Stem Cell Behavior - p. 233 24. Chapter 16. Wettability Effect on Stem Cell Behavior - p. 245 25. Chapter 17. Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways - p. 257 26. Chapter 18. Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and Applications - p. 273 27. Part III. Designing Smart Biomaterials to Mimic and Control Stem Cell Niche - p. 291 28. Chapter 19. Polymer Design and Development - p. 295 29. Chapter 20. Design and Development of Ceramics and Glasses - p. 315 30. Chapter 21. Surface Functionalization of Biomaterials - p. 331 31. Chapter 22. Biofunctional Hydrogels for Three-Dimensional Stem Cell Culture - p. 345 32. Chapter 23. Technologies to Engineer Cell Substrate Mechanics in Hydrogels - p. 363 33. Chapter 24. Micro- and Nanosurface Patterning Technologies - p. 375 34. Chapter 25. Self-Assembled Nanostructures (SANs) - p. 391 35. Chapter 26. Biomimetic Nanofibers as Artificial Stem Cell Niche - p. 411 36. Chapter 27. Employing Microfluidic Devices to Induce Concentration Gradients - p. 429 37. Part IV. Bioengineering Strategies to Model Synthetic Stem Cell Niches - p. 442 38. Chapter 28. Engineering Niches for Embryonic and Induced Pluripotent Stem Cells - p. 445 39. Chapter 29. Engineering Niches for Cardiovascular Tissue Regeneration - p. 459 40. Chapter 30. Engineering Niches for Blood Vessel Regeneration - p. 479 41. Chapter 31. Engineering Niches for Bone Tissue Regeneration - p. 499 42. Chapter 32. Engineering Vascular Niche for Bone Tissue Regeneration - p. 517 43. Chapter 33. Engineering Niches for Cartilage Tissue Regeneration - p. 531 44. Chapter 34. Engineering Niches for Stem and Progenitor Cell Differentiation Into Immune Cells - p. 547 45. Chapter 35. Engineering Niches for Skin and Wound Healing - p. 559 46. Chapter 36. Designing Stem Cell Niche for Liver Development and Regeneration - p. 581 47. Chapter 37. Engineering the Niche for Intestinal Regeneration - p. 601 48. Index - p. 617
