Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xiii 7. Chapter One: The endless frontier of tRNA synthetases - p. page_1 8. Chapter Two: The evolution of aminoacyl-tRNA synthetases: From dawn to LUCA - p. page_11 9. Chapter Three: Putting amino acids onto tRNAs: The aminoacyl-tRNA synthetases as catalysts - p. page_39 10. Chapter Four: Trans-editing by aminoacyl-tRNA synthetase-like editing domains - p. page_69 11. Chapter Five: Noncanonical inputs and outputs of tRNA aminoacylation - p. page_117 12. Chapter Six: Structures and functions of multi-tRNA synthetase complexes - p. page_149 13. Chapter Seven: Mitochondrial aminoacyl-tRNA synthetases - p. page_175 14. Chapter Eight: Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases - p. page_207 15. Chapter Nine: Aminoacyl-tRNA synthetases in cell signaling - p. page_243 16. Chapter Ten: Human diseases linked to cytoplasmic aminoacyl-tRNA synthetases - p. page_277 17. Chapter Eleven: Aminoacyl-tRNA synthetases as drug targets - p. page_321 18. Chapter Twelve: Engineering aminoacyl-tRNA synthetases for use in synthetic biology - p. page_351 19. Chapter Thirteen: Novel functions of cytoplasmic aminoacyl-tRNA synthetases shaping the hallmarks of cancer - p. page_397
Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xiii 7. Chapter One: The endless frontier of tRNA synthetases - p. page_1 8. Chapter Two: The evolution of aminoacyl-tRNA synthetases: From dawn to LUCA - p. page_11 9. Chapter Three: Putting amino acids onto tRNAs: The aminoacyl-tRNA synthetases as catalysts - p. page_39 10. Chapter Four: Trans-editing by aminoacyl-tRNA synthetase-like editing domains - p. page_69 11. Chapter Five: Noncanonical inputs and outputs of tRNA aminoacylation - p. page_117 12. Chapter Six: Structures and functions of multi-tRNA synthetase complexes - p. page_149 13. Chapter Seven: Mitochondrial aminoacyl-tRNA synthetases - p. page_175 14. Chapter Eight: Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases - p. page_207 15. Chapter Nine: Aminoacyl-tRNA synthetases in cell signaling - p. page_243 16. Chapter Ten: Human diseases linked to cytoplasmic aminoacyl-tRNA synthetases - p. page_277 17. Chapter Eleven: Aminoacyl-tRNA synthetases as drug targets - p. page_321 18. Chapter Twelve: Engineering aminoacyl-tRNA synthetases for use in synthetic biology - p. page_351 19. Chapter Thirteen: Novel functions of cytoplasmic aminoacyl-tRNA synthetases shaping the hallmarks of cancer - p. page_397
